 | Eric Bana als Henry DeTamble |
 | Rachel McAdams als Clare Abshire |
 | Michelle Nolden als Annette DeTamble |
 | Arliss Howard als Richard DeTamble |
 | Ron Livingston als Gomez |
 | Stephen Tobolowsky als Dr. Kendrick |
 | Brian Bisson als Mark Abshire |
 | Maggie Castle als Alicia Abshire |
 | Brooklynn Proulx als Clare at Six and Eight |
 | James Lafazanos als Jeremy (Gallery Owner) |
 | Dan Duran als Lottery Announcer |
 | Jan Caruana als Dr. Osman's Nurse |
 | Jean Yoon als Dr. Montague |
 | Duane Murray als Resident Doctor |
 | Philip Craig als Philip Abshire |
 | Fiona Reid als Lucille Abshire |
 | Alex Ferris als Henry at Six |
 | Katherine Trowell als Hospital Receptionist |
| Bart Bedford als Library Researcher |
| Esther Jun als Waitress |
| Esther Jun als Chicago Police #1 |
| Craig Snoyer als Chicago Police #2 |
 | Carly Street als Librarian |
| Romyen Tangsubutra als Thai Waiter |
| Mario Tufino als Barber |
| Shawn Storer als Moving Man |
| David Talbot als Pastor |
| Kenner Ames als TV Sales Person |
| Alison MacLeod als Realtor |
| Hailey McCann als Alba at Nine and Ten |
 | Donald Carrier als Dr. Osman |
 | Tatum McCann als Alba at Four and Five |
 | Jon Bruno als Chicago Radio Show Host |
 | Scott Menville als Voice Over (Voice) |
| Paul Francis als Hunting Buddy |
 | Matt Birman als Chicago Police #1 |
| Kristin Hahn | Producer |
| Sara Moe | Producer |
| Jennifer L. Smith | Casting |
| Justis Greene | Executive Producer |
| Michele Weiss | Executive Producer |
| Deborah Aquila | Casting |
| Robert Schwentke | Director |
| Dede Gardner | Producer |
| Nick Wechsler | Producer |
| Brad Pitt | Executive Producer |
| Thom Noble | Editor |
| Robin D. Cook | Casting |
| Tricia Wood | Casting |
| Mychael Danna | Original Music Composer |
| Patricia Cuccia | Set Decoration |
| Richard Brener | Executive Producer |
| Peter Grundy | Art Direction |
| Bruce Joel Rubin | Screenplay |
| Audrey Niffenegger | Novel |
| Florian Ballhaus | Director of Photography |
| Jon Hutman | Production Design |
| Kathleen Meade | Costume Supervisor |
| Ann Brodie | Makeup Department Head |
| Julie Weiss | Costume Design |
| James Moriana | Foley |
| Susan Exton-Stranks | Key Hair Stylist |
| Andy Day | Gaffer |
| Charlie Grubbs | Rigging Gaffer |
| Craig Mann | Sound Re-Recording Mixer |
| Terence J. Cox | Pyrotechnician |
| Dorota Zajac | Key Makeup Artist |
| Mongo Andrews | Rigging Grip |
| Jeffrey Wilhoit | Foley |
| Hector C. Gika | Sound Designer |
| Michelle Pazer | ADR Editor |
| Dave McMoyler | Supervising Sound Editor |
| Erika A. McKee | Visual Effects Producer |
| Francesca Paris | Hairstylist |
| Philip Esteves | Rigging Gaffer |
| Alan Markfield | Still Photographer |
| Andy Wilkoff | CG Supervisor |
| Stella Cottini | Key Costumer |
| Aaron Marshall | First Assistant Editor |
| John Vrakking | Rigging Grip |
| Steve La Fayette | Boom Operator |
| Bob Bowen | Music Supervisor |
| Diane Woodhouse | Special Effects Coordinator |
| Vincent Sullivan | Hair Department Head |
| Richard Emerson | Key Grip |
| Lisa Zagoria | Casting Assistant |
| Elizabeth Tremblay | Script Supervisor |
| Gordon Chacra | Boom Operator |
| Steve Robinson | Foley |
| Michael Minkler | Sound Re-Recording Mixer |
| Thomas Lappin | Camera Operator |
| Candide Franklyn | Steadicam Operator |
| Samantha Finkler | Casting Associate |
| Laura Kaminski | Set Costumer |
| Robert E. Phillips | Digital Intermediate |
| Tim Walston | Sound Effects Editor |
| David Jones | Visual Effects Supervisor |
| Erin Toner | Casting Associate |
| Bronwyn Waddington | Visual Effects Editor |
| Michael Hall | Camera Operator |
| Karen Vassar Triest | Sound Effects Editor |
| Beth Dewey | Digital Intermediate |
| Amy Wright | Choreographer |
| Richard Ford | Music Editor |
| Alex Burdett | Special Effects Supervisor |
| Michal Bigger | Makeup Artist |
| Jamie Frith | Art Department Coordinator |
| Kimaree Long | ADR Editor |
| David Allan | Lighting Technician |
| Laurel Bresnahan | Studio Teachers |
| Terri Douglas | ADR Voice Casting |
| John MacNeil | Set Designer |
| Jerry Borris | Best Boy Electrician |
| Mongo Andrews | Key Rigging Grip |
| Paul Krysinski | Special Effects Technician |
| Sean Marjoram | Electrician |
| Donna McLain | Electrician |
| Dean Stinchcombe | First Assistant Camera |
| Laura MacCon | Makeup Artist |
| Jaclyn Shoub | Concept Artist |
| Helen Marchfield | Makeup Artist |
| Kirk Cheney | Construction Coordinator |
| Jason Graham | First Assistant Art Direction |
| Kenny Meinzinger | Set Dresser |
| Darlene R. Hunt | Extras Casting |
| Constance Buck | Wardrobe Supervisor |
| Pamela Milone-McLaughlin | Hairstylist |
| Danielle Fleury | Set Decoration Buyer |
| Ian Anderson | First Assistant "B" Camera |
| Agnes M. Gibicar | Hairstylist |
| Kari Measham | Set Decoration Buyer |
| Jeremy Simser | Storyboard Artist |
| Keith Pokorski | First Assistant Camera |
| Robyn Rosenberg | Truck Supervisor |
| Nadia 'Sunny' Sorge | Wardrobe Assistant |
| Vivian Guzman | Hairstylist |
| Julie Ng | Epk Producer |
| Tim Mogg | Makeup Artist |
| Matt Middleton | Second Assistant Art Director |
| Russel Bowie | First Assistant "A" Camera |
| Rachel Komar | Extras Casting |
| Matthew LeCrone | Electrician |
| Elis Y. Lam | First Assistant Art Direction |
| Brodie Spaull | Special Effects Technician |
| Jason Hamer | Special Effects Technician |
| John Stoneham Jr. | Stunt Coordinator |
| Bryan J. Thomas | Stunts |
| Flint Eagle | Stunt Driver |
| Rick LeFevour | Stunt Coordinator |
| Brittney Banks | Stunts |
| Regan Moore | Stunts |
| Steve Lucescu | Stunt Driver |
| Shelley Cook | Stunts |
| Dana Howes | Transportation Coordinator |
