 | Mark Torgl als Melvin Junko |
 | Mitch Cohen als The Toxic Avenger |
| Andree Maranda als Sara |
| Pat Ryan als Mayor Peter Belgoody |
 | Cindy Manion als Julie |
 | Patrick Kilpatrick als Leroy |
| Jennifer Prichard als Wanda |
 | Robert Prichard als Slug |
| Kenneth Kessler als The Toxic Avenger (voice) |
 | Gary Schneider als Bozo |
| Dick Martinsen als Officer O'Clancy |
| Chris Liano als Walter Harris |
| Dan Snow als Cigar Face |
| Doug Isbecque als Knuckles |
| Charles Lee Jr. als Nipples |
| Larry Sulton als Frank |
 | Michael Russo als Rico |
| Norma Pratt als Mrs. Haskell |
 | Andrew Craig als Fred |
| Ryan Sexton als Johnny |
| Sarabel Levinson als Melvin's Mom |
| Al Pia als Tom Wrightson |
| Reuben Guss als Dr. Snodburger |
| Barbara Gurskey als Barbie |
 | Rick Collins als Bully |
 | Marisa Tomei als Health Club Girl (uncredited) |
 | Randy Schein als Bozo's Friend |
| John Reidy als Terrorist |
| Lenny Mandel als The Rabbi |
 | Scott Leva als Policeman (uncredited) |
| Dolly Hall als Girl in Health Club |
| Richard Duggan als Ice Cream Man |
| June De Young als Reporter |
| Donald O'Toole als Man That Hates His Mother-in-Law |
| Donna Winter als Mayor's Secretary |
| Caroline Baron | Production Manager |
| Charles Croughwell | Stunts |
| Durrell Nelson | Stunts |
| James A. Lebovitz | Director of Photography |
| Lloyd Kaufman | Director |
| Lloyd Kaufman | Director of Photography |
| Lloyd Kaufman | Producer |
| Lloyd Kaufman | Story |
| Lloyd Kaufman | Additional Writing |
| Michael Herz | Director |
| Michael Herz | Producer |
| Brian Katkin | Casting |
| Mark Torgl | Script Supervisor |
| Jim Grib | Lighting Director |
| John Elias Michalakis | Sound Editor |
| Richard W. Haines | Editor |
| Mick O'Rourke | Stunts |
| Michael Mayers | Assistant Camera |
| Xavier Barquet | Stunts |
| Joe Ritter | Screenplay |
| Charles Kaufman | Creative Consultant |
| Barry Shapiro | Art Direction |
| Jennifer Aspinall | Special Effects Makeup Artist |
| Jeffrey Lee Gibson | Stunts |
| Stacy Kelley | Casting |
| Rhonda Krafchin | Casting |
| Alexandra Mazur | Art Direction |
| Aaron Nathanson | Sound Mixer |
| Stuart Strutin | Additional Writing |
| Stuart Strutin | Associate Producer |
| Christopher Burke | Additional Music |
| Tom Sierchio | Stunts |
| Tommy J. Huff | Stunts |
| Gay Partington Terry | Additional Writing |
| David Knox | Assistant Camera |
| Susan Starr | First Assistant Camera |
| Scott Leva | Stunt Coordinator |
| Scott Buckler | Lighting Director |
| Ray Abbott | Stunts |
| Tommy Louie | Boom Operator |
| Ralph Cordero | Special Effects Makeup Artist |
| Richard Hirsh | Assistant Editor |
| Patricia Brolsma | Boom Operator |
| J.D. Freedman | Electrician |
| Tom Lauten | Special Effects Makeup Artist |
| Steve Maiselson | Production Assistant |
| Nelson Vaughn | Production Supervisor |
| Joseph Solomito | First Assistant Director |
| Joseph Solomito | Production Executive |
| Joe Zubrovich | Second Assistant Director |
| Susanna Neuhaus | Assistant Art Director |
| Jim Reaven | Assistant Art Director |
| Mark Pancza | Sound Recordist |
| Robert Schoenholt | Sound Assistant |
| Mathew West | Special Effects Assistant |
| Brad Bryant | Stunts |
| Alex Harper | Stunts |
| Jeff Strutin | Stunt Driver |
| Chris Castillo | Key Grip |
| Denis Hahn | Camera Car |
| John Heron | Assistant Camera |
| Marc Kroll | Lighting Director |
| Bob Mackey | Grip |
| Ron Schlaeger | Loader |
| Alex Aurichio | Assistant Camera |
| Bryna Levin | Wardrobe Designer |
| Robert Keith Mecca | Assistant Editor |
| Alan J. Polyniak | Assistant Editor |
| Dan Sandberg | Colorist |
| Mark Greene | Location Manager |
| Alan Kohn | Transportation Captain |
| Eileen Nad Castaldi | Public Relations |
| Amy Hurley | Craft Service |
| Ira Kanarick | Production Accountant |
| Susan Kaufman | Creative Consultant |
| Gary Moscowitz | Production Accountant |
| Andy Stamatin | Craft Service |
| James C. Udel | Production Assistant |
