 | Brendan Fraser als Charlie |
 | Sadie Sink als Ellie |
 | Hong Chau als Liz |
 | Ty Simpkins als Thomas |
 | Samantha Morton als Mary |
 | Sathya Sridharan als Dan The Pizza Man |
 | Jacey Sink als Young Ellie |
 | Wilhelm Schalaudek als Liam (uncredited) |
| Mary Vernieu | Casting |
| Mark Friedberg | Production Design |
| Matthew Libatique | Director of Photography |
| Darren Aronofsky | Director |
| Darren Aronofsky | Producer |
| Lisa Scoppa | Set Decoration |
| Danny Glicker | Costume Design |
| Skip Lievsay | Sound Re-Recording Mixer |
| Ari Handel | Producer |
| Andrew Weisblum | Editor |
| Smokey Cloud | First Assistant Sound Editor |
| Adrien Morot | Prosthetic Designer |
| Inman Young | Head of Production |
| Jeremy Dawson | Producer |
| Lindsay Graham Ahanonu | Casting |
| Coll Anderson | Sound Effects Editor |
| Rob Simonsen | Original Music Composer |
| Tim Stipan | Digital Intermediate Colorist |
| William Sturtevant | Location Assistant |
| Scott Franklin | Executive Producer |
| Niko Tavernise | Still Photographer |
| Julia Ward | Finishing Producer |
| Alexandra Torterotot | Script Supervisor |
| Steve Baine | Foley Artist |
| Drew Kunin | Sound Mixer |
| Craig Henighan | Supervising Sound Editor |
| Jill Purdy | Supervising Sound Editor |
| Judy Chin | Makeup Department Head |
| Tyson Bidner | Executive Producer |
| Tyson Bidner | Unit Production Manager |
| Matt Marks | Property Master |
| Hilary Greer | Extras Casting |
| Maaike Snoep | Utility Sound |
| Jenny Foster | Production Coordinator |
| John Velez | Gaffer |
| Fred Kraemer | Special Effects Supervisor |
| Robert Pyzocha | Production Design |
| Annemarie Bradley | Hair Department Head |
| Andrew Silver | Music Editor |
| Rebecca West | Visual Effects Producer |
| Mitchell Andrew Lillian | Key Grip |
| Mark Goodermote | Boom Operator |
| Shane Shisheboran | Special Effects Makeup Artist |
| Bret Howe | Casting Associate |
| Patrick DeVine | Color Assistant |
| Chris Chae | Sound Re-Recording Mixer |
| Rowan Maher | Visual Effects Editor |
| Jane Ji | Props |
| Mandy Bisesti | Key Makeup Artist |
| Mike Drury | On Set Props |
| Zachary A. Schwartz | First Assistant Editor |
| Zac Gobetz | Finishing Producer |
| Brooks Lockwood | Best Boy Electric |
| Dexter Kennedy | Drone Pilot |
| James Hyde | ADR Mixer |
| Rachaell Dama | Costume Supervisor |
| Jack Lillian | Dolly Grip |
| Nicholas Figueroa | Editorial Staff |
| Jimmy DeMarco | Rigging Gaffer |
| Lauren Doner | Charge Scenic Artist |
| Chris Kocses | Production Coordinator |
| Greg Meola | Grip |
| Margaret Horning | Second Assistant Accountant |
| Duccio Fabbri | First Assistant Director |
| Rosa Garces | Payroll Accountant |
| Mariella Navarro | Art Department Coordinator |
| Morgan Heller | First Assistant Editor |
| Alice Johnson | Second Assistant Director |
| Hans Augustave | Key Production Assistant |
| Sophie-Ann Price | Visual Effects Producer |
| Jeff Flohr | Digital Imaging Technician |
| Michael Maida | Head of Production |
| Benjamin Bermudez | Casting Assistant |
| Anthony Stracquadanio | Grip |
| Matthew Fernandez | Visual Effects Producer |
| Jillian Fisher | Location Scout |
| Samuel D. Hunter | Screenplay |
| Samuel D. Hunter | Theatre Play |
| Hugh Brunt | Orchestrator |
| Hugh Brunt | Conductor |
| Bilali Mack | Visual Effects Supervisor |
| Sarah Brady Stack | Health and Safety |
| Tim Van Horn | VFX Artist |
| Jurasama Arunchai | Art Direction |
| Brendan Naylor | Associate Producer |
| Dylan Golden | Associate Producer |
| Jenna Roscoe | Dailies Operator |
| Nick Crist | Compositing Supervisor |
| Andrew Keogh Ruotolo | Post Production Supervisor |
| Danielle Guido | Art Department Production Assistant |
| Justin J. Jordan | Graphic Designer |
| Brendan Lowry | Dolly Grip |
| Neicy McFadden | Loader |
| Grgo Sevo | Camera Operator |
| Reid Zarker | Editorial Production Assistant |
| Fiona Cruickshank | Score Engineer |
| Clifton Harrison | Musician |
| Michelle Bayreuther | Set Medic |
| Michelle Bayreuther | Medical Consultant |
| Jeff Kryvicky | Title Designer |
| Tessa Lee | Production Assistant |
| David M. Night Maire | Production Assistant |
| Paula Paternostro | First Assistant Accountant |
| Allison Savoy | Production Assistant |
| Julie Velez | Production Accountant |
| Donald Francis | Key Hair Stylist |
