 | Johnny Depp als Dr. Will Caster |
 | Rebecca Hall als Evelyn Caster |
 | Morgan Freeman als Joseph Tagger |
 | Paul Bettany als Max Waters |
 | Cillian Murphy als Agent Donald Buchanan |
 | Kate Mara als Bree |
 | Cole Hauser als Colonel Stevens |
 | Clifton Collins Jr. als Martin |
 | Sam Quinn als Meth Head #2 |
 | Cory Hardrict als Joel Edmund |
 | Falk Hentschel als Bob |
 | Josh Stewart als Paul |
 | Luce Rains als Roger |
 | Fernando Chien als Heng |
 | Steven Liu als Chiu |
 | Lukas Haas als James Thomas |
 | Xander Berkeley als Dr. Thomas Casey |
 | Wallace Langham als Dr. Strauss |
 | James Burnett als Meth Head #1 |
| Sam Webb als Red Hooded Teenager |
 | Chris Gartin als Tech Conference Coordinator |
 | Olivia Taylor Dudley als Groupie |
 | Abe Martell als RIFT Hacker |
| Lauren Sivan als Reporter |
| Laramie Cooley als BDC Greeter |
 | Nancy Jeris als BDC Servant |
| Colin Jones als FBI Agent |
 | Dylan Kenin als FBI Agent |
 | Chad Brummett als Solar Field Worker |
 | Antonio Del Prete als Will In Hybrid |
| Jon Kristian Moore als Will In Hybrid |
| John Trejo als Special Forces on Roof |
| Darren P. Leis als Medical Lab Tech |
| Donna Brown als RIFT Surgeon |
| Richard Daniel Williams als RIFT Surgeon |
| Zack Carpenter als RIFT Medical Tech |
| Christina Lancellotti als RIFT Medical Tech |
 | Kristen Rakes als MIT Programmer |
 | Seth Adkins als Miserable Student |
| Jaime Powers als Hybrid Townsman (uncredited) |
| Lubella Gauna als Nurse (uncredited) |
| Lyn Quinn als Tech Conference Attendee (uncredited) |
 | Kendra Tuthill als Townswoman (uncredited) |
| Darrick Hurst als Berkeley Student (uncredited) |
 | Dennis Keiffer als Hybrid Soldier (uncredited) |
 | Elon Musk als Elon Musk (uncredited) |
| Fergaledgar als John Mccarthy (uncredited) |
| Mark A. Mangini | Sound Designer |
| David Valdes | Producer |
| Christopher Nolan | Executive Producer |
| Aaron Ryder | Producer |
| Emma Thomas | Executive Producer |
| Wally Pfister | Director |
| John Papsidera | Casting |
| Richard L. Anderson | Sound Effects Editor |
| Sala Baker | Stunts |
| Mychael Danna | Original Music Composer |
| Gene Serdena | Set Decoration |
| George L. Little | Costume Design |
| Wade Allen | Stunt Coordinator |
| David Rosenbloom | Editor |
| Susan McNamara | Unit Production Manager |
| Goro Koyama | Foley |
| Scott Herbertson | Set Designer |
| Broderick Johnson | Producer |
| Andrew A. Kosove | Producer |
| Joe Bucaro III | Stunts |
| Dawn Swiderski | Supervising Art Director |
| Caitlin McKenna | ADR Voice Casting |
| Mark Vargo | Second Unit Director of Photography |
| Chris Seagers | Production Design |
| Jo Edna Boldin | Casting |
| Jess Hall | Director of Photography |
| Joel Harlow | Makeup Artist |
| Jan Foster | Unit Production Manager |
| Vanessa Sharp | Hairstylist |
| Nancy Deren | Set Designer |
| Marisa Polvino | Producer |
| Deanna Brigidi | Casting Associate |
| Douglas Shamburger | Boom Operator |
| Jonas Spaccarotelli | Second Assistant Director |
| Yolanda T. Cochran | Co-Producer |
| Jack Paglen | Writer |
| Kate Cohen | Producer |
| Annie Marter | Producer |
| Mary Regency Boies | Co-Producer |
| Scott Robertson | Co-Producer |
| Scott Robertson | First Assistant Director |
| Mike Chambers | Visual Effects Producer |
| Gregory S. Hooper | Art Direction |
| Jim Ford | Stunts |
| Cory Geryak | Chief Lighting Technician |
| Robert Q. Mathews | Costume Supervisor |
| Luisa Abel | Makeup Department Head |
| Tom Frohling | Art Direction |
| Bjarne Sletteland | Art Direction |
| Ed Duran | Stunts |
| Sylvain Lasseur | Sound Effects Editor |
| Nathan McGuinness | Visual Effects Supervisor |
| Lori A. Balton | Location Scout |
| Clint Wallace | Art Direction |
| Richard K. Buoen | Conceptual Design |
| Susannah Carradine | Art Department Coordinator |
| Victor James Martinez | Conceptual Design |
| Aric Cheng | Set Designer |
| Timothy M. Earls | Set Designer |
| Jerome Brett Fairchild | Greensman |
| Ricardo Guillermo | Set Designer |
| Jeff Julian | Conceptual Design |
| Mallorie McConnell | Sculptor |
| Candice Muriedas | Art Department Coordinator |
| Siobhan Roome | Set Designer |
| Grant Samson | Leadman |
| Andrew M. Siegel | Property Master |
| David V. Butler | Dialogue Editor |
| Sandra Fox | Foley |
| Tim Walston | Sound Designer |
| Scott R. Fisher | Special Effects Coordinator |
| Darrin Prescott | Stunt Coordinator |
| P. Scott Sakamoto | Steadicam Operator |
| P. Scott Sakamoto | "A" Camera Operator |
| Corey Bronson | Set Costumer |
| Laurel Frushour | Set Costumer |
| Erich Stratmann | Music Editor |
| Denny Caira | Transportation Coordinator |
| James Waitkus | Transportation Captain |
| Justin Ferk | Location Manager |
| Paul B. Roberts | Location Scout |
| Derrick Mitchell | Visual Effects Editor |
| Craig Hosking | Aerial Coordinator |
| Craig Hosking | Pilot |
| Brendan Walsh | Assistant Editor |
| Gregory M. Edgar | Armorer |
| Kenn Smiley | Key Costumer |
| Peter Mountain | Still Photographer |
| Sharron Reynolds-Enriquez | Script Supervisor |
| Hans Bjerno | Aerial Director of Photography |
| Brad Arensman | Associate Producer |
| Josh Bleibtreu | Second Unit Director of Photography |
| Jesse Trevino | Ager/Dyer |
| Candice D. Campos | Production Supervisor |
| Anthony Gaudioz | "B" Camera Operator |
| Steve Koster | Aerial Director of Photography |
| James R. Tynes | Gaffer |
| Jay Wejebe | Key Makeup Artist |
| Dane Bjerno | Aerial Camera Technician |
| Maggie Hayes-Jackson | Hairstylist |
| James Logan | Stunts |
| Lamarr Gray | Rigging Gaffer |
| Jon Shroyer | Makeup Artist |
| Trystan James | Animation |
| Brian N. Bentley | Compositors |
| Eric Dvorsky | Aerial Camera Technician |
| Eric Yake | Ager/Dyer |
| Khanh Trance | Wigmaker |
| John Trejo | Stunts |
| Roberta Bilé | Key Costumer |
| Jonny Winograd | First Assistant Editor |
| Marie A. Kohl | Casting Associate |
| Bob Hall | First Assistant "A" Camera |
| Blake Pike | Rigging Grip |
| Philip Shanahan | First Assistant "B" Camera |
| Deva Anderson | Music Supervisor |
| Al Goto | Stunts |
| Sze Jia Eng | Visual Effects Coordinator |
| Byron Wilson | ADR Supervisor |
| Paula Suhy | Assistant Editor |
| Russell Cannon | Armorer |
| Michael Panevics | Armorer |
| Rachel Bris | Ager/Dyer |
| Teri Ann Uccan | Hairstylist |
| Eunice Khoo | Visual Effects Coordinator |
| Jeremy Fry | Stunt Driver |
| Dhamarata Dhiensuwana | Rigging Grip |
| Rick Shuster | Pilot |
| Lea E. Miller | Dolly Grip |
| Bruce Benson | Pilot |
| Carol Demarti | Ager/Dyer |
| Dan Schroer | Second Assistant "A" Camera |
| Michael Struk | Visual Effects Editor |
| Kentaro Yano | Makeup Artist |
| Peggy Pere | Aerial Coordinator |
| Kevin M. Miller | Rigging Grip |
| Liu Bing | Camera Production Assistant |
| Maximillian McNair MacEwan | Visual Effects Coordinator |
| Simon Pynn | Matchmove Supervisor |
| Ray Garcia | Key Grip |
| Stuart Slack | Key Grip |
| Clayton Null | Key Grip |
| Christopher H. Sipes | Rigging Grip |
| Scott Wetzel | Video Assist Operator |
| Joy Ramsay | Set Costumer |
| Stephen P. Arkle | Digital Intermediate |
| Jim Hall | Negative Cutter |
| Phyllis Hart | Negative Cutter |
| John Arbuckle | Marine Coordinator |
| Daniel Baldwin | 3D Animator |
| Alexander Seaman | CG Supervisor |
| Ryan Wehner | Title Designer |
| Sean Rowe | Matchmove Supervisor |
| Arron Roebuck | Modeling |
| Jason Lee Brown | Modeling |
| Katie Stetson | Visual Effects Coordinator |
| Genevieve Claire | Visual Effects Coordinator |
| Muhittin Bilginer | Visual Effects Technical Director |
| Jonathan Clark | Camera Loader |
| Ryan Bushman | Second Assistant "B" Camera |
| Dan Mintz | Executive Producer |
