 | Anthony Ramos als Noah Diaz |
 | Dominique Fishback als Elena Wallace |
 | Luna Lauren Velez als Mrs. Diaz |
 | Dean Scott Vazquez |
 | Tobe Nwigwe als Reek |
 | Peter Cullen als Optimus Prime (voice) |
 | Ron Perlman als Optimus Primal (voice) |
 | Peter Dinklage als Scourge (voice) |
 | Michelle Yeoh als Airazor (voice) |
 | Liza Koshy als Arcee (voice) |
 | John DiMaggio als Stratosphere / Transit (voice) |
 | David Sobolov als Rhinox / Battletrap (voice) |
 | Michaela Jaé Rodriguez als Nightbird (voice) |
 | Pete Davidson als Mirage (voice) |
 | Cristo Fernández als Wheeljack (voice) |
 | Tongayi Chirisa als Cheetor (voice) |
 | Colman Domingo als Unicron (voice) |
 | Michael Kelly |
| Steven Spielberg | Executive Producer |
| Michael Bay | Producer |
| Don Murphy | Producer |
| Patrick Tatopoulos | Production Design |
| Duncan Henderson | Producer |
| Lorenzo di Bonaventura | Producer |
| Chantal Feghali | Visual Effects Producer |
| Enrique Chediak | Director of Photography |
| Tom DeSanto | Producer |
| Brian Goldner | Executive Producer |
| Mark Vahradian | Producer |
| Brad Fischer | Executive Producer |
| Dana Goldberg | Executive Producer |
| Don Granger | Executive Producer |
| Brian Oliver | Executive Producer |
| David Ellison | Executive Producer |
| Joby Harold | Screenplay |
| Joby Harold | Story |
| Erich Hoeber | Screenplay |
| Jon Hoeber | Screenplay |
| Vaia Zaganas | Stunts |
| Jen Weissenberg | Stunt Driver |
| Philippe Lord | Art Direction |
| Ann Smart | Set Decoration |
| Colleen Quinton | Makeup Designer |
| Mathieu Giguère | Art Direction |
| Rodney Alexandre | Stunt Driver |
| Steven Caple Jr. | Director |
| Alvin Zalamea | Stunt Double |
| Jongnic Bontemps | Original Music Composer |
| Ciara Whaley | Costume Design |
| Nitasha Bhambree | Stunt Driver |
| Adam Winlove-Smith | Stunt Driver |
| Stephannie Hawkins | Stunt Driver |
| E. Nova Zatzman | Stunt Driver |
| Vanessa Zamarripa | Stunts |
| Valerii An | Executive Producer |
| Darnell Metayer | Screenplay |
| Josh Peters | Screenplay |
| Kye Walstrom | Stunt Driver |
