 | Anthony Ramos als Noah Diaz |
 | Dominique Fishback als Elena Wallace |
 | Peter Cullen als Optimus Prime (voice) |
 | Ron Perlman als Optimus Primal (voice) |
 | Peter Dinklage als Scourge (voice) |
 | Michelle Yeoh als Airazor (voice) |
 | Pete Davidson als Mirage (voice) |
 | Liza Koshy als Arcee (voice) |
 | Cristo Fernández als Wheeljack (voice) |
 | Luna Lauren Velez als Breanna Diaz |
 | Dean Scott Vazquez als Kris Diaz |
 | Tobe Nwigwe als Reek |
 | Sarah Stiles als Jillian |
 | Leni Parker als Ms. Greene |
 | Frank Marrs als Receptionist |
 | Aidan Devine als Bishop |
 | Kerwin Jackson als Hotel Security Guard |
 | Mike Chute als NYC Police Officer |
 | Tyler Hall als NYC Police Officer |
 | Sean Tucker als Bridge Security Guard |
| Jay Farrar als Museum Guard |
| Lucas Huarancca als Amaru |
 | Amiel Cayo als Amaru's Son |
| Santusa Cutipa als Amaru's Wife |
| Yesenia Inquillay als Amaru's Granddaughter |
| Sumac T'Ika als Amaru's Granddaughter |
| Josue Sallo als Amaru's Grandson |
| Mellissa Alvarez als Amaru's Daughter-In-Law |
| Gloria Cusi als Amaru's Relative |
 | Michael Kelly als Agent Burke |
| Jason D. Avalos als Security Guard |
 | Lesley Stahl als Lesley Stahl |
 | John DiMaggio als Transit / Stratosphere (voice) |
 | David Sobolov als Rhinox / Battletrap / Apelinq (voice) |
 | Michaela Jaé Rodriguez als Nightbird (voice) |
 | Colman Domingo als Unicron (voice) |
 | Tongayi Chirisa als Cheetor (voice) |
 | Luke Jones als Additional Voice (voice) |
| Joby Harold | Screenplay |
| Steven Caple Jr. | Director |
| Lorenzo di Bonaventura | Producer |
| Enrique Chediak | Director of Photography |
| Valerii An | Executive Producer |
| Mark Vahradian | Producer |
| Steven Spielberg | Executive Producer |
| Brian Oliver | Executive Producer |
| Don Granger | Executive Producer |
| Brian Goldner | Executive Producer |
| Dana Goldberg | Executive Producer |
| Brad Fischer | Executive Producer |
| David Ellison | Executive Producer |
| Mathieu Giguère | Art Direction |
| Philippe Lord | Art Direction |
| Ann Smart | Set Decoration |
| Ciara Whaley | Costume Design |
| Colleen Quinton | Makeup Designer |
| Chantal Feghali | Visual Effects Producer |
| Duncan Henderson | Producer |
| Michael Bay | Producer |
| Darnell Metayer | Screenplay |
| Josh Peters | Screenplay |
| Erich Hoeber | Screenplay |
| Jon Hoeber | Screenplay |
| Joby Harold | Story |
| Stephannie Hawkins | Stunt Driver |
| Rodney Alexandre | Stunt Driver |
| Nitasha Bhambree | Stunt Driver |
| E. Nova Zatzman | Stunt Driver |
| Vanessa Zamarripa | Stunts |
| Alvin Zalamea | Stunt Double |
| Vaia Zaganas | Stunts |
| Adam Winlove-Smith | Stunt Driver |
| Jen Weissenberg | Stunt Driver |
| Kye Walstrom | Stunt Driver |
| Tom DeSanto | Producer |
| Don Murphy | Producer |
| Jongnic Bontemps | Original Music Composer |
| Frédéric Bélanger | Hair Department Head |
| Eli Girard | Hairstylist |
| Nathalie Legault | Makeup Artist |
| Melissa Puch | Makeup Artist |
| Soraya Qadi | Key Hair Stylist |
| William Goldenberg | Editor |
| Joel Negron | Editor |
| Wittney Horton | Casting |
| Frédéric Berthiaume | Art Direction |
| Ève Boulonne | Art Direction |
| Caroline Davignon | Art Direction |
| Marie-Soleil Dénommé | Art Direction |
| Arthur Jongewaard | Art Direction |
| Michele Laliberte | Supervising Art Director |
| Félix Larivière-Charron | Supervising Art Director |
| Louis Dandonneau | Set Decoration |
| Brent David Mannon | Set Decoration |
| Michael Nallan | Set Decoration |
| Geneviéve Duguay | Third Assistant Director |
| Clara Haddad | Third Assistant Director |
| Cliff Lanning | First Assistant Director |
| Anthony Leonardi III | Second Unit Director |
| James Madigan | Second Unit Director |
| Dale Byrns | Set Designer |
| Clothilde Caillé-Levesque | Set Designer |
| Manuel Charbonneau | Set Dresser |
| Shoko Kambara | Assistant Art Director |
| Travis Nunnally | Set Dresser |
| Dennis Ogle | Set Decoration Buyer |
| Georges Samuel | Set Dresser |
| Eduardo Santibanez | Set Dresser |
| Radia Slaimi | Set Designer |
| Simon Théberge | Set Designer |
| Erik Aadahl | Supervising Sound Editor |
| Erik Aadahl | Sound Designer |
| Felix Andrew | Sound Mixer |
| Gui DaSilva-Greene | Stunts |
| Esteban Sánchez | Second Assistant Director |
| Tim Trella | Stunt Coordinator |
| Tom Elliott | Stunts |
| Dena Sodano | Stunts |
| Corey Michael Eubanks | Stunt Driver |
| Amy Szoke | Stunts |
| Sean Haworth | Production Design |
| Shoji Kawamori | Original Story |
| Kazutaka Miyatake | Original Story |
| Anisha Gibbs | Stunts |
