 | Bruce Willis als James Cole |
 | Madeleine Stowe als Dr. Kathryn Railly |
 | Brad Pitt als Jeffrey Goines |
 | Christopher Plummer als Dr. Goines |
 | David Morse als Dr. Peters |
 | Jon Seda als Jose |
 | Christopher Meloni als Lt. Halperin |
 | Joey Perillo als Detective Franki |
 | LisaGay Hamilton als Teddy |
 | Matt Ross als Bee |
 | Annie Golden als Woman Cabbie |
 | Michael Chance als Scarface |
| H. Michael Walls als Botanist |
 | Bob Adrian als Geologist |
 | Bill Raymond als Microbiologist |
 | Ernest Abuba als Engineer |
| Nell Johnson als Ward Nurse |
| Rozwill Young als Billings |
| Joseph Melito als Young Cole |
 | Frank Gorshin als Dr. Fletcher |
| Aaron Michael Lacey als WWI Sergeant |
 | Vernon Campbell als Tiny |
 | Simon Jones als Zoologist |
 | Carol Florence als Astrophysicist / Jones |
 | Irma St. Paule als Poet |
 | Frederick Strother als L.J. Washington |
 | Charles Techman als Professor |
| Rick Warner als Dr. Casey |
| Anthony 'Chip' Brienza als Dr. Goodin |
| Bruce Kirkpatrick als Policeman No. 1 |
| Wilfred Williams als Policeman No. 2 |
| Joilet Harris als Harassed Mother |
| Drucie McDaniel als Waltzing Woman Patient |
| John Blaisse als Old Man Patient |
 | Louis Lippa als Patient at Gate |
 | Stan Kang als X-Ray Doctor |
| Pat Dias als WWI Captain |
 | Felix Pire als Fale |
| Karl Warren als Pompous Man |
 | Joseph McKenna als Wallace |
 | Stephen Bridgewater als Airport Detective |
| Ray Huffman als Plump Businessman |
 | Charley Scalies als Impatient Traveler |
| Paul Meshejian als Detective Dalva |
| Kevin Thigpen als Kweskin |
 | Jann Ellis als Marilou |
 | Michael Ryan Segal als Weller |
 | Korchenko als Thug No. 1 |
| Robert O'Neill als Wayne |
| Harry O'Toole als Louie / Raspy Voice |
 | Chuck Jeffreys als Thug No. 2 |
| Barry Price als Agent No. 1 |
| John Panzarella als Agent No. 2 |
| Janet Zappala als Anchorwoman |
| Lisa Talerico als Ticket Agent |
| Tiffany Baldwin als Student in Airport (uncredited) |
| C.J. Byrnes als Psychiatric Patient (uncredited) |
| Tom Detrik als FBI Agent (uncredited) |
| Joe Gerety als Sprayer (uncredited) |
| Bonnie Loev als Time Portal Nurse (uncredited) |
 | Raymond Mamrak als Travler (uncredited) |
 | Allelon Ruggiero als Inpatient (uncredited) |
| Thang als Monkey Member (uncredited) |
| Sal Mazzotta als Prisoner Joey (uncredited) |
 | Bart the Bear als Bear |
 | Donald Faison als Psychiatric Prisoner (uncredited) |
 | Richard Stanley als Man in Transit Lounge (uncredited) |
| Charles Roven | Producer |
| William Ladd Skinner | Art Direction |
| Robert Cavallo | Executive Producer |
| Janet Peoples | Screenplay |
| Margery Simkin | Casting |
| Roger Pratt | Director of Photography |
| Crispian Sallis | Set Decoration |
| Gary Levinsohn | Executive Producer |
| Paul Buckmaster | Original Music Composer |
| Jeffrey Beecroft | Production Design |
| Imogen Pollard | Sound Editor |
| Terry Gilliam | Director |
| David Webb Peoples | Screenplay |
| Robert Kosberg | Executive Producer |
| Mick Audsley | Editor |
| Julie Weiss | Costume Design |
| Kelley Smith-Wait | Associate Producer |
| Mark Egerton | Associate Producer |
| Lloyd Phillips | Co-Producer |
| Richard Bain | Digital Compositors |
| G. A. Aguilar | Stunts |
| Steve Martin | Stunt Coordinator |
| Peter Norman | Camera Operator |
| Marc Diener | Legal Services |
| Warren Holcomb | Legal Services |
| Lê Hoàng | Carpenter |
| Randy Smith | Boom Operator |
| David S. Lomax | Stunts |
| Bill Fiedler | Electrician |
| Eric H. Sandberg | Costume Supervisor |
| Eddie Wilder | Color Timer |
| Gary Pugh | Carpenter |
| Martin Body | Digital Compositors |
| Keith Salkowski | Electrician |
| B.J. Rogers | Assistant Costume Designer |
| Christina Bartolucci | Hairstylist |
| Christine Beveridge | Hair Designer |
| Ted Lubonovich II | Carpenter |
| Paul A. Minitello | Painter |
| Jack Stew | Foley |
| Doug Forrest | Digital Compositors |
| Susi Roper | Visual Effects Coordinator |
| Ronald O. Jaynes | Stunts |
| Mike Finnegan | Rigging Grip |
| Mikie Heilbrun | Casting Associate |
| Ernie Malik | Unit Publicist |
| Kevin Ishioka | Assistant Art Director |
| Lara Kelly | Art Department Coordinator |
| John D. Kretschmer | Leadman |
| Paul Maiello | Carpenter |
| Bill Anagnos | Stunts |
| Kyle Rudolph | Camera Operator |
| Larry Misselhorn | Greensman |
| Jason Swanscott | Foley |
| Robert LaPrell | Assistant Art Director |
| David Cecil | Electrician |
| Ian Kelly | Video Assist Operator |
| Russell Hurlburt | Special Effects |
| Dan Gane | First Assistant Editor |
| Steve Cutmore | Digital Compositors |
| Douglas Crosby | Stunts |
| Elizabeth J. Nevin | Production Coordinator |
| Chuck Jeffreys | Stunts |
| Pamela Susan Hall | Post Production Assistant |
| William A. Kohout | Hairstylist |
| Russell Hardee | Special Effects |
| Vinnie Gerardo | First Assistant Camera |
| Carole French | Craft Service |
| Matilde Valera | Production Accountant |
| Tim Galvin | Assistant Art Director |
| James Healy | Special Effects |
| Shirley Montefusco | Special Effects Coordinator |
| Chris Panton | Digital Compositors |
| Sandy Alexander | Stunts |
| Phillip V. Caruso | Still Photographer |
| Steven Lane Ewing | Construction Coordinator |
| Rick Gamez | Propmaker |
| Kent Houston | Visual Effects Supervisor |
| Thomas Greco | Loader |
| Dennis Davidson | Public Relations |
| Allen Weisinger | Makeup Artist |
| Wayne Smith | Standby Painter |
| Peter Joly | Supervising Sound Editor |
| David Acord | Special Effects |
| Paul Couch | Stunts |
| Craig Haagensen | Camera Operator |
| Lee Shapira | Grip |
| Elena Moscatt | Craft Service |
| Carl Catanese | Leadman |
| Wesley Goodwin | Carpenter |
| Scott T. Pina | Carpenter |
| E.J. Evans | Stunts |
| Rhett Bloomquist | Grip |
| Andrew Reed Conner | Electrician |
| Blackford 'Boots' Shelton | First Assistant Camera |
| Lucy Darwin | Post-Production Manager |
| Beecher Tomlinson | Special Effects |
| Marilyn Bailey | Script Supervisor |
| Ted Criswell | Set Medic |
| Glen Foster | Carpenter |
| Mark Kendig | Carpenter |
| John Copeman | Stunts |
| Steve Martin | Stunts |
| Craig Ligget | Rigging Gaffer |
| Matt Miller | Rigging Grip |
| Brian Snell | Grip |
| Reva Grantham | Craft Service |
| Avi Korein | Security |
| Charley Armstrong | Location Scout |
| Paul Kocar | Special Effects |
| Thomas Lockey | Special Effects |
| Joseph P. Mercurio | Special Effects |
| Anthony Simonaitis | Special Effects Supervisor |
| Steve Santosusso | Stunts |
| Brian Smyj | Stunts |
| Brian Ufberg | First Assistant Editor |
| Elliot Santiago | Stunts |
| Glynn Williams | Post Production Assistant |
| Scott Elias | Location Manager |
| Peggy Nicholson | Key Hair Stylist |
| Richard Curry | Driver |
| Matt Codd | Production Illustrator |
| Silvija L. Moess | Scenic Artist |
| Thomas Turnbull | Construction Foreman |
| Lloyd Phillips | Unit Production Manager |
| Penny Causer | Title Designer |
| Kate Bartouldus | Set Dresser |
| Trevor Collins | Negative Cutter |
| Chuck Finch | Chief Lighting Technician |
| Ian Wilson | Foley Editor |
| Tasha Pym | Apprentice Sound Editor |
| Scott Maginnis | Assistant Property Master |
| Patrick McGrath | Dolly Grip |
| Mark Egerton | First Assistant Director |
| Mark Berrow | Musician |
| Simon Cozens | Assistant Sound Editor |
| Marissa Giunta | Casting Assistant |
| Melissa Stanton | Wardrobe Supervisor |
| Jim Clubb | Animal Coordinator |
| Budge Tremlett | ADR Editor |
| Charles Miller | Assistant Production Manager |
| Ken Tarallo | Pyrotechnician |
| Mike Miller | Key Grip |
| Andrew Bernstein | Second Assistant Director |
| Danny Longhurst | Dialogue Editor |
| Jay Meagher | Sound Mixer |
| Doug Harlocker | Property Master |
| Philip A. Patterson | Second Assistant Director |
| Susan Gish | Extras Casting |
| Kathi Ash | Assistant Location Manager |
| John 'JR' Craigmile | Payroll Accountant |
| Gary Pilkinton | Special Effects Technician |
| Thomas Jirgal | Best Boy Grip |
| Eric McClain | Colorist |
| Richard Suckle | Production Executive |
| Valerie Bartlett | Production Secretary |
| Ted Swanscott | Foley Recordist |
| Marina Marit | Costumer |
| Diane Greaves | Foley Artist |
| Tim Downs | Location Production Assistant |
| Steven Litecky | Assistant Chief Lighting Technician |
| Terry Jackson | Stunt Double |
| Thomas J. O'Connell | ADR Mixer |
| Robert Holtzman | Set Buyer |
| Bill Gerardo | Second Assistant Camera |
| Amanda Pollack | Assistant Editor |
| William Jones | Grip |
| Mike Lemon | Local Casting |
| Alex Brown | Production Assistant |
| Chris Marker | Original Film Writer |
| James Kelley | Set Dresser |
