 | Milla Jovovich als Violet Song Jat Shariff |
 | Cameron Bright als Six |
 | Nick Chinlund als Ferdinand Daxus |
 | Sebastien Andrieu als Nerva |
 | Ida Martin als Young Violet |
 | William Fichtner als Garth |
 | David E. Collier als BF-1 |
| Kieran O'Rorke als Detective Cross |
 | Digger Mesch als Detective Endera |
 | Ryan Martin als Detective Breeder |
 | Steven Calcote als Young Daxus |
| Ricardo Mamood-Vega als Violet's Husband |
 | Mike Smith als Hospital Hemophage |
 | Clay Cullen als Rebel Hemophage |
| Jennifer Caputo als Elizabeth P. Watkins |
| Jack Murphy als Chief of Staff |
| Diego Swing als Daxus Aide 1 |
| Theodore Thomas als Daxus Aide 2 |
 | Abraham Boyd als L.L.D.D. Guard |
 | Matthew Sturgess als Medical Tech 1 |
 | Kurt Wimmer als Speak-No-Evil Phage |
 | Russell Wait als Combat Reserve Doctor |
 | Duc Luu als Kar Wai |
 | Ian Streetz als Hemophage (uncredited) |
| Klaus Badelt | Original Music Composer |
| Peter Brown | Sound Designer |
| Peter Brown | Supervising Sound Editor |
| Peter Brown | Sound Effects Designer |
| Dean Beville | Sound Editor |
| Justine Baddeley | Casting |
| Joseph A. Porro | Costume Design |
| Desmond Cannon | Post Production Supervisor |
| Calvin Roberts | Digital Imaging Technician |
| Ezra Dweck | Sound Re-Recording Mixer |
| Kurt Wimmer | Director |
| Kurt Wimmer | Writer |
| Andy Armstrong | Technical Advisor |
| Bernardo Trujillo | Supervising Art Director |
| Roberto Bonelli | Set Designer |
| Tony Mark | Executive Producer |
| Tony Mark | Unit Production Manager |
| Tony Mark | Second Unit Director |
| Arthur Wong Ngok-Tai | Director of Photography |
| Gemma Waugh | Makeup Artist |
| Gemma Waugh | Hairstylist |
| John Baldecchi | Producer |
| Pauline Chan | Producer |
| Sue Jett | Executive Producer |
| Wan Allen | Line Producer |
| Rita Fung | Line Producer |
| Wai Sum Shia | Line Producer |
| T.C. Wang | Executive Producer |
| William Yeh | Editor |
| Charles Wang | Executive Producer |
| Louis Sit | Co-Producer |
| Choo Sung Pong | Production Design |
| Chung Kim Wai | Set Decoration |
| Chong Kwok-Wing | Art Direction |
| Steven Calcote | Visual Effects Producer |
| Jennifer Caputo | Stunt Double |
| Raymond Lam | Steadicam Operator |
| Wolfram de Marco | Music Arranger |
| Phil Jones | First Assistant Director |
| Mark A. Kolars | Compositing Supervisor |
| Michael Eaves | Digital Intermediate Colorist |
| Stephen Hunter Flick | Supervising Sound Editor |
| Mark Lambert Bristol | Storyboard Artist |
| Antonia Barnard | Production Supervisor |
| Kim Davis-Wagner | Casting |
| Gary A. Hecker | Special Sound Effects |
| Randall Archer | Utility Stunts |
| Scott Piper | Boom Operator |
| Dave Porter | Additional Music |
| James Matheny | Sound Editor |
| Marie Nardella | Makeup Artist |
| Cori Burchell | Assistant Costume Designer |
| Daniel Arrias | Stunts |
| Margit Pfeiffer | Assistant Sound Editor |
| Julie Orosz | Executive Visual Effects Producer |
| Edward M. Steidele | Foley Artist |
| Jay Maidment | Still Photographer |
| Jay Cheng | Key Costumer |
| Corey Pritchett | Special Effects |
| Larry Kemp | ADR Editor |
| Jonathan Wales | Sound Re-Recording Mixer |
| Steven Ticknor | Sound Effects Designer |
| Julia Neighly | Production Coordinator |
| Lisa Tutunjian | Digital Intermediate Editor |
| Renee Burke | Script Supervisor |
| Brian Richards | Music Editor |
| Moira Houlihan | Unit Publicist |
| Neil Greenberg | Visual Effects Producer |
| Richard Burton | Sound Effects Editor |
| Flax Glor | Publicist |
| Darrell Pritchett | Special Effects Coordinator |
| Jason Wardle | CG Supervisor |
| Dana Gustafson | Sound Editor |
| Mike Smith | Stunt Coordinator |
| Mike Smith | Fight Choreographer |
| Jimmy Wong | Camera Operator |
| Robert Alonzo | Stunt Coordinator |
| Howard London | ADR Mixer |
| Christopher Brooks | Music Editor |
| Jamie Pritchard | Hairstylist |
| Maria Gonzales | First Assistant Editor |
| Kirsten Anderson | First Assistant Accountant |
| Matthew C. Beville | Foley Mixer |
| Natasha Leonnet | Digital Color Timer |
| Madalena Chan | Local Casting |
| Mo Henry | Negative Cutter |
| Gary Abrahamian | CG Artist |
| Jason Faulkner | Second Assistant Director |
| Victor Wong | Visual Effects Supervisor |
| Ho Ching | Production Supervisor |
| Johnny Lee | Production Manager |
| Petrina Ho | Production Manager |
| Luo Gang | Production Manager |
| Rufina Lo | Set Designer |
| Johnny Wang | Art Department Coordinator |
| Hana Espinoza | Art Department Coordinator |
| Stanley Hung | Camera Operator |
| Jackie Cheng | Set Costumer |
| Jack Tung | Costume Coordinator |
| Meinir Jones-Lewis | Key Hair Stylist |
| Meinir Jones-Lewis | Key Makeup Artist |
| Chow Lam | Chief Lighting Technician |
| Cheung Kwok Wah | Rigging Gaffer |
| Ben Chau | Key Grip |
| Alexandra Taussig | Production Coordinator |
| Miao Liang | Local Casting |
| Catherine Engel | Casting Associate |
| Casey Pritchett | Special Effects Supervisor |
| Monica Sandstede | Story Editor |
| Bob Fernley | Digital Intermediate Producer |
| Rick Remender | Production Illustrator |
| Don Guarisco | Research Assistant |
| Peggy Lee | Production Controller |
| Jayni Borgaro | Compositor |
| Michelle McGonagle | Second Second Assistant Director |
| Joyce Hsieh | Production Accountant |
| Aaron Shershow | Unit Manager |
| William Kan | Assistant Art Director |
| Keith Giesbrecht | Craft Service |
| Yaozu Huang | Technical Supervisor |
| Rongguo Fang | Visual Effects Supervisor |
| Jack Ho | Visual Effects Coordinator |
| Ronald Yeung | Assistant Hairdresser |
| Jason Fu | Assistant Makeup Artist |
| Margie Beattie | Additional Second Assistant Director |
| Noah Weinzweig | Camera Operator |
| Stephanie Cheung | Third Assistant Director |
| Chor Keung Chan | "A" Camera Operator |
| Cheuk Kau Man | Location Manager |
| Johnathan Chan | Second Assistant "B" Camera |
| Yong Shen | Senior Animator |
| Aaron Ho | Casting Assistant |
| Scottpatrick J. Sellitto | Music Consultant |
| Marilyn Zhuang | Assistant Accountant |
| Regaye Fulcher | Production Assistant |
| Lanny Dong | Production Secretary |
| Bob Clayton | Sound Mixer |
