 | John Candy als Buck Russell |
 | Jean Louisa Kelly als Tia Russell |
 | Gaby Hoffmann als Maizy Russell |
 | Macaulay Culkin als Miles Russell |
 | Amy Madigan als Chanice Kobolowski |
 | Elaine Bromka als Cindy Russell |
 | Garrett M. Brown als Bob Russell |
 | Laurie Metcalf als Marcie Dahlgren-Frost |
 | Jay Underwood als Bug |
 | Brian Tarantina als E. Roger Coswell |
 | Mike Starr als Pooter-the-Clown |
 | Suzanne Shepherd als Mrs. Hogarth |
 | William Windom als Mr. Hatfield (voice) |
 | Dennis Cockrum als Pal |
 | Joel Robinson als Miles' Friend #1 |
| Colin Baumgartner als Miles' Friend #2 |
| Erik Whipple als Miles' Friend #3 |
 | Mark Rosenthal als Party Boy #1 |
| Doug von Nessen als Party Boy #2 |
 | Wayne Kneeland als Party Boy #3 |
| Gigi Casler als Party Girl in Bedroom |
 | LaVerne Anderson als Party Girl #1 |
| Gina Doctor als Party Girl #2 |
| Rachel Thompson Perrine als Party Girl #3 |
| Ron Payne als Maizy's Teacher |
| Jane Vickerilla als Teacher |
| Kyle Lewis Eastman als School Child |
| Dana Taylor als School Child |
| Jennifer Kane als School Child |
| Christen Loftis als School Child |
| Genae Affrunti als School Child |
 | Anna Chlumsky als School Child |
 | Patricia Arquette als Additional Voices (voice) |
 | Jack Blessing als Additional Voices (voice) |
 | Devon Odessa als Additional Voices (voice) |
| Ryan Goldstein als School Child (uncredited) |
| John Hughes | Director |
| John Hughes | Producer |
| Tom Jacobson | Producer |
| Ira Newborn | Original Music Composer |
| Ralf D. Bode | Director of Photography |
| Lou Lombardo | Editor |
| Peck Prior | Editor |
| Tony Lombardo | Editor |
| Risa Bramon Garcia | Casting |
| John Hughes | Writer |
| Billy Hopkins | Casting |
| David Kelley | Second Assistant Director |
| Manny Perry | Stunt Double |
| John W. Corso | Production Design |
| William H. Brown | Associate Producer |
| Ramey E. Ward | Associate Producer |
| Marilyn Vance | Costume Designer |
| Alan C. Blomquist | Unit Production Manager |
| Raymond Hartwick | Unit Production Manager |
| Tom Udell | Unit Production Manager |
| Thomas J. Mack | First Assistant Director |
| Ron Payne | Music Coordinator |
| Michael Stone | Camera Operator |
| Alex Touyarot | First Assistant Camera |
| Michelle Crenshaw | Second Assistant Camera |
| John Waldo | Second Assistant Camera |
| James R. Alexander | Sound Mixer |
| Greg Agalsoff | Boom Operator |
| Marshall Schlom | Script Supervisor |
| Anne Rapp | Script Supervisor |
| Louis M. Mann | Assistant Art Director |
| Daniel Loren May | Set Decoration |
| Casey Hallenbeck | Leadman |
| Kim S. Hobbs | Lead Set Dresser |
| Thomas M. Jones | Set Dresser |
| Daniel B. Clancy | Set Dresser |
| Jerry Moss | Property Master |
| Amie McCarthy Winn | Props |
| Steven Curtis Husch | Props |
| Daniel J. Lester | Costume Supervisor |
| Ilene Giardini | Costumer |
| Silvio Scarano | Costumer |
| Jacqueline G. Arthur | Costume Assistant |
| Forrest L. Futrell | Second Second Assistant Director |
| Shari Leibowitz | Production Coordinator |
| Mary Nitti | Assistant Production Coordinator |
| Tammy Karabas | Production Secretary |
| Adena Lazan | Accounting Clerk Assistant |
| Ronald W. McLeish | Chief Lighting Technician |
| Robert Swander | Chief Lighting Technician |
| John Swanders | Assistant Chief Lighting Technician |
| Roy A. McLeish | Electrician |
| Mel P. Mack | Electrician |
| Morgan Michael Lewis | Key Grip |
| James O. Oakes | Best Boy Grip |
| Danial Miller | Dolly Grip |
| Mark E. Matthys | Grip |
| Dan McKenzie | Grip |
| Jeff Jarvis | Special Effects Coordinator |
| Danny Cangemi | Special Effects |
| Ben Nye Jr. | Makeup Designer |
| Jamie Sue Weiss | Makeup Artist |
| Dione Taylor | Hairstylist |
| Linda Rizzuto | Additional Hairstylist |
| Jacolyn Baker | Location Manager |
| Gina Lombardo | First Assistant Editor |
| Tim Silano | First Assistant Editor |
| Jerrie Fowler | Assistant Editor |
| John Lafferty | Assistant Editor |
| Ed O'Malley | Assistant Editor |
| Tony Taurus | Assistant Editor |
| Tom Bellfort | Supervising Sound Editor |
| Wylie Stateman | Supervising Sound Editor |
| Stan Gilbert | ADR Supervisor |
| George Fredrick | Sound Editor |
| Scott Martin Gershin | Sound Editor |
| Larry Kemp | Sound Editor |
| Lou Kleinman | Sound Editor |
| Michael Magill | Sound Editor |
| Cindy Marty | Sound Editor |
| Jeff Rosen | Sound Editor |
| Frank Smathers | Sound Editor |
| Bob Beher | Assistant Sound Editor |
| Per Hallberg | Assistant Sound Editor |
| Tom Kramer | Music Editor |
| Jeff Carson | Music Editor |
| Chris Jenkins | Sound Re-Recording Mixer |
| Gary Alexander | Sound Re-Recording Mixer |
| Doug Hemphill | Sound Re-Recording Mixer |
| Jeff Passanante | Construction Coordinator |
| Kenneth J. Gagnon Sr. | Construction Coordinator |
| James M. Davis | Construction Foreman |
| Jacob Zawacki | Construction Foreman |
| Steve Homa | Greensman |
| Armand Paoletti | Transportation Coordinator |
| James Hogan | Transportation Captain |
| Patrick J. Lynn | Transportation Co-Captain |
| John Hardy | Transportation Co-Captain |
| Dean Williams | Still Photographer |
| Joan Eisenberg | Unit Publicist |
| Holly Hudecek | Studio Teacher |
| William Shane Grisco | Animal Coordinator |
| Michael D. Cronin | Set Medic |
| Charles J. Brady Jr. | Craft Service |
| Suzanne Smith | Casting Associate |
| Paul Adler | Casting Associate |
| Donah Bassett | Negative Cutter |
| William H. Brown | Second Unit Director |
| Gregory Lundsgaard | Second Unit Director of Photography |
| Ken Blazer | Stunt Double |
| Bob Elmore | Stunt Double |
| M. James Arnett | Stunt Coordinator |
| Chris Hayes | Camera Operator |
| Miranda Garrison | Choreographer |
