 | Steve Carell als Gru (voice) |
 | Kristen Wiig als Agent Lucy Wilde (voice) |
 | Benjamin Bratt als Eduardo 'El Macho' Pérez (voice) |
 | Miranda Cosgrove als Margo (voice) |
 | Russell Brand als Dr. Nefario (voice) |
 | Ken Jeong als Floyd Eagle-san (voice) |
 | Steve Coogan als Silas Ramsbottom (voice) |
 | Elsie Fisher als Agnes (voice) |
 | Dana Gaier als Edith (voice) |
 | Moisés Arias als Antonio Pérez (voice) |
 | Nasim Pedrad als Jillian (voice) |
 | Kristen Schaal als Shannon (voice) |
 | Pierre Coffin als Kevin / Bob / Stuart / Additional Minions / Evil Minions (voice) |
 | Chris Renaud als Additional Minions / Evil Minions / Italian Waiter (voice) |
 | Nickolai Stoilov als Arctic Lab Guards (voice) |
 | Vanessa Bayer als Flight Attendant (voice) |
 | Ava Acres als Additional Voices (voice) |
 | Lori Alan als Additional Voices (voice) |
 | Jack Angel als Additional Voices (voice) |
 | Eva Bella als Additional Voices (voice) |
 | Georgia Cook als Additional Voices (voice) |
 | John Cygan als Additional Voices (voice) |
 | Debi Derryberry als Additional Voices (voice) |
 | Jess Harnell als Additional Voices (voice) |
 | Danny Mann als Additional Voices (voice) |
 | Mona Marshall als Additional Voices (voice) |
 | Mickie McGowan als Additional Voices (voice) |
 | Mason McNulty als Additional Voices (voice) |
 | Alec Medlock als Additional Voices (voice) |
 | Laraine Newman als Additional Voices (voice) |
 | Jan Rabson als Additional Voices (voice) |
 | Andre Robinson als Additional Voices (voice) |
 | Katie Silverman als Additional Voices (voice) |
 | Casey Simpson als Additional Voices (voice) |
 | Claira Nicole Titman als Additional Voices (voice) |
 | Jim Ward als Additional Voices (voice) |
 | April Winchell als Additional Voices (voice) |
 | Joe Matthews als Additional Voices (voice) |
| Tom Johnson | Sound Re-Recording Mixer |
| Chris Meledandri | Producer |
| Carter Goodrich | Character Designer |
| E.J. Holowicki | Sound Effects Editor |
| Robert Taylor | Associate Producer |
| Dennis Leonard | Supervising Sound Editor |
| Jim Passon | Color Timer |
| Carla Hool | Casting |
| Gregory Perler | Editor |
| Ken Daurio | Screenplay |
| Cinco Paul | Screenplay |
| Nick Glennie-Smith | Conductor |
| Heitor Pereira | Original Music Composer |
| Yarrow Cheney | Production Design |
| Janet Healy | Producer |
| Fabrice Joubert | Animation |
| Pierre Coffin | Director |
| Chris Renaud | Director |
| Chihiro Kameyama | Thanks |
| Gary Rizzo | Sound Re-Recording Mixer |
| David Rosenbaum | Production Manager |
| Brett Hoffman | Script Supervisor |
| Pharrell Williams | Songs |
| Colin Stimpson | Color Designer |
| Eric Guillon | Art Direction |
| Olivier Adam | Set Designer |
| Sergio Casas | Color Designer |
| Christoph Charriton | Set Designer |
| Gregory Georges | Color Designer |
| Clément Griselain | Color Designer |
| Paul Mager | Set Designer |
| Wilbert Plijnaar | Storyboard |
| Loïc Rastout | Set Designer |
| Philippe Tilikete | Prop Maker |
| Roni Pillischer | ADR & Dubbing |
| Paul Tirone | Sound Recordist |
| Cédric Chapeleau | Technical Supervisor |
| Jonathan del Val | Animation |
| Jean Hemez | Supervising Animator |
| Matthew Nealon | Storyboard |
| Dave Cory | First Assistant Editor |
| Bruno Dequier | Animation Director |
| Bjorn Ole Schroeder | ADR Supervisor |
| Sean England | Foley |
| Slamm Andrews | Music Editor |
| Andrew Walton | First Assistant Editor |
| Chris Scarabosio | Sound Designer |
| Chris Scarabosio | Additional Sound Re-Recording Mixer |
| Mac Smith | Sound Effects Editor |
| Jeannine Berger | Post Production Supervisor |
| Mael Gourmelen | Animation |
| Erik Foreman | Foley Editor |
| Julie Adams | Dialect Coach |
| Pierre Leduc | Animation Director |
| Nicolas Valade | Sets & Props Artist |
| Laurent Rossi | Animation |
| Catherine Catie Lee | Lighting Artist |
| Patrick Delage | Animation |
| Yannick Lecoffre | Lighting Artist |
| Julien Soret | Supervising Animator |
| Claire Dodgson | Editor |
| Christopher Barnett | Additional Sound Re-Recording Mixer |
| Jonathan Borland | Sound Effects Editor |
| Kevin Globerman | Sound Recordist |
| Frank Rinella | Foley Editor |
| Ronni Brown | Foley |
| Alan Meyerson | Score Engineer |
| Bruno Chauffard | CG Supervisor |
| Tyler Werrin | Editorial Coordinator |
| Boris Jacq | CG Supervisor |
| Benoit Bargeton | Animation |
| Ladd McIntosh | Orchestrator |
| Alexandre Ronco | Animation |
| Jean-Luc Florinda | Production Supervisor |
| Laurent de la Chapelle | Animation Supervisor |
| Daniel Callaby | Animation |
| Audrey Fobis | Animation |
| Silke Jager | Animation |
| Gilad Carmel | Associate Editor |
| Anthony Voisin | Lighting Artist |
| Jason Hanel | Color Designer |
| Vincent Blanqué | Lighting Artist |
| Cédric Burkarth | Lighting Artist |
| Ephraïm Drouet | Lighting Artist |
| Benoit Fournol | Lighting Artist |
| Pierre Avon | Supervising Animator |
| Nicolas Bauduin | Supervising Animator |
| Elodie Labbe | Lighting Artist |
| François-Xavier Bologna | Supervising Animator |
| Emmanuel Vergne | Supervising Animator |
| Etienne Pêcheux | Supervising Technical Director |
| Eric Garandeau | Thanks |
| Daniel Pool-Kolb | Thanks |
| Agnès Reault | Thanks |
| Igor Primault | Thanks |
| Kevin Bolen | Sound Recordist |
| Julien Frantz | Software Engineer |
| Marc Girou | Software Engineer |
| Thierry Lauthelier | Software Engineer |
| Frédéric Cros | Software Engineer |
| Ludovic Lefève-Gourmelon | Software Engineer |
| Benoit Lepage | Software Engineer |
| Geoff Levner | Software Engineer |
| Baptiste Sansierra | Software Engineer |
| Alexandre Verlhac | Software Engineer |
| Mélissa Faucher | Software Engineer |
| Sébastien Masino | Software Engineer |
| Thomas Métais | Software Engineer |
| Alexandra Skinazi | Sets & Props Supervisor |
| Thibault Collonges | Sets & Props Artist |
| Hortense Goyard | Sets & Props Artist |
| Elodie Hickson | Sets & Props Artist |
| Gilles Roman | Sets & Props Artist |
| Angela Smaldone | Sets & Props Artist |
| Aurélien Hulot | Sets & Props Artist |
| Cyril Thauvain | Sets & Props Artist |
| Franck Clarenc | Sets & Props Artist |
| Grégoire Foret | Sets & Props Artist |
| Jérémie Mamo | Sets & Props Artist |
| Ludovic Ramière | Sets & Props Artist |
| Laura Giardini | Set Dresser |
| Axelle De Cooman | Set Dressing Supervisor |
| Nicolas Brack | Lighting Supervisor |
| Charles Seignolle | Lighting Coordinator |
| Démian Boude | Lighting Artist |
| Florent Cadel | Lighting Artist |
| Jérôme Cordier | Lighting Artist |
| Thomas Dairain | Lighting Artist |
| Bertrand De Becque | Lighting Artist |
| John Hreich | Lighting Artist |
| Romain Silva Macedo | Lighting Artist |
| Mickael Mandonnet | Lighting Artist |
| Jean-Pierrick Muggianu | Lighting Artist |
| Victor Pajot | Lighting Artist |
| Olivier Prigent | Lighting Artist |
| Julien Rocchi | Lighting Artist |
| Arnaud Servouze | Lighting Artist |
| Arnaud Tisseyre | Lighting Artist |
| Christophe Brejon | Lighting Artist |
| Loïc Salmon | Lighting Artist |
| Lionel Cuendet | Master Lighting Artist |
| Sophie Guillois | Master Lighting Artist |
| Thierry Noblet | Master Lighting Artist |
| Max Tourret | Master Lighting Artist |
| Damien Viatte | Master Lighting Artist |
| Selim Draïa | Master Lighting Artist |
| George Hiro Herrmann | Finance |
| Julie Virgile | Finance |
| Céline Le Barbenchon | Editorial Coordinator |
| Julien Badoil | Color Designer |
| Thomas Laffin | Animation Department Coordinator |
| Benjamin Tussiot | Animation |
| Steve Alves | Animation |
| Hichem Arfaoui | Animation |
| Salem Arfaoui | Animation |
| Arnaud Berthier | Animation |
| Cécile Brossette | Animation |
| Antoine Collet | Animation |
| Simon Cuisinier | Animation |
| Luc Dégardin | Animation |
| Christophe Delisle | Animation |
| Axel Digoix | Animation |
| Pierre-François Duhamel | Animation |
| Damien Duprat | Animation |
| Gabriel Gelade | Animation |
| Nicolas Gibut | Animation |
| Jean-Charles Gonin | Animation |
| Adeline Grange | Animation |
| Benoit Guillaumot | Animation |
| Basile Heiderscheid | Animation |
| Sebastien Kunert | Animation |
| Vincent Le Ster | Animation |
| Vincent Lemaire | Animation |
| Alexandre Xiaoguang Li | Animation |
| Adrien Liv | Animation |
| Gaël Matchabelli | Animation |
| Gwénolé Oulc'hen | Animation |
| Yohan Pelladeaud | Animation |
| Yung Pham | Animation |
| Boris Plateau | Animation |
| Patrick Pujalte | Animation |
| Claude Ricros | Animation |
| Ludovic Roz | Animation |
| Gaël Sabourin | Animation |
| Corentin Sacré | Animation |
| Ludovic Savonnière | Animation |
| Damien Zeelen | Animation |
| Guillame Dhont | Animation |
| Guillaume Hérent | Animation |
| Mathieu Ménard | Animation |
| Vincent Devay | Animation |
| Céline Roz-Locatelli | Animation Supervisor |
| Joe Matthews | Musician |
