 | Tom Cruise als Ray Ferrier |
 | Dakota Fanning als Rachel Ferrier |
 | Justin Chatwin als Robbie Ferrier |
 | Miranda Otto als Mary-Ann |
 | Tim Robbins als Harlan Ogilvy |
 | Rick Gonzalez als Vincent |
 | Yul Vazquez als Julio |
 | Lenny Venito als Manny the Mechanic |
 | Lisa Ann Walter als Bartender/Sheryl |
 | Ann Robinson als Grandmother |
 | Gene Barry als Grandfather |
 | David Alan Basche als Tim |
 | Roz Abrams als Herself |
 | Camillia Monet als News Producer |
 | Michael Brownlee als TV Reporter, Osaka |
 | Marlon Young als News Cameraman |
 | John Eddins als News Van Driver |
 | Peter Gerety als Hatch Boss / Load Manager |
 | David Harbour als Dock Worker |
| Miguel Antonio Ferrer als Brazilian Neighbor |
 | January LaVoy als Brazilian Neighbor's Wife |
 | Stephen Gevedon als Neighbor with Lawnmower |
 | Julie White als Woman |
| Marianne Ebert als Hysterical Woman |
 | Rafael Sardina als Mechanic's Assistant |
 | Amy Ryan als Neighbor With Toddler |
 | Ed Vassallo als Intersection Guy |
 | Michael Arthur als Intersection Guy |
 | Danny Hoch als Intersection Guy Cop |
 | Sharrieff Pugh als Man Studying Street |
| Erika LaVonn als Photographer |
 | Christopher Evan Welch als Photographer |
 | John Michael Bolger als Man Holding Woman |
| Omar Jermaine als Man Holding Woman |
 | Robert Cicchini als Guy in Suit |
 | Jim Hanna als Bus Driver |
 | Tracy Howe als Crowd Onlooker |
 | Adam Lazarre-White als Crowd Onlooker |
 | Vito D'Ambrosio als Crowd Onlooker |
| Laura Zoe Quist als Crowd Onlooker |
 | Ana Maria Quintana als Crowd Onlooker |
| Lorelei Llee als Crowd Onlooker |
| Mark Manley als Ferry Worker |
 | John Scurti als Ferry Captain |
 | Becky Ann Baker als Disaster Relief Volunteer |
 | Mariann Mayberry als Mother |
 | Ty Simpkins als 3 Year Old Boy |
 | Jerry Walsh als Smart Guy |
 | Tommy Guiffre als National Guardsman |
 | Daniel Franzese als National Guardsman |
 | Ed Schiff als Older Man |
| Ellen Barry als Woman from Upstate |
 | Amy Hohn als Panicky Woman |
 | Dan Ziskie als Informative Guy |
| David Conley als Ill-Informed Guy |
 | Daniel Eric Gold als Conspiracy Buff |
| Booker T. Washington als Conspiracy Debunker |
 | Maggie Lacey als Upset Mother |
 | Eric Zuckerman als Doomsday Guy |
| Daniel A. Jacobs als Younger Man |
| Asha R. Nanavati als Woman in Crowd |
| Joaquin Perez-Campbell als Young Soldier in Tank |
 | Dendrie Taylor als Well Meaning Mother |
 | James DuMont als Well-Meaning Father |
 | Travis Aaron Wade als Soldier |
| Benny Ciaramello als Soldier |
 | Ricky Luna als Soldier |
 | Columbus Short als Soldier |
 | Kent Faulcon als Soldier |
 | Kevin Collins als Marine Major |
| Terry Thomas als Marine Major |
| Clay Bringhurst als Airforce Pilot |
 | Jorge-Luis Pallo als Army Private |
 | Suanne Spoke als Businesswoman |
 | Kirsten Nelson als Businesswoman |
| Melody Garrett als Older Woman |
 | Lauri Johnson als Older Woman |
 | Takayo Fischer als Older Woman |
 | Shanna Collins als Teenager |
 | Elizabeth Jayne Hong als Teenager |
 | Art Chudabala als Man in Basket |
 | Jeffrey Hutchinson als Man in Basket |
 | Dempsey Pappion als Man in Basket |
 | Chris Todd als Man in Basket |
 | Johnny Kastl als Boston Soldier |
 | Juan Carlos Hernández als Boston Soldier |
| Bruce W. Derdoski Jr. als Boston Soldier |
| John N. Morales als Boston Soldier |
 | Morgan Freeman als Narrator (Voice) |
 | Peter E. Tasciotti als Soldier (uncredited) |
 | David Gere als Survivor (uncredited) |
| James Boss als Refugee (uncredited) |
 | Martin Dew als Looter in Diner (uncredited) |
| Joe Duffy als Refugee fleeing Martians / Ferry passenger (uncredited) |
| Freddie Johnson als Boston Survivor (uncredited) |
 | Anthony Jennings als Amputee (uncredited) |
| Ingrid Johnson als Ray's Neighbor (uncredited) |
| Tanda Kerín als Woman in Crowd (uncredited) |
| Victor Magnusson als Child in Crowd (uncredited) |
| Robert O'Connor als Homeless Patron (uncredited) |
| Miho Nakamura als Passenger (uncredited) |
| Vladislav Kozlov als Survivor |
 | Channing Tatum als Boy in Church (uncredited) |
 | Kyle S. Brown als Marine Rifleman (uncredited) |
| Benjamin Popolukus als Soldier (uncredited) |
| John Williams | Original Music Composer |
| John Williams | Conductor |
| Debra Zane | Casting |
| Jennifer Alessi | Extras Casting |
| Steven Spielberg | Director |
| Kathleen Kennedy | Producer |
| Colin Wilson | Producer |
| Janusz Kamiński | Director of Photography |
| Michael Kahn | Editor |
| Terri Taylor | Casting |
| Rick Carter | Production Design |
| Doug J. Meerdink | Art Direction |
| Joanna Johnston | Costume Design |
| Cari Finken | Special Effects |
| Josh Friedman | Screenplay |
| David Koepp | Screenplay |
| Dennis Muren | Senior Visual Effects Supervisor |
| Andrew Menzies | Art Direction |
| Anne Kuljian | Set Decoration |
| Richard Hymns | Sound Editor |
| Richard Hymns | Supervising Sound Editor |
| Tony Fanning | Supervising Art Director |
| Roy Barnes | Set Designer |
| Paula Wagner | Executive Producer |
| Bruce Paul Barbour | Utility Stunts |
| H.G. Wells | Novel |
| Daniel Sudick | Special Effects Coordinator |
| Vic Armstrong | Stunt Coordinator |
| Vic Armstrong | Second Unit Director |
| Mark De Alessandro | Stunts |
| Randy Thom | Sound Designer |
| Conrad Pope | Orchestrator |
| R.J. Kizer | Supervising ADR Editor |
| David Lucarelli | ADR Engineer |
| Charleen Richards | ADR Mixer |
| Brian Witten | Production Executive |
| Caitlin McKenna | ADR Voice Casting |
| Jennifer Caputo | Stunts |
| Chris Baker | Storyboard Artist |
| Stefan Sonnenfeld | Colorist |
| Casey O'Neill | Stunt Double |
| Sam Seig | First Assistant Editor |
| David Witz | Unit Production Manager |
| Robert Jackson | Boom Operator |
| Shawn Murphy | Scoring Mixer |
| David Blitstein | Special Effects Supervisor |
| Laura Albert | Stunts |
| Gregory Alpert | Production Supervisor |
| Peter Epstein | Stunts |
| James Barron | Carpenter |
| John Cenatiempo | Stunts |
| Kenny Myers | Makeup Artist |
| Norman Newberry | Art Direction |
| Hugo Weng | Dialogue Editor |
| G. A. Aguilar | Stunts |
| Kasra Farahani | Costume Illustrator |
| Gary A. Hecker | Foley |
| Damian Collier | Executive Producer |
| Ron Judkins | Sound Mixer |
| Christian Zimmermann | Standby Painter |
| Adam Somner | First Assistant Director |
| Simon Jayes | Camera Operator |
| David Gere | Stunts |
| Armen Ksajikian | Musician |
| B. J. McDonnell | Additional Grip |
| Donna Maloney | Costume Supervisor |
| Vance Hartwell | Makeup Effects |
| Tannis Vallely | Casting Associate |
| Stephanie Finochio | Stunts |
| Lois Burwell | Makeup Department Head |
| Matthew Gratzner | Visual Effects Supervisor |
| Randy Singer | Foley Mixer |
| Linda Grimes | Makeup Artist |
| Pamela Wise | Costume Supervisor |
| Paul E. Short | Stunts |
| Andy Nelson | Sound Re-Recording Mixer |
| Robert Wojewodski | Assistant Costume Designer |
| Richard King | Sound Designer |
| Richard King | Supervising Sound Editor |
| Michael Magill | Dialogue Editor |
| Colleen Gibbons | Location Manager |
| Ana Maria Quintana | Script Supervisor |
| Hamilton Sterling | Sound Effects Editor |
| Addison Teague | Sound Effects Editor |
| Piero Mura | Sound Effects Editor |
| Scott Getzinger | Assistant Property Master |
| Michael J. Broomberg | Foley |
| Michael J. Broomberg | Foley Artist |
| Timmy Cruz | Camera Operator |
| Doug Harlocker | Property Master |
| Michael W. Mitchell | Sound Designer |
| Pablo Helman | Visual Effects |
| George Billinger III | Camera Operator |
| Judith M. Brown | Studio Teachers |
| Frank Masi | Still Photographer |
| Edward Hirsh | Additional Visual Effects |
| Andrew Cooper | Still Photographer |
| David Devlin | Chief Lighting Technician |
| Maxwell R. Johnson II | Transportation Captain |
| James Wright | Dolby Consultant |
| Bill Almeida | Best Boy Electric |
| Val Drake | Sculptor |
| Mitch Dubin | Camera Operator |
| Kay Michaels | Set Decorating Coordinator |
| Michael Gleason | Visual Effects Editor |
| Anna Behlmer | Sound Re-Recording Mixer |
| Jim Milton | Visual Effects |
| Kathryn Blondell | Hair Department Head |
| Tommy Tancharoen | Transportation Coordinator |
| Candice D. Campos | Production Coordinator |
| Aaron Glascock | Sound Designer |
| Audrey L. Anzures | Key Hair Stylist |
| Jerry DeCarlo | Key Hair Stylist |
| Peter Myles | Music Editor |
| Deborah Wuliger | Unit Publicist |
| Pam Aaron | Set Costumer |
| Christian Beckman | Makeup Effects |
| Laura Graham | ADR Editor |
| David Corral | Greensman |
| Craig Heath | Sound Recordist |
| Edward A. Gutentag | Camera Operator |
| Christian Alzmann | Visual Effects Art Director |
| Chris Gallaher | Makeup Effects |
| Kim Marks | VFX Director of Photography |
| Joel Goldes | Dialect Coach |
| Russell Griffith | Lighting Technician |
| James Bolt | Additional Sound Re-Recording Mixer |
| Michael Babcock | Sound Designer |
| Enrique Bilsland | Mechanical Designer |
| Connie Kennedy | Visual Effects Coordinator |
| Dale E. Grahn | Color Timer |
| Derek Casari | Sound Engineer |
| Cedar Valentine | Art Department Coordinator |
| Jenn Emberly | Animation Supervisor |
| Andrew Bock | First Assistant Sound Editor |
| Brooks P. Guyer | Camera Operator |
| John Crowder | Assistant Location Manager |
| Rick O'Connor | CG Animator |
| Eric Richard Lasko | Second Second Assistant Director |
| Shawn Kelly | Animation |
| Eliza Coleman | Stunts |
| Richard Blankenship | Construction Coordinator |
| Steven Meizler | First Assistant Camera |
| Jamie Grove | Painter |
| Chris Navarro | ADR Recordist |
| Clay Liversidge | Rigging Gaffer |
| Amy Roth | Costume Supervisor |
| Carlos DePalma | Rigging Grip |
| Larry Zanoff | Armorer |
| Katharine Kremp | Hairstylist |
| David Fencl | Armorer |
| Jessica Ripka | Art Department Assistant |
| Terry Atchison | Armorer |
| Edward Karam | Orchestrator |
| Al Goto | Stunts |
| Patrick Crane | First Assistant Editor |
| Randy Dutra | Animation Supervisor |
| Tim Harrington | Animation Supervisor |
| Ryan Church | Creature Design |
| Frank House | Armorer |
| Steve Karnes | Armorer |
| Karl J. Weschta | Armorer |
| Peter Gelfman | Property Master |
| Lee McLaughlin | Still Photographer |
| Linda Folk | ADR Editor |
| Christopher Flick | Foley |
| Jim Richards | Gaffer |
| Dave Samuel | Gaffer |
| James Boniece | Key Rigging Grip |
| John Bullard | Propmaker |
| Marc Gabbana | Concept Artist |
| Cookie Lopez | Dresser |
| Mark David Kersey | Head Greensman |
| Robin Lynn Bonaccorsi | Stunts |
| Brian Lieberz | Production Driver |
| Nicole Callender | Stunts |
| Shawnna Thibodeau | Stunts |
| Michael J. Birnkrant | Picture Car Coordinator |
| Jim Kwiatkowski | First Company Grip |
| Heidi Moneymaker | Stunts |
| Tim L. Pearson | Production Accountant |
| Brian Feola | Construction Foreman |
| Dana Dru Evenson | Stunts |
| Dan Moore | Video Assist Operator |
| Mark George Gillard | Assistant Editor |
| Wayne Petrucelli | Security Coordinator |
| James Clyne | Production Illustrator |
| Harry Lu | Armorer |
| Dane Farwell | Stunts |
| Marshall Richard Krasser | Compositing Supervisor |
| Yogi Allen | Technical Advisor |
| Colin Benoit | Layout |
| Guy Efrat | Location Scout |
| Kendra Levenberg | Craft Service |
| Rich Andrade | Set Dresser |
| Gary Burritt | Negative Cutter |
| Charlie Marroquin | Key Grip |
| Frank Boone | Grip |
| Rob Cunningham | Utility Sound |
| Stephanie Taubert | Rotoscoping Artist |
| Patrick Brennan | Sequence Supervisor |
| Michael Auszura | Assistant Art Director |
| Sandra Scott | Visual Effects Producer |
| Larry J. Richardson | Assistant Chief Lighting Technician |
| Stephen Caldwell | Scenic Artist |
| Steven Carbajal | Location Coordinator |
| Christian J. Hollyer | Camera Loader |
| Owen Hooker | Camera Intern |
| Dan Buckman | Driver |
| Michael Pedraza | Post Production Assistant |
| Stephanie Ito | Post Production Supervisor |
| Justin B. Tolley | Production Intern |
| Sean G. Miller | Security |
| Ian Calip | Set Production Assistant |
| Jason Phillip Johnson | Software Engineer |
| Kathryn Barnhardt | Stand In |
| Robert Allen Jr. | Electrician |
| Colin Campbell | Digital Compositors |
| Annie Ellis | Stunts |
| Deb Dalton | Costume Supervisor |
| Lynn Johnson | Set Medic |
| Craig T. Shordon | Decorator |
| C. Michael Easton | Senior Animator |
| Todd Vaziri | Compositing Artist |
| Paul Candrilli | Best Boy Grip |
| John Mang | Dolly Grip |
| Jan Burgess | Assistant Camera |
| Gerald Ragland | Digital Intermediate Assistant |
| Eugene Paul Lynch | Shop Electric |
| Lindsay MacGowan | Effects Supervisor |
| James D'Damery Jr. | Second Assistant Accountant |
| Vesper Burnett | Extras Casting Assistant |
| Lisa Bojarski | Costumer |
| Roy Augenstein | Special Effects Technician |
| Tom Jordan | Second Assistant Camera |
| Sue Frey | Executive Assistant |
| Joseph C. Pepe | Concept Artist |
| Michael Beaudin | First Assistant Accountant |
| Matthew Sirianni | Assistant Director |
| Monica Barraza | Production Secretary |
| Jerome Zelle | Assistant Craft Service |
| Joan Winters | Graphic Designer |
| Tammy Blackburn | Animal Wrangler |
| Matthew Mason | Key Set Production Assistant |
| Pete Billington | CG Artist |
| Ian Stone | Second Assistant Director |
| Suzanne Fluty | Costume Assistant |
| Linda Redmon | Key Costumer |
| Christine Schultz | Tailor |
| Jane Ferguson | Additional Second Assistant Director |
| Patrick Johnson | Construction Grip |
| Todd MacNicholl | Key Construction Grip |
| Bridget Maria Goodman | VFX Artist |
| Delia Behpour | Visual Effects Production Assistant |
| Szymon Kaczmarek | Camera Production Assistant |
| Steve O'Hallearn | Second Company Grip |
| Abdul-Majeed Moulvi | Casting Assistant |
| Michelle Warble | Wardrobe Assistant |
| Mark Todd Osborne | Additional Colorist |
| Samantha Becker | Post Production Coordinator |
| Joseph Aquino | Location Assistant |
| Maxwell Anderson | Location Production Assistant |
| Emily Nilsen | Additional Production Assistant |
| John Kouromihelakis | Art Department Production Assistant |
| Bill Oaks | Assistant Accountant |
| Philip A. Ramos | Assistant Production Coordinator |
| Dugan Beach | Creature Technical Director |
| Gaby Ortega | Payroll Accountant |
| Jonathan M. Abrams | Production Assistant |
| Steve Christensen | Researcher |
