 | Lyric Ross als Kat Elliot (voice) |
 | Keegan-Michael Key als Wendell (voice) |
 | Jordan Peele als Wild (voice) |
 | Sam Zelaya als Raúl Cocolotl (voice) |
 | James Hong als Father Bests (voice) |
 | Angela Bassett als Sister Helley (voice) |
 | Gabrielle Dennis als Wilma Elliot (voice) |
 | Gary Gatewood als Delroy Elliot (voice) |
 | Igal Naor als Manberg (voice) |
 | Tamara Smart als Siobhan (voice) |
 | Seema Virdi als Sloane (voice) |
 | Ramona Young als Sweetie (voice) |
 | Maxine Peake als Irmgard Klaxon (voice) |
 | David Harewood als Lane Klaxon (voice) |
 | Ving Rhames als Buffalo Belzer (voice) |
 | Michele Mariana als Sister Chinstrap / Sister Daley (voice) |
 | Natalie Martinez als Mariana Cocolotl (voice) |
 | Tantoo Cardinal als Ms. Hunter (voice) |
| Serelle Strickland als Young Kat (voice) |
| Phoebe Lamont als Bearz-A-Bub (voice) |
 | Nick E. Tarabay als Fawzi (voice) |
| Joseph Tran als Dr. Ngo (voice) |
 | Carolyn Crawford als Cassandra / Sukie Jordan (voice) |
| Mandy Hutchings als Governor Bribes (voice) |
| Samantha Fawaz als Female Cop (voice) |
| Henry Selick | Director |
| Henry Selick | Producer |
| Pablo Lobato | Character Designer |
| Jordan Peele | Producer |
| Ellen Goldsmith-Vein | Producer |
| Sarah Serata | Co-Producer |
| Peter Principato | Executive Producer |
| Joel Zadak | Executive Producer |
| Lindsay Williams | Executive Producer |
| Eddie Gamarra | Executive Producer |
| Peter Sorg | Director of Photography |
| Benjamin William Adams | Sculptor |
| Fernando Rosendo | Props |
| Carlos Sotolongo | Dialogue Editor |
| Matt Brumit | Digital Compositor |
| Amanda Colleen Goad | Compositor |
| Michael Milella | Key Grip |
| James WilderHancock | Grip |
| Emily Bender | Music Coordinator |
| Rob Lowry | Music Supervisor |
| Olivier Mouroux | Publicist |
| Robert Anich | Editor |
| Sarah K. Reimers | Editor |
| Bruno Coulais | Original Music Composer |
| Matthew Brooks | Art Direction |
| Jason Kolowski | Art Direction |
| Jason Lajka | Art Direction |
| Tom Proost | Art Direction |
| Peter Vickery | Visual Effects Supervisor |
| Henry Selick | Book |
| Clay McLeod Chapman | Book |
| Henry Selick | Screenplay |
| Jordan Peele | Screenplay |
| Win Rosenfeld | Producer |
| Julie Ragland | Line Producer |
| Kamil Oshundara | Executive Producer |
| Ian Cooper | Executive Producer |
| Amy McLeish | Co-Producer |
| Jenn Fee | Production Manager |
| Melissa St. Onge | First Assistant Director |
| Malcolm Lamont | Animation Supervisor |
| Jeff Riley | Animation Supervisor |
| Mandy Hutchings | Editor |
| Jason Hooper | Editor |
| Paul McEvoy | Other |
| Terri Taylor | Casting |
| Anthony Scott | Lead Animator |
| Suzanne Twining | Lead Animator |
| Matias Liebrecht | Lead Animator |
| Michael Granberry | Lead Animator |
| Joe Heinen | Animation |
| Ian Boone Timothy | Animation |
| Porter Young | Animation |
| Clay McLeod Chapman | Associate Producer |
| Maddie Loftesnes | Production Coordinator |
| Kristina Soderquist | Production Accountant |
| Sarah Domeier Lindo | Casting Associate |
| Ally Conover | Casting Associate |
| Nadine Patterson | Lead Costumer |
| Craig Atkinson | Rigging Supervisor |
| Jerry Svoboda | Rigging Supervisor |
| Victoria Cloyes | Lead Set Dresser |
| Trevor Cable | Post Production Supervisor |
| Seema Virdi | Storyboard Artist |
| David Vandervoort | Storyboard Artist |
| Cécile Carre | Storyboard Artist |
| Mike Cachuela | Storyboard Artist |
| Kevin Harkey | Storyboard Artist |
| David William Trumble | Storyboard Artist |
| Yuna Cheong | Storyboard Artist |
| Jordan Tremayne | Gaffer |
| Helder K. Sun | Additional Director of Photography |
| Heather Abels | Digital Supervisor |
| Justin Graham | Roto Supervisor |
| Oliver Arnold | CG Supervisor |
| Ozen Sayidof | Visual Effects Producer |
| Sonja Burchard | Compositing Supervisor |
| Jeremy Bowker | Supervising Sound Editor |
| Jeremy Bowker | Sound Designer |
| Randy Thom | Sound Designer |
| Lora Hirschberg | Sound Re-Recording Mixer |
| Danielle Dupre | Sound Re-Recording Mixer |
| Joel Raabe | Sound Effects Editor |
| Luke Dunn Gielmuda | Sound Effects Editor |
| Lucas Miller | Sound Effects Editor |
| E. Larry Oatfield | Foley Supervisor |
| Jordan Myers | Foley Editor |
| Jana Vance | Foley Artist |
| Ronni Brown | Foley Artist |
| Richard Duarte | Foley Mixer |
| Anne Coulais | Music Producer |
| Andrew Vernon | Music Editor |
| Mark Sussman | ADR & Dubbing |
| Patty Connolly | ADR & Dubbing |
| Erin Myles | ADR & Dubbing |
| Andrew Morgado | ADR & Dubbing |
| Arthur Ortiz | ADR & Dubbing |
| Cassandra Lee Morris | ADR & Dubbing |
| Amad Jackson | ADR & Dubbing |
| ViviAnn Yee | ADR & Dubbing |
| Mark Musumeci | In Memory Of |
