 | Gael García Bernal als Jack Russell |
 | Laura Donnelly als Elsa Bloodstone |
 | Harriet Sansom Harris als Verussa Bloodstone |
 | Kirk R. Thatcher als Jovan |
 | Eugenie Bondurant als Azarel |
 | Leonardo Nam als Liorn |
 | Daniel J. Watts als Barasso |
 | Al Hamacher als Billy Swan |
 | Carey Jones als Ted (Man-Thing) |
 | David Silverman als The Flaming Tuba |
 | Rick D. Wasserman als Narrator (voice) |
 | Richard Dixon als Ulysses Bloodstone (voice) |
 | Jeffrey Ford als Additional Man-Thing Vocalizations (voice) |
 | Erik Beck als Puppeteer |
| Kevin Feige | Executive Producer |
| Michael Giacchino | Director |
| Zoë White | Director of Photography |
| Victoria Alonso | Executive Producer |
| Louis D'Esposito | Executive Producer |
| Sarah Halley Finn | Casting |
| Gerry Conway | Characters |
| Mike Ploog | Characters |
| Michael Giacchino | Original Music Composer |
| Brian Gay | Co-Executive Producer |
| Trevor Waterson | Co-Executive Producer |
| Stephen Broussard | Executive Producer |
| Brad Winderbaum | Executive Producer |
| Jeffrey Ford | Editor |
| Maya Shimoguchi | Production Design |
| Mayes C. Rubeo | Costume Design |
| Joe Farrell | Visual Effects Supervisor |
| Peter Cameron | Teleplay |
| Heather Quinn | Teleplay |
| Heather Quinn | Story |
| Leeann Stonebreaker | Producer |
| Leeann Stonebreaker | Unit Production Manager |
| Janell Sammelman | First Assistant Director |
| Angie Read | Second Assistant Director |
| Lauren Miyake | Visual Effects Producer |
| Dave Jordan | Music Supervisor |
| Krista Husar | Casting |
| Paul Jennings | Second Unit Director |
| Heather Quinn | Co-Producer |
| Peter Cameron | Consulting Producer |
| Josh Gold | Supervising Sound Editor |
| Juan Peralta | Sound Re-Recording Mixer |
| Michael Semanick | Sound Re-Recording Mixer |
| Evan Jacobs | Stereoscopic Supervisor |
| Sarah Halley Finn | Consulting Producer |
| Anele Onyekwere | Other |
| Anele Onyekwere | Supervising Music Editor |
| Ian Joyner | Visual Development |
| Casey O'Neill | Stunt Coordinator |
| Luis Valladares | Stunt Double |
| Christopher Gonzalez | Stunt Double |
| Sarah Irwin | Stunt Double |
| Sabreena Candreva | Stunt Double |
| Dan B. Norris | Stunt Double |
| Jess Durham | Stunt Double |
| Kawui Joa | Stunt Double |
| Morgan Chislett | Stand In |
| Perren Leatherwood | Stand In |
| Marquis Magwood | Stand In |
| Jessica Lee | Stand In |
| Federico Berte | Stunts |
| Corey Diamond | Stunts |
| Cory Dunson | Stunts |
| Califf Guzman | Stunts |
| Tim James | Stunts |
| Juliene Joyner | Stunts |
| Alex Lapeyrolerie | Stunts |
| Brandy Lewis | Stunts |
| CJ Padera | Stunts |
| Devin Regan | Stunts |
| Ronnie Shalvis | Stunts |
| David Conk | Fight Choreographer |
| Roy Thomas | Characters |
| Jean Thomas | Characters |
| Dan Abnett | Thanks |
| Pat Boyette | Thanks |
| Stuart Immonen | Thanks |
| Andy Lanning | Thanks |
| Michael Lopez | Thanks |
| Gray Morrow | Thanks |
| Sonny Trinidad | Thanks |
| Mike Vosburg | Thanks |
| John Warner | Thanks |
| Brad Bird | Thanks |
| Bryan Burk | Thanks |
| Anthony Giacchino | Thanks |
| Nina A. White | Set Dresser |
| Lauren Rosenbloom | Art Direction |
| Tristan Mathews | Post Production Supervisor |
| Glenn Cote | VFX Editor |
| Daniel Young | Visual Effects Coordinator |
| Hank Kilgore | Visual Effects Coordinator |
| Daniel Sudick | Special Effects Supervisor |
| Marc Banich | Special Effects Coordinator |
| Missy Parker | Set Decoration |
| Carey Jones | Makeup Effects Designer |
| Ian MacGregor | Location Manager |
| Donna O'Neal | Costume Supervisor |
| Crystal Broedel | Hair Department Head |
| Ellen Arden | Makeup Department Head |
| Sonya Riviere | Key Hair Stylist |
| Jessica Craig | Key Makeup Artist |
| John Tarro | Hairstylist |
| Katelyn Barton | Makeup Artist |
| Sabrina Wilson | Makeup Artist |
| Josh Gold | Sound Designer |
| Kevin R. Wright | Other |
| Kyle Shariff Austin | Stunt Double |
