 | Andy García als Michael Green |
 | Meg Ryan als Alice Green |
 | Tina Majorino als Jessica Green |
 | Philip Seymour Hoffman als Gary |
 | Lauren Tom als Amy |
 | Mae Whitman als Casey Green |
 | Ellen Burstyn als Emily |
 | Eugene Roche als Walter |
 | Gail Strickland als Pam |
 | Steven Brill als Madras Tie Guy |
 | Susanna Thompson als Janet |
 | Erinn Canavan als Shannon |
 | LaTanya Richardson Jackson als Dr. Gina Mendez |
| Bari K. Willerford als Malcolm |
 | James Jude Courtney als Earl |
| Jacques De Groot als Guy in the Back |
| Anne Ohliger als Jess - 4 Yrs. Old |
| Tony Montero als Bartender |
 | Cynthia Mace als De-tox Nurse |
| Jennie Yee als Vu |
 | William Frankfather als Al-anon Leader |
 | Ellen Geer als Woman at Al-Anon |
| Angelina Fiordellisi als Joanna |
| Elizabeth Lang als AA Woman |
| Syd Field als Patient #1 |
| Peer Ebbighausen als Patient #2 |
| Ronald Bass als AA Man #1 |
 | Joe Drago als AA Man #2 |
| Andrew Magarian als AA Man #3 |
| Amy Treese als AA Woman #2 |
 | Brandis Kemp als AA Woman #3 |
| Judith Friend als AA Woman #4 |
| Deana Kobrynski als AA Woman #5 |
 | Rico E. Anderson als Barfly (uncredited) |
| Lena Banks als Nurse (uncredited) |
 | Richard Bradford als Angry Man Watching TV (uncredited) |
 | Al Franken als Co-Pilot (uncredited) |
 | Craig Richards als Patient #3 (uncredited) |
 | Reed Rudy als Angry Guy (uncredited) |
| Joseph Quinn Simpkins als Barfly (uncredited) |
| Zbigniew Preisner | Original Music Composer |
| Amanda Mackey | Casting |
| Cathy Sandrich Gelfond | Casting |
| Kara Lindstrom | Set Decoration |
| Ronald Bass | Screenplay |
| Ronald Bass | Executive Producer |
| Leonard Engelman | Makeup Artist |
| Robert Deschaine | ADR Mixer |
| Denise Horta | ADR Editor |
| Jon Avnet | Producer |
| Garth Craven | Editor |
| Stuart Wurtzel | Production Design |
| Linda M. Bass | Costume Design |
| Rick Sharp | Makeup Artist |
| Michael St. Hilaire | Camera Operator |
| Steve Saklad | Art Direction |
| Luis Mandoki | Director |
| Lajos Koltai | Director of Photography |
| Steve Danton | First Assistant Director |
| Jordan Kerner | Producer |
| Al Franken | Screenplay |
| Al Franken | Executive Producer |
| Simon Maslow | Executive Producer |
| C. Tad Devlin | Production Manager |
| C. Tad Devlin | Co-Producer |
| Juno J. Ellis | ADR Supervisor |
| Gary Wright | Sound Editor |
| Joseph F. Brennan | Boom Operator |
| Richard Kite | Cableman |
| Dean A. Zupancic | Sound Re-Recording Mixer |
| Colleen Callaghan | Hairstylist |
| Erik Cord | Stunts |
| Barbara Harris | ADR Voice Casting |
| Salli Newman | Associate Producer |
| Fred Burke | Foley Editor |
| Andrea Mae Fenton | Set Dressing Buyer |
| Eddie Lee Voelker | Transportation Coordinator |
| Steven M. Levine | Property Master |
| Rick Ash | Sound Re-Recording Mixer |
| Jeffrey W. Petersen | Electrician |
| Cynthia Upstill | Script Supervisor |
| Karen Spangenberg | Sound Editor |
| George Watters II | Supervising Sound Editor |
| Stan Tropp | Set Designer |
| Gary A. Krakoff | Construction Coordinator |
| Samuel Craven | Additional Editor |
| Mickey Gilbert | Stunt Coordinator |
| Nancy Jane King | Production Coordinator |
| Midge Costin | Sound Editor |
| David C. Potter | Leadman |
| Robin Citrin | Location Manager |
| Frank R. Jimenez Jr. | Electrician |
| Peter Sorel | Still Photographer |
| Robert Jason | Chief Lighting Technician |
| Teri E. Dorman | Sound Editor |
| R.J. Palmer | Sound Editor |
| F. Hudson Miller | Sound Editor |
| Thomas Causey | Sound Mixer |
| KG Ramsey | Hairstylist |
| Beth Bergeron | ADR Editor |
| Victoria Martin | Foley Editor |
| Laura M. Grody | Assistant Editor |
| Roy Prendergast | Supervising Music Editor |
| Herb Ault | Key Grip |
| Troy Gilbert | Stunts |
| Diane Crooke | Wardrobe Supervisor |
| Maria R. Kelly | Stunts |
| Gloria Kaiser | Color Timer |
| Ken Nishino | First Assistant Camera |
| Jim Likowski | Foley Editor |
| Kathryn Camp | Assistant Editor |
| Steven J. Mikolas | Video Assist Operator |
| Miranda Garrison | Choreographer |
| Larry McCarron | Grip |
| R. Scott Judge | Dolly Grip |
| David Gertz | Foley Mixer |
| Dennis Seawright | Second Assistant Camera |
| Theresa Repola Mohammed | Negative Cutter |
| Lori Koravos | Production Accountant |
| James Robinson II | Assistant Property Master |
| Dustin Ault | Grip |
| Susan Merzbach | Co-Producer |
| Rod Robertson | Best Boy Electric |
| Vincent Mata | Camera Loader |
| Gail Just | Key Costumer |
| Thomas R. Ward | Special Effects Coordinator |
| Shery Blanc | Second Second Assistant Director |
| Kenneth E. King | Best Boy Grip |
| Russ St. John | Key Rigging Grip |
| Daniel Craven | First Assistant Editor |
| Randy Lewis | Rigging Gaffer |
| Bruce Carter | Second Assistant Director |
| Marcus Robertson | Electrician |
| John W. Brumshagen | Electrician |
| David Morrison | Grip |
| Quirina L. Munoz | Set Costumer |
