 | Jessica Chastain als Catherine Weldon |
 | Michael Greyeyes als Sitting Bull |
 | Sam Rockwell als Silas Groves |
 | Ciarán Hinds als James McLaughlin |
 | Chaske Spencer als Chaska |
 | Bill Camp als General Crook |
 | Willy RunsAbove als Chief Black Bear |
 | Louisa Krause als Loretta |
 | Robert Mirabal als Only Man |
| Monika Crowfoot als Seen By The Nation |
 | David Midthunder als Shell King |
| Rulan Tangen als Susan McLaughlin |
| Robert Moreno Sr. als Thunder |
| Ben Ziegler als Attacker in Cannonball |
 | Boots Southerland als Cab Driver NY |
| Ben Black Bear als Chief |
 | Rachel Singer als Dry Goods Assistant |
| Andersen Kee als Indian Policeman |
| Cosme Duarte als Indian Policeman |
| Rod Rondeaux als Indian Robber |
 | Luce Rains als Old Man at Train Station |
| Debbie Black Lance als Old Sioux Woman |
| Makayah Starley Crowfoot als Sioux Child |
 | DezBaa' als Sioux Woman at Ration Day |
| Lyle Sandoval als Tracker |
 | Jacob Browne als Waiter in Dining Car |
| Kindall Charters als Waiter in Sleeping Car |
| Susan Conklin als Woman in Cannonball |
 | Brenda Wehle als Anna Maria Valentine (uncredited) |
| David Hight als Cavalry Lt. (uncredited) |
 | Josh Outzen als Cavalry Soldier (uncredited) |
| Lyle DeRose als Cavalry Soldier (uncredited) |
| Rip Lowe als Cavalry Soldier (uncredited) |
| Philip David Pickard als Colonel (uncredited) |
| Rodrigo Tactaquin als Ghost Dancer (uncredited) |
 | Manny Greenfield als Government Official (uncredited) |
| Rick Tadra als Government Offical (uncredited) |
 | Michael Nouri als Karl Valentine (uncredited) |
 | Claire Weinstein als Native Woman (uncredited) |
 | Andrea Good als Native Villager (uncredited) |
| Denita Wolf als Townsperson (uncredited) |
 | Richard Beal als Townsperson (uncredited) |
| Stephen Conn als Townsperson (uncredited) |
| Tami Nichols Reilly als Townsperson (uncredited) |
| Susanna White | Director |
| Andrea Calderwood | Producer |
| Erika Olde | Producer |
| Marshall Herskovitz | Producer |
| Richard Solomon | Producer |
| Susan Kirr | Executive Producer |
| Lucia Zucchetti | Editor |
| Edward Zwick | Producer |
| Steven Knight | Screenplay |
| Norman Merry | Executive Producer |
| Rory Aitken | Executive Producer |
| Peter Hampden | Executive Producer |
| Lisa Wolofsky | Executive Producer |
| Matis Rei | Sound Designer |
| Steven Rosenblum | Editor |
| Mike Eley | Director of Photography |
| Geoffrey Kirkland | Production Design |
| Billy W. Ray | Art Direction |
| Wilhelm Pfau | Set Decoration |
| Stephanie Collie | Costume Design |
| Katie Douthit | Makeup Artist |
| Linda Dowds | Makeup Department Head |
| Scott Christopher Clark | Set Dresser |
| Kevin Duran | Set Dresser |
| Rachel Lively | Set Dresser |
| Brooke Peters | Set Designer |
| Chris Reisz | Set Dresser |
| Joshua Swanson | Set Dresser |
| Bayard Carey | Production Sound Mixer |
| Robert Farr | Sound Re-Recording Mixer |
| Brian Gilligan | Sound Effects Editor |
| Stephen Griffiths | Supervising Sound Editor |
| Andy Shelley | Supervising Sound Editor |
| Paul Driver | Visual Effects Producer |
| Sheila Wickens | Visual Effects Supervisor |
| Brian Barela | Set Costumer |
| Michelle Kelly | Set Costumer |
| Kim Trujillo | Set Costumer |
| Barcie Waite | Costume Supervisor |
| George Fenton | Original Music Composer |
