 | Al Pacino als Dr. Jack Kevorkian |
 | Danny Huston als Geoffrey Fieger |
 | Susan Sarandon als Janet Good |
 | John Goodman als Neal Nicol |
 | Brenda Vaccaro als Margo Janus |
 | Eric Lange als John Skrzynski |
 | James Urbaniak als Jack Lessenberry |
 | Rutanya Alda als Vendor |
 | Delaney Williams als Detective #1 |
 | Danielle McKee als Dorothy Lessenberry |
 | Adam Driver als Glen Stetson |
 | Deirdre O'Connell als Linda |
 | Todd Susman als Stan Levy |
 | Jennifer Mudge als Female Reporter |
 | Jeremy Bobb als David Rivlin |
 | Henny Russell als Oakhill Spokesperson |
 | Henry Strozier als Oakhill Doctor |
| Sandra Seacat als Janet Adkins |
 | Neil Brooks Cunningham als Rod Adkins |
 | David Wilson Barnes als David Gorcyca |
 | Cotter Smith als Dick Thompson |
 | John Rue als Ray Good |
 | Allen Lewis Rickman als Dr. Dragovic |
 | Kris Eivers als Deputy |
 | Richard Council als Judge David Breck |
 | Jason Babinsky als Detective |
 | Teresa Yenque als Isabel Correa |
 | Jamie Tirelli als Trino Correa |
| John Henry Cox als Mr. Kinsey |
 | Ana Reeder als Lynn Mills |
| Jonathan Teague Cook als Hugh Gale |
 | Tom Kemp als Carl Marlinga |
 | Jordan Lage als Beaumont Doctor |
 | Mason Pettit als Construction Worker |
 | Daryl Edwards als Judge Jackson |
 | Meghan Rafferty als Female Reporter |
 | Deborah Hedwall als Melody Youk |
 | Rondi Reed als Judge Cooper |
 | Adam Mucci als Dave Gorosh |
| Bill Edwards als On-the-Street Interviewee |
 | Kevin Cannon als Defendant (uncredited) |
| Peter Conboy als Oakland County Deputy (uncredited) |
| John Farrer als Hemlock Society Member (uncredited) |
| Renee Fishman als Stenographer (uncredited) |
| Jacqueline Forton als Protester (uncredited) |
| Rennel Turner als Protester (uncredited) |
| Moe Hindi als Paparazzi Photographer (uncredited) |
| Kevin Janaway als Celebrity Party-Goer (uncredited) |
| Joseph John Justin als Inmate (uncredited) |
| Vivian Kalinov als Woman with Dodge Ram Charger (uncredited) |
 | Frosty Lawson als Background with Car (uncredited) |
| Addison LeMay als Reporter (uncredited) |
| Bill Lumbert als Supporter (uncredited) |
| Dwayne Roszkowski als Gentleman at Courthouse (uncredited) |
 | Bill Walters als Michigan Inmate (uncredited) |
| Barry Levinson | Executive Producer |
| Glenn Rigberg | Executive Producer |
| Barry Levinson | Director |
| Tom Fontana | Executive Producer |
| Adam Mazer | Writer |
| Drew Gallagher | Associate Producer |
| Steve Lee Jones | Executive Producer |
| Lydia Dean Pilcher | Executive Producer |
| Scott Ferguson | Producer |
| Deanna Leslie | Assistant Director |
| John Bair | Visual Effects Supervisor |
| Abbot Genser | Still Photographer |
| Meg Schrock | Electrician |
| Cydney Cornell | Hairstylist |
| John J. Ciccimarro | Carpenter |
| Pierre Rovira | Construction Coordinator |
| Matt Vogel | Special Effects |
| Ryan Collison | Foley |
| Paul Urmson | Supervising Sound Editor |
| Jim Dickson | Grip |
| Aaron Yanes | Editor |
| Rita Ryack | Costume Design |
| Susan Reilly LeHane | Makeup Artist |
| Michael Kall | Construction Foreman |
| Robert M. Andres | Grip |
| John Caglione Jr. | Makeup Artist |
| Natasha Ladek | Wigmaker |
| Charles Libin | Camera Operator |
| Joseph Whitmeyer | Key Hair Stylist |
| Scott Ferguson | Unit Production Manager |
| Eric J. Robertson | Visual Effects |
| Marcelo Zarvos | Original Music Composer |
| Mark Ricker | Production Design |
| Joelle Troisi | Makeup Artist |
| Timothy Bird | Assistant Director |
| Ellen Chenoweth | Casting |
| Colleen Callaghan | Hair Department Head |
| Wyatt Sprague | Sound Effects Editor |
| Joe Mancini | Stunts |
| John Wendling | Electrician |
| Vivian Connolly | Visual Effects Producer |
| Doug Cordonier | Grip |
| Douglas Pellegrino | Additional Camera |
| Kymbra Callaghan | Makeup Department Head |
| Bradley Schmidt | Assistant Art Director |
| Dominick Tavella | Sound Re-Recording Mixer |
| Connie Brink | Special Effects Coordinator |
| Jim McCullagh | Gaffer |
| Dorothy J. Pearl | Makeup Department Head |
| Dave McAllister | Grip |
| Christos Moisides | Additional Photography |
| Craig Striano | Grip |
| Amy Fritz | Art Direction |
| Annemarie Bradley | Hairstylist |
| Eigil Bryld | Director of Photography |
| Rena DeAngelo | Set Decoration |
| Aaron Raff | Visual Effects |
| Richie Roefaro | Digital Intermediate |
| Amelia Rasche McCarthy | Casting Associate |
| David Rumble | Location Scout |
| Mark Baechle | Orchestrator |
| Barbara Jean Kearney | Digital Intermediate |
| Julie Adams | Dialect Coach |
| Jennifer Dunnington | Music Editor |
| Tom Leavey | Transportation Captain |
| Eric Klein | Location Scout |
| Chris-Teena Constas | Location Manager |
| Jessica Lichtner | Script Supervisor |
| Evyen Klean | Music Supervisor |
| Sonny Kompanek | Orchestrator |
| Dave Ginsberg | Location Scout |
| Jess Platt | Dialect Coach |
| Kate Abernathy | Assistant Editor |
| Derek Yip | Production Accountant |
| James D. Lee | Location Manager |
| Robin Day | Hairstylist |
| Matthias Gohl | Music Score Producer |
| Jac Rubenstein | Dialogue Editor |
| Rick Chefalas | First Assistant Sound Editor |
| Igor Nikolic | Foley Editor |
| Ruth Hernandez | Supervising ADR Editor |
| Wade Barnett | ADR Recordist |
| Dana Bloder | Digital Intermediate Producer |
| Chris Fogel | Scoring Mixer |
| Lawrence Zipf | Apprentice Sound Editor |
| Brett Rothfeld | ADR Recordist |
| Frank Stettner | Sound Mixer |
| Vinny Mazzarella | Property Master |
| Michael Miller | ADR Mixer |
| Tim Stipan | Digital Intermediate Colorist |
| Donald Sylvester | ADR Editor |
| Jay Peck | Foley Artist |
