 | Jesse Eisenberg als Columbus |
 | Woody Harrelson als Tallahassee |
 | Emma Stone als Wichita |
 | Abigail Breslin als Little Rock |
 | Amber Heard als 406 |
 | Bill Murray als Bill Murray |
 | Derek Graf als Clown Zombie |
 | Elle Alexander als Zombie Meter Maid (uncredited) |
 | Melanie Booth als Hippie Girl (uncredited) |
 | Chris Burns als Bicycle Zombie (uncredited) |
 | Blaise Corrigan als Groom (uncredited) |
 | Sydnie Dawson als Princess Zombie (uncredited) |
 | Justin Price als Sprint Zombie (uncredited) |
| Christina Klein als Zombie (uncredited) |
 | Amir Kovacs als Zombie (uncredited) |
 | Shaun Michael Lynch als Cardio Zombie (uncredited) |
 | Lynn McArthur als Girl on Cell Phone (uncredited) |
| Michelle Sebek als Businesswoman Zombie (uncredited) |
| Victory Van Tuyl als Bubby & Pee Paw's Granddaughter (uncredited) |
 | Mike White als Gas Station Attendant (uncredited) |
| Cesar Aguirre als Customer at the Pump (uncredited) |
 | Daniel Burnley als Frightened Pedestrian (uncredited) |
| Ernest Dancy als Businessman Zombie (uncredited) |
| Jon Gould als Pedestrian in Decatur (uncredited) |
 | Travis Grant als Amusement Park Zombie (uncredited) |
 | Robert Hatch als Yuppie Zombie (uncredited) |
| Jeh Howell als Zombie (uncredited) |
| Amir R. Khan als Point-Blank Zombie (uncredited) |
 | Suzanne LaChasse als Zombie (uncredited) |
| Kurt McNew als Amusement Park Zombie (uncredited) |
| Stephen Prouty als Punched in Face Zombie (uncredited) |
 | Ming Qiu als Achilles Businesswoman (uncredited) |
 | Rhett Reese als Tuxedo Guy with AK-47 (uncredited) |
| April Rich als Hot Mom (uncredited) |
 | Cody Rowlett als Panicked Pedestrian (uncredited) |
| Joan Schuermeyer als Cynthia Knickerbocker (uncredited) |
| Brian Stretch als DC Zombie (uncredited) |
| Sonya Thompson als Lunchroom Lady Zombie (uncredited) |
| Clay Walker als Mechanic (uncredited) |
| Steve Warren als Metro Station Zombie (uncredited) |
| Travis Young als Grocery Store Zombie (uncredited) |
| Rhett Reese | Writer |
| Ryan Kavanaugh | Executive Producer |
| Rhett Reese | Executive Producer |
| Paul Wernick | Executive Producer |
| Gavin Polone | Producer |
| Ezra Swerdlow | Executive Producer |
| Ruben Fleischer | Director |
| Paul Wernick | Writer |
| Michael Bonvillain | Director of Photography |
| Kami Asgar | Supervising Sound Editor |
| T. Ryan Mooney | Stunt Double |
| Magali Guidasci | Costume Design |
| André Freitas | Special Effects Makeup Artist |
| Paul Linden | Visual Effects Supervisor |
| Kimberly Shannon Murphy | Stunt Double |
| Elle Alexander | Stunts |
| Austin Gorg | Art Direction |
| Maher Ahmad | Production Design |
| Cal Johnson | Stunt Driver |
| Bobby Beckles | Stunts |
| Brent Bernhard | Stunts |
| Lacy Parish | Stunt Double |
| G. A. Aguilar | Stunt Coordinator |
| Gene Serdena | Set Decoration |
| Donna Martin | Makeup Artist |
| Kacie Borrowman | Stunt Double |
| Gus Williams | Stunts |
| John Papsidera | Casting |
| Peter Amundson | Editor |
| Alan Baumgarten | Editor |
| Sarah Mays | Makeup Department Head |
| Rachel Kick | Makeup Artist |
| Susan Antonelli | Set Costumer |
| Barnaby Smith | Set Costumer |
| Anita Cannella | Foley Artist |
| Rich Crescenti | ADR Recordist |
| Michael Dressel | Foley Supervisor |
| Kim Drummond | ADR Editor |
| Mary H. Ellis | Sound Mixer |
| Vincent Guisetti | Foley Artist |
| Jeff Gross | Foley Mixer |
| Scott G.G. Haller | Dialogue Editor |
| Larry Hopkins | Sound Mixer |
| Pamela Kahn | Foley Artist |
| Amy Kane | Foley Artist |
| Tateum Kohut | Sound Re-Recording Mixer |
| Mark Larry | Sound Effects Editor |
| Herwig Maurer | Sound Effects Editor |
| Sean McCormack | Supervising Sound Editor |
| Greg Orloff | Sound Re-Recording Mixer |
| Drew Ponder | Boom Operator |
| Eryne Prine | Sound Editor |
| Jacob Riehle | Dialogue Editor |
| Will Riley | Sound Editor |
| Kyle Rochlin | Foley Mixer |
| R. Kevin Clarke | Visual Effects |
| Stéphan Kosinski | Visual Effects Supervisor |
| Kurt McKeever | VFX Artist |
| Jesse Morrow | VFX Artist |
| Doug Spilatro | Visual Effects |
| Mark Keever | Set Dresser |
| Ky Hoang Nguyen | Set Dresser |
| Meegan E. Godfrey | Stunts |
| Melissa Yonkey | Hair Department Head |
| Caroline Vexler | Stunts |
| John Cenatiempo | Stunts |
| Chris Cenatiempo | Stunts |
| Jill Brown | Stunt Coordinator |
| Luci Romberg | Stunt Double |
| Samantha MacIvor | Stunts |
| G. A. Aguilar | Second Unit Director |
| Tim Trella | Stunts |
| Peter Epstein | Stunts |
| Nicole Callender | Stunts |
| Lisa Hoyle | Stunts |
| David Sardy | Original Music Composer |
