 | Kevin James als Griffin Keyes |
 | Rosario Dawson als Kate |
 | Leslie Bibb als Stephanie |
 | Joe Rogan als Gale |
 | Nat Faxon als Dave |
 | Ken Jeong als Venom |
 | Steffiana De La Cruz als Robin |
 | Thomas Gottschalk als Jurgen |
 | Donnie Wahlberg als Shane |
 | Brandon Keener als Nimer |
 | Tom Woodruff Jr. als Bernie the Gorilla |
 | Nick Bakay als Franky |
 | Jackie Sandler als TGIF Waitress |
 | Nicholas Turturro als Manny |
 | Robin Bakay als Rebecca |
 | Gary Valentine als Pizza Guy |
| Tanner Blaze als Little Boy at Zoo |
| Tim Gage als Bike Guy |
| Gino Falsetto als Valet |
| Etienne Deneault als Acrobat |
 | Katrina Begin als TGIF Secretary |
 | Matthew R. Staley als Glenn |
| Michael Burton als Car Customer |
| Todd Zeile als High Roller |
| Mookie Barker als Grandfather |
| Tara Giordano-Dean als Shana |
| Daniel Guire als Salesman |
| Mark DellaGrotte als Salesman |
| Ellen Colton als Shane's Mother |
| Barry Bernardi als Cab Driver |
| Juston McKinney als Upscale Restaurant Manager |
 | Nick Nolte als Bernie the Gorilla (voice) |
 | Adam Sandler als Donald the Monkey (voice) |
 | Sylvester Stallone als Joe the Lion (voice) |
 | Cher als Janet the Lioness (voice) |
 | Judd Apatow als Barry the Elephant (voice) |
 | Jon Favreau als Jerome the Bear (voice) |
 | Faizon Love als Bruce the Bear (voice) |
 | Maya Rudolph als Mollie the Giraffe (voice) |
 | Bas Rutten als Sebastian the Wolf (voice) |
 | Don Rickles als Frog (voice) |
 | Jim Breuer als Crow (voice) |
 | Richie Minervini als Ostrich (voice) |
| Garon Michael als Bernie the Gorilla |
 | Dan Marshall als Zoo Visitor (uncredited) |
 | Crystal the Monkey als Donald the Monkey (uncredited) |
 | Bart the Bear II als Jerome the Bear |
| Frank Coraci | Director |
| Nick Bakay | Screenplay |
| Kevin James | Screenplay |
| Allen Hall | Special Effects Coordinator |
| Jay Scherick | Screenplay |
| Jay Scherick | Story |
| David Ronn | Screenplay |
| David Ronn | Story |
| Rock Reuben | Screenplay |
| Walt Becker | Producer |
| Todd Garner | Producer |
| Jack Giarraputo | Producer |
| Kevin James | Producer |
| Adam Sandler | Producer |
| Rupert Gregson-Williams | Original Music Composer |
| Michael Barrett | Director of Photography |
| Scott Hill | Editor |
| Kirk M. Petruccelli | Production Design |
| Mona May | Costume Design |
| Corina C. Duran-Rabichuk | Makeup Department Head |
| Pierce Austin | Hair Department Head |
| Hilton Rosemarin | Set Decoration |
| Domenic Silvestri | Art Direction |
| Scott Zuber | Art Direction |
| Barry Bernardi | Executive Producer |
| Jeff Sussman | Executive Producer |
| Charles Newirth | Executive Producer |
| Jennifer Eatz | Executive Producer |
| Aimee Keen | Co-Producer |
| Kim Davis-Wagner | Casting |
| Justine Arteta | Casting |
| Peter G. Travers | Visual Effects Supervisor |
| Michael Dilbeck | Music Supervisor |
| Charles Newirth | Unit Production Manager |
| Michele Panelli-Venetis | First Assistant Director |
| David Mendoza | Second Assistant Director |
| Jeffrey Lee Gibson | Stunt Coordinator |
| Lynda Thompson | Visual Effects Producer |
| Debbie Schwab | Production Supervisor |
| Gino Falsetto | Associate Producer |
| Daniel T. Dorrance | Supervising Art Director |
| Jennifer Gerbino | Property Master |
| Ronit Ravich-Boss | Script Supervisor |
| Gary Jay | "A" Camera Operator |
| Michael D. Weldon | First Assistant "A" Camera |
| Kirk Bloomberg | Second Assistant "A" Camera |
| Chris Moseley | "B" Camera Operator |
| Maurice K. McGuire | "B" Camera Operator |
| John Young | First Assistant "B" Camera |
| Tulio Duenas | Second Assistant "B" Camera |
| Douglas A. Degrazzio | Digital Imaging Technician |
| Mark Peterson | Costume Supervisor |
| Hillary Derby | Key Costumer |
| Patrick Guzzo | Costumer |
| Stephanie Carter | Costumer |
| Leslie Brown | Costumer |
| Adrian Garber | Costumer |
| Amanda Hannan | Costumer |
| Brendan Harvey | Costumer |
| Honah Lee Milne | Costumer |
| Ann Pala | Key Makeup Artist |
| Alexis Walker | Makeup Artist |
| Thomas Real | Key Hair Stylist |
| Jeff Murrell | Chief Lighting Technician |
| James R. Mitchell | Assistant Chief Lighting Technician |
| John Beran | Key Rigging Grip |
| John Janusek | Key Grip |
| John P. Shine | Best Boy Grip |
| Troy N. Wade | Dolly Grip |
| Dave Rudolph | Dolly Grip |
| David MacMillan | Production Sound Mixer |
| Perry Dodgson | Boom Operator |
| Ryan Baker | Utility Sound |
| Alfred Ainsworth | Video Assist Operator |
| Allen Hall | Special Effects Supervisor |
| Charles Harrington | Location Manager |
| Rob Frank | Location Manager |
| Joe Piasecki | Assistant Location Manager |
| Jenny Sandell | Production Coordinator |
| Paul Taglianetti | Visual Effects Coordinator |
| Patricia L. DeShields | Production Accountant |
| Rick Marcena | First Assistant Accountant |
| Amy Denning Winfrey | Payroll Accountant |
| Joseph Kearney | Construction Coordinator |
| David T. Parsons | Construction Foreman |
| Michael Tavani | Construction Foreman |
| John Stone | Construction Foreman |
| Jeff Plauster | Construction Foreman |
| Alberto Gonzalez-Reyna | Assistant Art Director |
| J. André Chaintreuil | Set Designer |
| Tom Frohling | Set Designer |
| Luis G. Hoyos | Set Designer |
| Carl Sprague | Set Designer |
| Jason Sweers | Graphic Designer |
| Pete von Sholly | Storyboard Artist |
| Robert Schleinig | Leadman |
| Aimee Butterfield | Assistant Property Master |
| Tammy Sandler | Unit Publicist |
| Tracy Bennett | Still Photographer |
| Chris Kiley | Second Second Assistant Director |
| Michelle Schrauwers | Second Second Assistant Director |
| Jacquelyn Palmquist | Casting Associate |
| Freya Krasnow | Casting Assistant |
| Meagan Lewis | Extras Casting |
| Michael "Mox" Pappas | Craft Service |
| Marguerite Pomerhn Derricks | Choreographer |
| Barry Bernardi | Second Unit Director |
| Perry Andelin Blake | Second Unit Director |
| Amy Vincent | Second Unit Director of Photography |
| Nathan Godley | First Assistant Editor |
| Pamela Choules | Visual Effects Editor |
| Patsy Bouge | Post Production Supervisor |
| Tateum Kohut | Sound Re-Recording Mixer |
| Greg Orloff | Sound Re-Recording Mixer |
| Elmo Weber | Supervising Sound Editor |
| Frank Gaeta | Supervising Sound Editor |
| Matthew P. Hanson | Assistant Sound Editor |
| Christopher T. Welch | Supervising ADR Editor |
| Kira Roessler | ADR Editor |
| Cameron Steenhagen | Dialogue Editor |
| Ralph Osborn | Dialogue Editor |
| Joe Lemola | Sound Effects Editor |
| Rickley W. Dumm | Sound Effects Editor |
| Paul Berolzheimer | Sound Effects Editor |
| Clayton Weber | Foley Editor |
| Catherine Harper | Foley Artist |
| Amy Kane | Foley Artist |
| Randy Singer | Foley Mixer |
| Stuart Grusin | Music Editor |
| J.J. George | Music Editor |
| Frank Wolf | Scoring Mixer |
| James Wright | Dolby Consultant |
| Jill Bogdanowicz | Digital Colorist |
| Eric Scott | Visual Effects Producer |
| Anna Venizelos | Stunts |
| Caroline Vexler | Stunts |
| Rosie Bernhard | Stunts |
| Alicia Vela-Bailey | Stunt Double |
| Aaron Vexler | Stunts |
| Chick Bernhard | Stunts |
