 | Hayden Christensen als Clay Beresford |
 | Jessica Alba als Sam Lockwood |
 | Terrence Howard als Dr. Jack Harper |
 | Lena Olin als Lilith Beresford |
 | Christopher McDonald als Dr. Larry Lupin |
 | Sam Robards als Clayton Beresford Sr. |
 | Arliss Howard als Dr. Jonathan Neyer |
 | Fisher Stevens als Dr. Puttnam |
 | Georgina Chapman als Penny Carver |
 | David Harbour als Dracula |
 | Steven Hinkle als Young Clay |
 | Denis O'Hare als Financial News Analyst |
 | Charlie Hewson als Brian the Orderly |
 | Court Young als Officer Doherty |
 | Poorna Jagannathan als Dr. Neyer's Nurse |
 | Joshua Rollins als Funeral Minister |
| Lee Wong als Mr. Waturi |
| Kae Shimizu als Asian Translator |
| Brenda Schad als Pregnant Woman |
| Ross Klavan als Financial News Analyst |
| Joby Harold | Director |
| Joby Harold | Writer |
| Joana Vicente | Producer |
| Jason Kliot | Producer |
| John Penotti | Producer |
| Fisher Stevens | Producer |
| Avy Kaufman | Casting |
| Russell Carpenter | Director of Photography |
| Cynthia Flynt | Costume Design |
| Craig McKay | Editor |
| Dina Goldman-Kunin | Production Design |
| Ben Barraud | Art Direction |
| Tora Peterson | Set Decoration |
| Chris Bingham | Makeup Department Head |
| Adam Roffman | Property Master |
| Michael Rubenstein | Scenic Artist |
| Pamela Lenau | Scenic Artist |
| Mary Frances Eglin | Art Department Coordinator |
| Richard Hebrank | Construction Coordinator |
| Joseph Proscia | Leadman |
| Dan Edelstein | Dialogue Editor |
| Mary Ellen Porto | Dialogue Editor |
| Nicholas Renbeck | Supervising Sound Editor |
| Nicholas Renbeck | Sound Re-Recording Mixer |
| Bob Chefalas | Sound Re-Recording Mixer |
| Wyatt Sprague | Sound Effects Editor |
| David Isyomin | Visual Effects Supervisor |
| Peter Bucossi | Stunt Coordinator |
| K.C. Bailey | Still Photographer |
| Hernán Otaño | Camera Operator |
| Jamie Silverstein | Camera Operator |
| Steve Ramsey | Gaffer |
| Jamie Silverstein | Steadicam Operator |
| Michael J. Maurer | Best Boy Electric |
| T. Ray Treece | Video Assist Operator |
| Matthew Reedy | Digital Intermediate |
| Missy Cohen | Music Editor |
| Anthony Pettine | Script Supervisor |
| Joe Sevey | Location Manager |
| Meredith Kaunitz | Translator |
| Shane Haden | Location Manager |
| Charlotte Fleck | Dialect Coach |
| Paul Hsu | Sound Designer |
| Harvey Weinstein | Executive Producer |
| Bob Weinstein | Executive Producer |
| Anna Hilton | Hair Department Head |
| Michelle Johnson | Hairstylist |
| Evelyne Noraz | Makeup Artist |
| Elizabeth Minot | Additional Set Dresser |
| Julio Palma | Additional Set Dresser |
| Paul Pitalo | Additional Set Dresser |
| Adam VanWagner | Art Department Production Assistant |
| Anu Schwartz | Assistant Property Master |
| Dominick Cocuzzo | Construction Grip |
| Pat Cocuzzo | Construction Grip |
| Anthony Klien | Construction Grip |
| Brandon Stewart | Construction Grip |
| Kelly Hemenway | Graphic Designer |
| T.W. John House | Key Construction Grip |
| Alex Quarles | Set Dresser |
| Steve Cascarelli | Set Dresser |
| David Cooney | Storyboard Artist |
| Pedro Hernández | Best Boy Grip |
| Tim McNulty | Camera Loader |
| Robert K. Feldmann | Dolly Grip |
| John Coots | Electrician |
| Avra Fox-Lerner | Electrician |
| Dan Kubicek | Electrician |
| Joe Nittoso | Electrician |
| Beth O'Brien | Electrician |
| Christopher G. Passalaqua | Electrician |
| Michael Rudolph | Electrician |
| Jeffrey Dutemple | First Assistant Camera |
| Jay Feather | First Assistant "B" Camera |
| John Schwartz | First Assistant "B" Camera |
| Jamison Grella | Generator Operator |
| George Elias | Grip |
| Justin Panzanaro | Grip |
| Gary Martone | Key Grip |
| David Skutch | Rigging Gaffer |
| Daniel Wiener | Second Assistant Camera |
| Christopher Moeller | Second Assistant "B" Camera |
| Amanda Slater | First Assistant Director |
| Trent Richmond | ADR Recordist |
| Rich Crescenti | ADR Recordist |
| Craig Kyllonen | ADR Recordist |
| Jan Petrov | ADR Recordist |
| Michael Feuser | Assistant Sound Editor |
| Lidia Tamplenizza | Assistant Sound Editor |
| John Gutierrez | Boom Operator |
| Marko Costanzo | Foley Artist |
| Mike Poppleton | Foley Editor |
| George A. Lara | Foley Mixer |
| Ruth Hernandez | Supervising ADR Editor |
| Peter Kunz | Special Effects |
| Sondra James | ADR Voice Casting |
| Frankie Ritacco | Assistant Costume Designer |
| Penelope Laughman | Costumer |
| Clifford Wray | Costumer |
| Colleen McTigue | Wardrobe Supervisor |
| Amy Pickering | Wardrobe Supervisor |
| Kate Eales | Co-Editor |
| Gordon Grinberg | Co-Editor |
| John Scott | Editorial Consultant |
| Valdís Óskarsdóttir | Editorial Consultant |
| James W. Harrison III | First Assistant Editor |
| Sarah Jean Porter | First Assistant Editor |
| Dan Lieberstein | Music Supervisor |
| Sean Hogan | Production Accountant |
| Maggie Engelhardt | Production Coordinator |
| Samantha Dyer | Production Secretary |
| Samantha MacIvor | Stunt Double |
| Stephanie Finochio | Stunt Double |
| Samuel Sim | Original Music Composer |
| Graeme Revell | Original Music Composer |
