 | Rob Corddry als Gary Supernova (voice) |
 | Brendan Fraser als Scorch Supernova (voice) |
 | Jessica Alba als Lena (voice) |
 | Steve Zahn als Hawk (voice) |
 | Sarah Jessica Parker als Kira Supernova (voice) |
 | Ricky Gervais als Mr Bing (voice) |
 | Gregg Binkley als Ralph (voice) (uncredited) |
 | Sofía Vergara als Gabby (voice) |
 | Kaitlin Olson als 3D Movie Girl (voice) |
 | Ashley Eckstein als Alien (voice) |
 | Craig Robinson als Doc (voice) |
 | Jane Lynch als Io (voice) |
 | George Lopez als Thurman (voice) |
 | Jonathan Morgan Heit als Kip Supernova (voice) |
 | Chris Parnell als Hammer (voice) |
 | William Shatner als General Shanker (voice) |
 | Bob Bergen als 3D Movie Guy (voice) |
 | Joshua Rush als Young Shanker (voice) |
 | Doug Abrahams als Hazmat / Baabian Citizen (voice) |
 | Sean Kenin als Radio Host (voice) |
 | Bill Hader als Announcer (voice) (uncredited) |
| Preston Stutzman | Producer |
| Matt Landon | Editor |
| Scott Winlaw | Editor |
| Jonathan Shestack | Producer |
| Cal Brunker | Director |
| Barry E. Jackson | Production Design |
| Matthias Lechner | Art Direction |
| Scott Underwood | Storyboard |
| Barry E. Jackson | Production Manager |
| Harvey Weinstein | Executive Producer |
| Bob Weinstein | Executive Producer |
| Aaron Zigman | Music |
| Bob Barlen | Writer |
| Cal Brunker | Writer |
| Tony Leech | Original Story |
| Cory Edwards | Original Story |
| Dave Paterson | Supervising Sound Editor |
| Damian Volpe | Sound Effects Editor |
| Glenfield Payne | Sound Effects Editor |
| Robert Hein | Sound Effects Editor |
| Wyatt Sprague | Sound Effects Editor |
| Gregg Swiatlowski | Assistant Sound Editor |
| Igor Nikolic | Assistant Sound Editor |
| Ben Burtt | Sound Designer |
| Craig Berkey | Sound Designer |
| Rachel Chancey | Foley Supervisor |
| Mary Ellen Porto | Foley Editor |
| George A. Lara | Foley Mixer |
| Marko Costanzo | Foley Artist |
| Bob Chefalas | Sound Re-Recording Mixer |
