 | Nicolas Cage als Benjamin Franklin Gates |
 | Diane Kruger als Abigail Chase |
 | Justin Bartha als Riley Poole |
 | Sean Bean als Ian Howe |
 | Jon Voight als Patrick Gates |
 | Harvey Keitel als Peter Sadusky |
 | Christopher Plummer als John Adams Gates |
 | David Dayan Fisher als Shaw |
 | Stewart Finlay-McLennan als Powell |
 | Oleg Taktarov als Shippen |
 | Stephen A. Pope als Phil |
 | Annie Parisse als Agent Dawes |
 | Mark Pellegrino als Agent Johnson |
 | Armando Riesco als Agent Hendricks |
 | Erik King als Agent Colfax |
 | Don McManus als Stan Herbert |
 | Ron Canada als Guard Woodruff |
 | Hunter Gomez als Young Ben Gates |
 | Deborah Yates als Rebecca |
 | Arabella Field als Abigail's Secretary |
 | Sharon Wilkins als Butcher Lady |
 | Alexandra Balahoutis als Clothing Store Clerk |
 | Dior Raye als Gift Store Clerk |
 | Yves Michel-Beneche als Museum Kid |
 | Jason Earles als Thomas Gates |
| Terrence Currier als Charles Carroll |
 | Rod McLachlan als Independence Hall Guide |
 | Elizabeth Greenberg als Liberty Bell Guide |
 | Jody Halse als Franklin Institute Guard |
 | Liam Noble als Franklin Institute Security |
 | Joshua Bitton als Technician |
| Michael Russo als Popcorn Vendor |
 | Fern D. Baguidy Jr. als Gala Guard |
| Thomas Q. Morris als Janitor |
 | Antony Alda als Guard Ferguson |
| John Travis als Guard Mike |
 | Heidi Albertsen als Intrepid Tourist (uncredited) |
 | Adriana Alveario als Shopper at Market (uncredited) |
| Jon Turteltaub | Producer |
| Trevor Rabin | Original Music Composer |
| Jon Turteltaub | Director |
| Jerry Bruckheimer | Producer |
| Marianne Wibberley | Screenplay |
| Cormac Wibberley | Screenplay |
| Jim Kouf | Screenplay |
| Caleb Deschanel | Director of Photography |
| William Goldenberg | Editor |
| John Trujillo | Layout |
| Judianna Makovsky | Costume Design |
| Avy Kaufman | Casting |
| Tommy Hooper | Color Timer |
| Angie Jones | Animation |
| Michael Uslan | Associate Producer |
| Benjamin Melniker | Associate Producer |
| Christina Steinberg | Executive Producer |
| Oren Aviv | Executive Producer |
| Mike Stenson | Executive Producer |
| Charles Segars | Executive Producer |
| Barry H. Waldman | Executive Producer |
| Chad Oman | Executive Producer |
| Pat Sandston | Associate Producer |
| Susan Antonelli | Set Costumer |
| Sean Andrew Faden | CG Supervisor |
| Anupam Das | 3D Supervisor |
| Norris Spencer | Production Design |
| Anne D. McCulley | Set Decoration |
| Frank Cappiello | Greensman |
| Henry Schaub | Standby Painter |
| Richard E. Birch | Propmaker |
| George Marshall Ruge | Stunt Coordinator |
| Alicia Accardo | Script Supervisor |
| Rod Farley | Rigging Grip |
| Mark Hitchler | Set Designer |
| Marcis Cole | Steadicam Operator |
| Courtney J. Andersen | Set Dressing Artist |
| Tami Goldman | Post Production Supervisor |
| Gary Rieck | Script Coordinator |
| Brett M. Reed | Assistant Editor |
| Andy Day | Gaffer |
| Dylan Rush | Lighting Technician |
| Canada Johanna Gordon | Art Department Coordinator |
| Don Harper | Additional Music |
| Dana Arnold | Best Boy Electric |
| Leigh-Alexandra Jacob | Lead Painter |
| Tammy DeRuiter | Painter |
| Michael Adkins | Costume Supervisor |
| Beatrice De Alba | Key Hair Stylist |
| Knar Kitabjian | Post Production Assistant |
| Jesse Kaplan | Video Assist Operator |
| Charley Armstrong | Location Manager |
| Pepper O'Brien | Production Accountant |
| Douglas C. Merrifield | Production Supervisor |
| Cary Weitz | Boom Operator |
| Bob Badami | Music Supervisor |
| Odin Benitez | Sound Editor |
| Jim Bridges | Still Photographer |
| Jack Carpenter | Driver |
| Grady Holder | Makeup Effects |
| Anthony Canard | Transportation Co-Captain |
| Bryce Guy Williams | Transportation Coordinator |
| William B. Kaplan | Sound Mixer |
| Bert Rodriguez | Construction Foreman |
| J.C. Brotherhood | Special Effects Coordinator |
| Kris Evans | Makeup Designer |
| Tony Swatton | Armorer |
| Marco Kyris | Stand In |
| Robin Beauchesne | Makeup Artist |
| Thomas M. Cornelius | Craft Service |
| Dick Deats | Grip |
| Erwin H. Kupitz | Wigmaker |
| Michael Buster | Dialect Coach |
| Daniel W. Barringer | Stunts |
| Ron Kunecke | Transportation Captain |
| Kate Brown | Production Coordinator |
| Michael Jonascu | Sound Effects Editor |
| George Watters II | Supervising Sound Editor |
| Brian Cuscino | I/O Supervisor |
| David Danon | Hairstylist |
| Russell Ayer | Electrician |
| Mitchell S. Drain | Visual Effects Supervisor |
| Darek Gogol | Production Illustrator |
| Marilyn Matthews | Assistant Costume Designer |
| Shelley Kirkwood | Unit Publicist |
| Andy Foster | Visual Effects Coordinator |
| William Hiney | Assistant Art Director |
| Anthony Carlino | Leadman |
| Ray De La Motte | Camera Operator |
| Richard J. Brock | Camera Technician |
| Bryan Badman | Carpenter |
| Kevin Craig | Picture Car Coordinator |
| Ray Chan | Supervising Art Director |
| Elizabeth Greenberg | Casting Associate |
| Doug Parker | First Assistant Sound Editor |
| Tom Calderaro | Orchestrator |
| Lawrence A. Hubbs | Art Direction |
| Greg John Callas | Construction Coordinator |
| Jonathan Reich | Location Scout |
| Michael Kelem | Helicopter Camera |
| Matt Danon | Hair Department Head |
| Michael Hilow | Utility Stunts |
| Albert Cho | Assistant Director |
| KristieAnne Reed | Executive In Charge Of Production |
| Kathy Chasen-Hay | Visual Effects Producer |
| Geoff Hubbard | Supervising Art Director |
| Pamela Bertini | Art Department Assistant |
| Donna E. Bloom | Unit Production Manager |
| Fred Arbegast | Sculptor |
| Louie DeMarco | First Assistant Camera |
| Rich Fellegara | Set Medic |
| Blondel Aidoo | Executive Visual Effects Producer |
| Jennifer Nash | Music Editor |
| Brian Callahan | Key Set Costumer |
| Vanessa Bendetti | Researcher |
| Robert Dawson | Title Designer |
| Rod Farley | Best Boy Grip |
| Vincent Guarriello | Key Construction Grip |
| David Gray | Assistant Editor |
| Christopher Amy | First Assistant Property Master |
| Ro Gorski | Executive Assistant |
| Malika R. Cohen | Production Secretary |
| William Catania | Special Effects Technician |
| Lloyd Barcroft | Dolly Grip |
| Christopher Reichel | Digital Intermediate Assistant |
| Jen Hutchinson | Controller |
| Jennifer Bender | Extras Casting |
| Jay Wejebe | Assistant Makeup Artist |
| Charles Grisham | Stunt Double |
| Ramiro 'Melo' Flores | Location Assistant |
| Hans Berggren | Second Second Assistant Director |
| Rhys Summerhayes | Third Assistant Director |
| Eric Laudadio | Assistant Camera |
| Cheryl Ryan | Location Production Assistant |
| Peter Hackman | Charge Scenic Artist |
| Nathan McGuinness | Senior Visual Effects Supervisor |
| David Castillo | Stunt Driver |
| Cody Beke | Casting Assistant |
| Lauren Brezner | Art Department Production Assistant |
| Colin J. Campbell | Chief Lighting Technician |
| Ted Spiegler | Key Rigging Grip |
| Barrett J. Leigh | Travel Coordinator |
| John McDonnell | Assistant Property Master |
| Laura Graham | ADR Editor |
| Lisa Fozzati | Location Coordinator |
| Doc Kane | ADR Mixer |
| Kimberly Harris | Supervising ADR Editor |
| Eric Glasser | Key Set Production Assistant |
| Anna Belaro-Rodriguez | Second Assistant Accountant |
| Christina Fong | Second Assistant Director |
| Monica Frommholz | Set Decorating Coordinator |
| Linda 'Sam' Glynn | Assistant Location Manager |
| Laura Connors | First Assistant Accountant |
| Denise A. Beale | Production Assistant |
| John T. Cucci | Foley Artist |
| Daniel Casey | Camera Loader |
| Michael Neal | Payroll Accountant |
| Andrew Campbell | Graphic Designer |
| Ron Barr | Digital Intermediate Editor |
| Gordon Goodwin | Conductor |
| Jeanette Browning | ADR Recordist |
| James Ashwill | Foley Mixer |
| Eric Amundsen | Second Assistant Camera |
| Barbara Harris | ADR Voice Casting |
| Heidi Psyk | Post Production Coordinator |
| Steven Masi | Pilot |
| Philip G. Atwell | Second Unit Director |
| David A. Arnold | Supervising Dialogue Editor |
| Mark T. Osborne | Colorist |
| Derek DiBiagio | Assistant Production Coordinator |
| Timothy Healy | Generator Operator |
| Mark Palmer | On Set Dresser |
| Carl Catanese | Set Buyer |
| Trevor Goring | Storyboard Artist |
| Sara Webster | Additional Production Assistant |
| Robert Griffon Jr. | Property Master |
| David V. Butler | Dialogue Editor |
| Julie Jones | Production Controller |
| Kevin O'Connell | Sound Re-Recording Mixer |
| Greg P. Russell | Sound Re-Recording Mixer |
| F. Hudson Miller | Sound Effects Editor |
| R.J. Palmer | Sound Effects Editor |
| Suhail Kafity | Sound Effects Editor |
| Gary Wright | Sound Effects Editor |
| Allen Hartz | Dialogue Editor |
| Matthew Harrison | Foley Editor |
| Jim Likowski | Foley Editor |
| Victoria Martin | Foley Supervisor |
| Dan O'Connell | Foley Artist |
| Howard London | ADR Mixer |
| Jeanette Surga | Music Editor |
| Stephen Nakamura | Color Timer |
| Eric Engler | Second Unit Director of Photography |
| Scott H. Eddo | Makeup Artist |
| Dean Wolcott | Set Designer |
| Jim Kouf | Story |
| Oren Aviv | Story |
| Charles Segars | Story |
| Bob Minor | Stunts |
| Mark De Alessandro | Stunts |
| Tony Brubaker | Stunts |
| James M. Halty | Stunts |
| Steve Hart | Stunts |
| Lisa Hoyle | Stunt Double |
| Jim Stephan | Stunts |
| Paul M. Lane | Utility Stunts |
| Eddie Yansick | Stunts |
| Heidi Moneymaker | Stunts |
| Janet Paparazzo | Stunts |
| Harry Wowchuk | Stunts |
| Tom Morga | Stunts |
| Eric Norris | Stunts |
| Kurt D. Lott | Stunts |
| Richard L. Blackwell | Stunts |
| Charles Grisham | Stunts |
| Richard Bucher | Stunts |
| Peter Bucossi | Stunts |
| John Dixon | Stunts |
| Mic Rodgers | Second Unit Director |
| Jeremy Fry | Stunts |
| Mickey Giacomazzi | Stunts |
| Russell Towery | Stunts |
| Gene Hartline | Stunts |
