 | Ben Affleck als Sheriff Bryce Hammond |
 | Peter O'Toole als Dr. Timothy Flyte |
 | Rose McGowan als Lisa Pailey |
 | Joanna Going als Jennifer Pailery, M.D. |
 | Liev Schreiber als Deputy Stuart 'Stu' Wargle |
 | Nicky Katt als Deputy Steve Shanning |
 | Clifton Powell als Gen. Leland Copperfield |
 | Rick Otto als Scientist Lockland |
 | Valerie Chow als Scientist Yamaguchi |
 | Adam Nelson als Scientist Burke |
 | John Hammil als Scientist Talbot |
 | John Scott Clough als Scientist Shane |
 | Michael DeLorenzo als Soldier Velazquez |
 | William Hahn als Scientist Borman |
| Robert Himber als Scientist Walker |
 | Bo Hopkins als Agent Hawthorne |
 | Robert Knepper als Agent Wilson |
| Paul Schmidt als Church Soldier |
 | Dean Hallo als Sgt. Harker |
 | Clive Rosengren als Commanding Officer |
| Edmund Wyson als Cpl. Guthrie |
 | Lucas Elliot Eberl als Tunnel Boy |
 | Linnea Quigley als Woman in Room 204 |
 | Judith Drake als Hilda |
 | Yvette Nipar als Cowgirl |
| Dean R. Koontz | Screenplay |
| Joe Chappelle | Director |
| Randy Bricker | Editor |
| Dean R. Koontz | Novel |
| Don Phillips | Casting |
| Deborah Raymond | Production Design |
| Dorian Vernacchio | Production Design |
| Daniel Bradford | Art Direction |
| Ken Larson | Art Direction |
| Barbara Cole | Set Decoration |
| Dana Litwack | Costume Design |
| Laurie Borg | Line Producer |
| Enrique Cerezo | Associate Producer |
| Dean R. Koontz | Executive Producer |
| Harvey Weinstein | Executive Producer |
| Bob Weinstein | Executive Producer |
| Yoji Kurokami | Co-Executive Producer |
| Steven A. Lane | Producer |
| Michael Leahy | Producer |
| Richard Potter | Co-Executive Producer |
| Robert Pringle | Producer |
| Andrew Rona | Co-Executive Producer |
| Joel Soisson | Producer |
| Amanda Carroll | Key Makeup Artist |
| Joel Harlow | Special Effects Makeup Artist |
| Rob Hinderstein | Special Effects Makeup Artist |
| Vance Hartwell | Special Effects Makeup Artist |
| Paul Berolzheimer | Sound Effects Editor |
| Dean Beville | Sound Designer |
| Ricardo Broadus | Sound Effects Editor |
| Trip Brock | Sound Effects Editor |
| Richard Chaim | Sound |
| Harry Cohen | Sound Designer |
| Paul Curtis | ADR Editor |
| Elisabeth Flaum | Sound Effects Editor |
| Michael Kamper | Sound Effects Editor |
| Alan Kerr | Foley Artist |
| Jason Lezama | Foley Editor |
| Allen Hurd | Sound Recordist |
| David C. Williams | Original Music Composer |
| Richard Clabaugh | Director of Photography |
| Greg Littlewood | Additional Photography |
| Leah Rial | Key Makeup Artist |
| Dan Bradley | Stunt Coordinator |
| Dan Bradley | Second Unit Director |
| Lane Leavitt | Stunts |
| Mickey Giacomazzi | Stunts |
| Kathy Jarvis | Stunts |
