 | Lionel Barrymore als Dr. Josiah Glass |
 | Jean Arthur als Maria Theresa 'Terry' O'Reilly |
 | Chester Morris als Jeff Crane |
 | Joseph Calleia als Sonny 'Dinkie' Black |
 | Paul Kelly als Special Agent James Duff |
 | Lewis Stone als Prison Warden |
 | Paul Hurst als Rufe Parker |
 | George E. Stone als Butch |
 | Sam Baker als Mose Jones |
 | William Bailey als Federal Agent (uncredited) |
 | Brooks Benedict als Bar Patron (uncredited) |
 | Ed Brady als Convict in Prison (uncredited) |
 | Lane Chandler als Train Conductor (uncredited) |
 | Cora Sue Collins als Little Girl (uncredited) |
 | Helene Costello als Convict Wife (uncredited) |
 | Nell Craig als Duff's Secretary with Telegram (uncredited) |
 | Frank Darien als Dr. Hale - Plastic Surgeon (uncredited) |
 | James Flavin als Flavin - Federal Agent (uncredited) |
| Harry Geise als Convict (uncredited) |
 | John George als Convict (uncredited) |
 | Jonathan Hale als Prison Board Member (uncredited) |
 | Henry Hall als Restaurant Patron (uncredited) |
 | Lillian Harmer als Mrs. Higgins (uncredited) |
| Eddie Hart als Eddie - Sonny's Henchman (uncredited) |
 | Edward Hearn als Policeman in Pursuing Car (uncredited) |
 | Al Hill als Al - Sonny's Henchman (uncredited) |
 | Arthur Housman als Scottsdale Bar Drunk (uncredited) |
 | William Irving als Federal Agent (uncredited) |
 | Selmer Jackson als Simpson - Prison Board Member (uncredited) |
 | Gladden James als Federal Agent (uncredited) |
 | John Kelly als Federal Agent / Truck Driver Smuggling Gun (uncredited) |
 | Anderson Lawler als Higgins - Federal Agent (uncredited) |
 | Frank McGlynn Jr. als Federal Agent (uncredited) |
| Larry McGrath |
 | Greta Meyer als Glass' Housekeeper (uncredited) |
| Bob Montgomery als Brian - Sonny's Henchman (uncredited) |
| Bert Moorhouse als Federal Agent (uncredited) |
 | Frank Moran als Moran - Prison Guard (uncredited) |
| Philip Morris als Government Agent (uncredited) |
 | James C. Morton als Road House Patron (uncredited) |
 | Pat O'Malley als Federal Agent (uncredited) |
 | Jack Pennick als Bus Driver (uncredited) |
 | Lee Phelps als Tower Guard with Machine Gun (uncredited) |
 | Russ Powell als McGinnis - Hotel Bartender (uncredited) |
 | Stanley Price als Sonny's Henchman (uncredited) |
 | Frank Rice als Cab Driver (uncredited) |
 | Bert Roach als Salesman on Bus Annoying Terry (uncredited) |
 | Teru Shimada als Sam - Sonny's Japanese Houseboy (uncredited) |
 | Landers Stevens als Federal Man (uncredited) |
 | Carl Stockdale als Train Conductor (uncredited) |
 | Billy Sullivan als Undetermined Role (uncredited) |
 | Zeffie Tilbury als Deaf Woman in Scottsdale Bar (uncredited) |
 | Dorothy Vernon als Restaurant Patron (uncredited) |
 | Larry Wheat als Andrews - Prison Board Member (uncredited) |
| Bill Wolfe als Man on Dance Floor (uncredited) |
 | William Worthington als Prison Board Member (uncredited) |
 | Tammany Young als Bartender (uncredited) |
| Frank Bruno als Extra Leaving Theater (uncredited) |
| J. Walter Ruben | Story |
| J. Walter Ruben | Director |
| Wells Root | Screenplay |
| Wells Root | Story |
| Dolly Tree | Wardrobe Master |
| Frank Sullivan | Editor |
| Cedric Gibbons | Art Direction |
| Gregg Toland | Director of Photography |
| Hugh Boswell | Assistant Director |
| Douglas Shearer | Sound |
| Robert E. Barnes | Assistant Director |
| Edward Ward | Original Music Composer |
