 | James Arnold Taylor als Ratchet (voice) |
 | David Kaye als Clank (voice) |
 | Jim Ward als Captain Qwark (voice) |
 | Paul Giamatti als Chairman Drek (voice) |
 | Armin Shimerman als Dr. Nefarious (voice) |
 | Rosario Dawson als Elaris (voice) |
 | Bella Thorne als Cora Veralux (voice) |
 | Vincent Tong als Brax / Solana Trooper (voice) |
 | Andrew Cownden als Zed / Blarg (voice) |
 | Sylvester Stallone als Victor Von Ion (voice) |
 | John Goodman als Grimroth (voice) |
 | Lee Tockar als Mr. Micron (voice) |
 | Brian Dobson als Dallas Wannamaker / Announcer / Drek Computer (voice) |
 | Tabitha St. Germain als Juanita Alvaro (voice) |
 | Brad Swaile als Ollie / Super Fan (voice) |
 | Brian Drummond als Inspectobot / Warbot / Zurkons (voice) |
 | Cole Howard als Blarg (voice) |
 | Ian James Corlett als Blarg (voice) |
 | Alessandro Juliani als Solana Trooper (voice) |
 | Rebecca Shoichet als Stanley's Mom / Ship Computer (voice) |
| Don Briggs als Starship Commander (voice) |
| Braden Oberson | Editor |
| Ryan Schneider | Associate Producer |
| Richard Rionda Del Castro | Executive Producer |
| Anthony Di Ninno | Cinematography |
| Kylie Ellis | Producer |
| James Wood Wilson | Production Design |
| Harry Linden | Executive Producer |
| Kevin Munroe | Executive Producer |
| Jericca Cleland | Director |
| Michael Hefferon | Executive Producer |
| Brad Foxhoven | Producer |
| David Wohl | Producer |
| T.J. Fixman | Writer |
| Kaitlyn Fox | Lighting Artist |
| Kevin Munroe | Director |
| Kevin Munroe | Writer |
| Gerry Swallow | Writer |
| Ian Blum | Animation Director |
| Harry Linden | Line Producer |
| Brian Cleveland | Executive Producer |
| Jason Cleveland | Executive Producer |
| J.R. Fountain | Supervising Sound Editor |
| Nelson Ferreira | Supervising Sound Editor |
| Dashen Naidoo | Sound Effects Editor |
| Peter Persaud | Foley Recordist |
| Steve Baine | Foley Artist |
| Gina Wark | Assistant Foley Artist |
| Christian T. Cooke | Sound Re-Recording Mixer |
| Mark Zsifkovits | Sound Re-Recording Mixer |
| Fil Hosek | Sound Re-Recording Assistant |
| Lana Marie Hattar | Sound Re-Recording Assistant |
