 | William Powell als Philo Vance |
 | Mary Astor als Hilda Lake |
 | Eugene Pallette als Detective Heath |
 | Ralph Morgan als Raymond Wrede |
 | Robert McWade als District Attorney Markham |
 | Robert Barrat als Archer Coe |
 | Frank Conroy als Brisbane Coe |
 | Etienne Girardot als Dr. Doremus |
 | James Lee als Liang |
 | Paul Cavanagh als Thomas MacDonald |
 | Arthur Hohl als Gamble the Butler |
 | Helen Vinson als Doris Delafield |
 | Jack La Rue als Eduardo Grassi |
| Harry Allen als Sandy (uncredited) |
 | Wade Boteler als Desk Sergeant Mellish (uncredited) |
 | Don Brodie als Police Photographer (uncredited) |
 | James Burke als Policeman Who Lets Dog Out (uncredited) |
 | George Chandler als Reporter at Police Station (uncredited) |
 | Spencer Charters als Sergeant Snitkin (uncredited) |
 | Virginia Dabney als Girl (uncredited) |
 | Milton Kibbee als Reporter (uncredited) |
 | Harry Morgan als Gamble (uncredited) |
 | Henry O'Neill als Dubois (uncredited) |
 | Paul Panzer als Baggage Clerk (uncredited) |
| Cliff Saum als Policeman on Night Patrol (uncredited) |
 | Skippy als Terrier at Dog Show (uncredited) |
| Arthur Thalasso als Detective (uncredited) |
| Monte Vandergrift als Detective (uncredited) |
 | Leo White als Chicago Hotel Clerk (uncredited) |
 | Renee Whitney als Telephone Operator (uncredited) |
 | Charles C. Wilson als Detective Hennessy (uncredited) |
| Robert N. Lee | Screenplay |
| Peter Milne | Screenplay |
| S.S. Van Dine | Writer |
| Michael Curtiz | Director |
| Robert Presnell Sr. | Adaptation |
| William Rees | Director of Photography |
| Maxwell Arnow | Casting Director |
| Al Alleborn | Unit Manager |
| Herbert Plews | Props |
| Ray Heindorf | Orchestrator |
| Bernhard Kaun | Original Music Composer |
| Charles Althouse | Sound |
| Orry-Kelly | Costume Design |
| William P. Whitley | Assistant Camera |
| William Maybery | Casting Assistant |
| Harold McLernon | Editor |
| Owen Crompton | Grip |
| William C. McGann | Assistant Director |
| Russel Trost | Casting Associate |
| Lawrence Kennedy | Electrician |
| Kurt Rayfeld | Second Assistant Director |
| John Ellis | Still Photographer |
| Jack Okey | Art Direction |
| Leo F. Forbstein | Conductor |
