 | Vince Vaughn als Dan Trunkman |
 | Dave Franco als Mike Pancake |
 | Sienna Miller als Chuck Portnoy |
 | Tom Wilkinson als Timothy McWinters |
 | James Marsden als Jim Spinch |
 | June Diane Raphael als Susan Trunkman |
 | Nick Frost als Bill Whilmsley |
 | Ella Anderson als Bess Trunkman |
 | Anastasia Mousis Sanidopoulos als Farm Goer |
 | Melissa McMeekin als National Rental Clerk |
 | David C. Bunners als Pedestrian |
 | Frowin Wolter als Hostel Kid |
 | Britton Sear als Paul Trunkman |
| Kasia Malinowska als Craigslist Maid |
 | Michael Krabbe als Dandlin Desk Clerk |
 | Uwe Ochsenknecht als Maarten Daaervk |
 | Rainer Reiners als Tourist |
 | John Franchi als Professional Business Traveler |
 | Jil Funke als Pretty German Girl |
 | Bonita Friedericy als Helen (as Bonita Fri Edericy) |
 | Clement von Franckenstein als Armand (uncredited) |
 | Jeffrey Corazzini als Businessman (uncredited) |
 | Susan Garfield als Business Woman (uncredited) |
 | David Brückner als Band Singer on Stage (uncredited) |
 | Noelle Trudeau als Topless Pillow Girl (uncredited) |
 | Rebecca Olejniczak als Sexy Spa Girl (uncredited) |
 | Austin J. Ryan als Classmate (uncredited) |
| Steven Conrad | Writer |
| Ken Scott | Director |
| Todd Black | Producer |
| Charlie Woebcken | Co-Producer |
| Katharina Hingst | Second Unit |
| Oliver Stapleton | Director of Photography |
| Arnon Milchan | Producer |
| Jason Blumenthal | Producer |
| Steve Tisch | Producer |
| Anthony Katagas | Producer |
| Alex Wurman | Original Music Composer |
| Michael Tronick | Editor |
| Jon Poll | Editor |
| Rachel Tenner | Casting Director |
| Luca Tranchino | Production Design |
| Hinju Kim | Art Direction |
| Paul Richards | Art Direction |
| Astrid Sieben | Art Direction |
| Bernhard Henrich | Set Decoration |
| Liz Bernstrom | Makeup Department Head |
| Frank Barbosa | Hair Department Head |
| Sherryn Smith | Key Makeup Artist |
| David Bloomfield | Executive Producer |
| Matthew Wells | Post Production Coordinator |
| Spiro Razatos | Second Unit Director |
| Joe Bucaro III | Stunt Coordinator |
| Daniel Hourihan | Electrician |
| Steven Conrad | Executive Producer |
| Peter Teschner | Editor |
| Christoph Fisser | Co-Producer |
| Henning Molfenter | Co-Producer |
| Dave Jordan | Music Supervisor |
| Jojo Villanueva | Music Supervisor |
| David C. Robinson | Costume Designer |
| Anthony Katagas | Unit Production Manager |
| Doug Torres | First Assistant Director |
| Justin Ritson | Second Assistant Director |
