 | Julian Sands als Dr. Nick Cavanaugh |
 | Sherilyn Fenn als Helena |
 | Bill Paxton als Ray O'Malley |
 | Art Garfunkel als Dr. Lawrence Augustine |
 | Betsy Clark als Anne Garrett |
 | Kurtwood Smith als Dr. Alan Harrison |
 | Nicolette Scorsese als Fantasy Lover / Nurse |
 | Meg Register als Marion Cavanaugh |
| Bryan Smith als Russell |
| Marla Levine als Patricia |
| Kim Lentz als Nurse Diane |
| Lloyd T. Williams als Sam the Clerk |
 | Carl Mazzocone Sr. als Pastor |
| Erik Shoaff als Uncle Charlie |
| Lisa Oz als Flower Shop Girl |
 | Ted Manson als Mailman |
| Adele K. Schaeffer als Flashback Party Woman #1 |
| Amy Levin als Flashback Party Woman #2 |
| Matt Berry als Young Nick Cavanaugh |
 | D. Taylor Loeb als Laura (uncredited) |
| Philippe Caland | Story |
| Frank Byers | Director of Photography |
| Jennifer Lynch | Screenplay |
| Philippe Caland | Producer |
| Graeme Revell | Original Music Composer |
| Jennifer Lynch | Director |
| James R. Schaeffer | Executive Producer |
| Carl Mazzocone | Producer |
| Bojan Bazelli | Director of Photography |
| Larry Sugar | Executive Producer |
| David Finfer | Editor |
| Ferne Cassel | Casting |
| Laurel Ayn Selko | Associate Producer |
| Brigitte Caland | Associate Producer |
| Paul Huggins | Production Design |
| Sharon Braunstein | Set Decoration |
| Marcei A. Brown | Second Assistant Director |
| Josh King | First Assistant Director |
| David R. Kappes | Production Consultant |
| Richard Blake Wester | Property Master |
| Catherine Harper | Foley Artist |
| Todd Toon | Sound Effects Editor |
| Tami Treadwell | Foley Recordist |
| Syd Klinge | Assistant Editor |
| Ossama Khuluki | Foley Artist |
| Nina Port | Makeup Artist |
| Rhonda Guthrie | Second Second Assistant Director |
| J.L. Parker | Transportation Captain |
| Sonya Lunsford | Assistant Accountant |
| Gail Hunter | Script Supervisor |
| Kimberly Lowe Voigt | Dialogue Editor |
| Dawn Darfus | Production Accountant |
| Tully McCulloch | Best Boy Electric |
| David Bryden | Color Timer |
| Amy Stevens | Production Coordinator |
| Denise Bailie | Second Assistant Camera |
| Ken S. Polk | Sound Re-Recording Mixer |
| Ruth Leltman | Still Photographer |
| Dick Bernstein | Music Editor |
| Dane A. Davis | Supervising Sound Editor |
| Lonnie R. Smith Jr. | Stunt Coordinator |
| Kurt Nicholas Forshager | Foley Editor |
| Bayard Carey | Sound Mixer |
| Phyllis Housen | Assistant Editor |
| J.L. Parker | Stunt Driver |
| David Finfer | Post Production Coordinator |
| David Jobe | ADR Recordist |
| Candida Conery | Hairstylist |
| Brian Gunter | Gaffer |
| G.W. Brown | ADR Supervisor |
| Tom Hammond | Foley Editor |
| Denise Kaczmarczyk | Assistant Production Coordinator |
| Tommy Goodwin | Foley Mixer |
| Robert Thirlwell | Sound Re-Recording Mixer |
| Jimmy E. Jensen | First Assistant Camera |
| C. Ashley Sudge | Dolly Grip |
| Cindy Parker | Transportation Coordinator |
| Kini Kay | Sound Effects Editor |
| Martin J. Bram | Dialogue Editor |
| Robert Deschaine | ADR Mixer |
