 | Eddie Murphy als Prince Akeem / Clarence / Randy Watson / Saul |
 | Arsenio Hall als Semmi / Extremely Ugly Girl / Morris / Reverend Brown |
 | Shari Headley als Lisa McDowell |
 | John Amos als Cleo McDowell |
 | James Earl Jones als King Jaffe Joffer |
 | Madge Sinclair als Queen Aoleon |
 | Eriq La Salle als Darryl Jenks |
 | Allison Dean als Patrice McDowell |
 | Frankie Faison als Landlord |
 | Louie Anderson als Maurice |
 | Paul Bates als Oha |
 | Samuel L. Jackson als Hold-Up Man |
 | Vanessa Bell Calloway als Imani Izzi |
 | Calvin Lockhart als Colonel Izzi |
 | Vondie Curtis-Hall als Basketball Game Vendor |
 | Cuba Gooding Jr. als Boy Getting Haircut |
 | Feather als Rose Bearer #1 |
| Stephanie Simon als Rose Bearer #2 |
 | Garcelle Beauvais als Rose Bearer #3 |
 | Ruben Santiago-Hudson als Street Hustler |
| Birdie M. Hale als Elderly Passenger |
| Clyde Jones als Soul Glo Man |
 | Jim Abrahams als Face on Cutting Room Floor |
 | Victoria Dillard als Bather / Dancer |
| Felicia Taylor als Bather |
 | Midori als Bather |
| Sheila Johnson als Lady-in-Waiting |
 | Jake Steinfeld als Cab Driver |
 | Clint Smith als Sweets |
| Uncle Ray Murphy als Stu |
| Paulette Banoza als Soul Glo Woman |
 | Patricia Matthews als Devil Woman |
 | Mary Bond Davis als Big Stank Woman |
| Carla Earle als Tough Girl |
| Karen Owens als Ex-Siamese Twin / Dancer |
| Sharon Owens als Ex-Siamese Twin / Dancer |
| Lisa Gumora als Kinky Girl |
| June Boykins als Strange Woman |
| Janette Colon als Fresh Peaches |
| Vanessa Colon als Sugar Cube |
| Monique Mannen als Boring Girl / Dancer |
| Mindora Mimms als Awareness Woman |
| Cynthia Finkley als Awareness Woman |
| David Sosna als Cartier Delivery Man |
| Arthur Adams als Mr. Jenks |
| Loni Kaye Harkless als Mrs. Jenks |
 | Montrose Hagins als Grandma Jenks |
| Tonja Rivers als Party Guest |
 | Ralph Bellamy als Randolph Duke / Homeless Man #1 (uncredited) |
 | Don Ameche als Mortimer Duke / Homeless Man #2 (uncredited) |
| Karl Denson als 'Sexual Chocolate' Saxophonist (uncredited) |
 | Elaine Kagan als Telegraph Lady (uncredited) |
 | Michael Tadross als Taxi Driver (uncredited) |
 | Steve White als Subway Guy (uncredited) |
 | Helen Hanft als Subway Lady (uncredited) |
| Leah Aldridge als Dancer (uncredited) |
| Aurorah Allain als Dancer (uncredited) |
| Paula Brown als Dancer (uncredited) |
| Dwayne Chattman als Dancer (uncredited) |
| Stephanie Clark als Dancer (uncredited) |
| Robin L. Dimension als Dancer (uncredited) |
| Shaun Earl als Dancer (uncredited) |
| Eric L. Ellis als Dancer (uncredited) |
| Sharon Ferrol-Young als Dancer (uncredited) |
| Eric D. Henderson als Dancer (uncredited) |
| Gigi Hunter als Dancer (uncredited) |
| Debra Johnson als Dancer (uncredited) |
 | Tanya Lynne Lee als Dancer (uncredited) |
| Jimmy Locust als Dancer (uncredited) |
| Donna M. Perkins als Dancer (uncredited) |
| Dionne Rockhold als Dancer (uncredited) |
| Gina Consuela Rose als Dancer (uncredited) |
| Randolph Scott als Dancer (uncredited) |
| Robbin Tasha-Ford als Dancer (uncredited) |
| Jerald Vincent als Dancer (uncredited) |
| Eyan Williams als Dancer (uncredited) |
| Roy Milton Davis als Homeless Man Around Garbage Can Bonfire (uncredited) |
| Dorian DeMichele als Viola (uncredited) |
| Alison Gordy als Blond Hooker / Bag Lady in Fast Food Place (uncredited) |
| Mary Young als Stuck-Up Girl (uncredited) |
 | Tobe Hooper als Party Guest (uncredited) |
| Raymond D. Turner als T-Shirt Hawker |
| Sol Negrin | Director of Photography |
| Malcolm Campbell | Editor |
| Barry W. Blaustein | Screenplay |
| Nile Rodgers | Original Music Composer |
| David Sheffield | Screenplay |
| Robert D. Wachs | Producer |
| George Folsey Jr. | Producer |
| Mark Lipsky | Executive Producer |
| Leslie Belzberg | Executive Producer |
| Woody Omens | Director of Photography |
| George Folsey Jr. | Editor |
| John Landis | Director |
| David Sosna | Associate Producer |
| Richard B. Lewis | Art Direction |
| Gregg H. Bilson | Property Master |
| Frank Graziadei | Sound Recordist |
| Terry Ladin | Production Coordinator |
| Francine Jamison-Tanchuck | Costume Supervisor |
| Rick Baker | Makeup Effects |
| Greg Knapp | Set Medic |
| John Sherrod | Stunt Coordinator |
| Bob Noland | Color Timer |
| Daniel Allan Carlin | Music Editor |
| Paul Timothy Carden | Supervising Sound Editor |
| Christopher Nowak | Art Direction |
| Jerry Fitzpatrick | Construction Coordinator |
| Patrick Hogan | Driver |
| Charles Miller | Location Manager |
| William Apperson | Construction Foreman |
| Richie Ford | Electrician |
| Carole Lee Cole | Assistant Art Director |
| Bruce Atwater | Grip |
| Gerald DeTitta | Set Dressing Artist |
| Saul Kahan | Unit Publicist |
| John Ashby | Utility Stunts |
| Mike Dobie | Sound Editor |
| Kelly Kimball | Assistant Costume Designer |
| Lindell Blake | Stunts |
| Eddie Murphy | Story |
| Michael Tadross | Unit Production Manager |
| Spike Allison Hooper | Assistant Sound Editor |
| Deborah Nadoolman | Costume Design |
| Ken Fisher | First Assistant Camera |
| Rolf John Keppler | Makeup Artist |
| Cary Kelley | Transportation Coordinator |
| Richard Macdonald | Production Design |
| Eddie Jones | Craft Service |
| Michael T. James | Rigging Grip |
| Danny Cangemi | Special Effects Supervisor |
| Marc Fambro | Carpenter |
| Janet L. Wattles | Production Accountant |
| Dan von Blomberg | Set Decoration |
| Paula Abdul | Choreographer |
| David Sosna | First Assistant Director |
| Louis Sabat | Boom Operator |
| Jackie Burch | Casting |
| R. Gilbert Clayton | Set Designer |
| Cheryal Kearney | Set Decoration |
| Philip C. Hurst | Greensman |
| Bruce McBroom | Still Photographer |
| Edward Garzero | Scenic Artist |
| William B. Kaplan | Sound Mixer |
| Stan Cockerell | Assistant Property Master |
| Chris Schutsky | Location Assistant |
| John W. DeBlau | Chief Lighting Technician |
| Martha Appel | Production Assistant |
| Dennis Gamiello | First Company Grip |
| William Howard | Assistant Hairstylist |
| Joseph Cosko Jr. | Second Assistant Camera |
| Marie Carter | Assistant Makeup Artist |
| Jon Falkengren | Dolly Grip |
| Brian Fitzsimons | Second Company Grip |
| Bill Christians | Wardrobe Supervisor |
| Carlton Holder | Stunt Double |
| John Haggar | Assistant Editor |
| Rae Lockett | Extras Casting Assistant |
| Richard Patrick | Second Assistant Director |
| James Beshears | Supervising ADR Editor |
| Ed Cooper | Assistant Chief Lighting Technician |
| Joseph Banks | Generator Operator |
| Brian Stewart | Story Editor |
| Richard Evans | Swing |
| Charles Brescia | Additional Second Assistant Director |
| Dean Drabin | Foley Mixer |
| Madelyn Most | Assistant Camera |
| Ferne Cassel | Casting Assistant |
| Tomaz Remec | Second Second Assistant Director |
| Ginny Warner | Production Secretary |
| Rick Baker | Makeup Artist |
