 | George Clinton als Host |
 | Robert Guillaume als Gleason Golightly (segment 'Space Traders') |
 | Michele Lamar Richards als Gail Golightly (segment 'Space Traders') |
 | Jason Bernard als Bernard Shields (segment 'Space Traders') |
 | Edward Edwards als Chief of Staff (segment 'Space Traders') |
 | George Wallace als Piggy (segment 'Space Traders') |
 | Brian Reddy als Vice President (segment 'Space Traders') |
 | Larry Anderson als Stryker O'Rourke (segment 'Space Traders') |
 | Brock Peters als Minister Coombs (segment 'Space Traders') |
 | Bob Gunton als President Ellis (segment 'Space Traders') |
 | Nicholas Turturro als Father Carlos (segment 'The First Commandment') |
 | Efrain Figueroa als Padrino (segment 'The First Commandment') |
 | Richard Herd als Cardinal (segment 'The First Commandment') |
 | Paula Jai Parker als Tang (segment 'Tang') |
 | Chi McBride als T-Bone (segment 'Tang') |
 | Bertice Berry als (segment 'Space Traders') |
 | Franklin Cover als (segment 'Space Traders') |
 | Casey Kasem als (segment 'Space Traders') |
 | Roxie Roker als (segment 'Space Traders') |
 | Ebonie Smith als Jennifer (segment 'Space Traders') |
 | Craig Kirkwood als Lenny (segment 'Space Traders') |
| Liz Larou als Ute (segment 'Space Traders') |
| Jaye Koch als Alien Press Secretary (segment 'Space Traders') |
| Tom Williams als Education Secretary (segment 'Space Traders') |
| Marte Boyle Slout als Helen Hipmeyer (segment 'Space Traders') |
 | Joseph G. Medalis als Defense Secretary (segment 'Space Traders') |
 | James Noah als Interior Secretary (segment 'Space Traders') |
| Tom Finnegan als General Wright (segment 'Space Traders') |
 | Arthur Burghardt als Justin Jasper (segment 'Space Traders') |
 | Roger Guenveur Smith als Dr. Erik Fanon (segment 'Space Traders') |
| Roger Marks als Rabbi Spector (segment 'Space Traders') |
 | Lamont Johnson als Civil Rights Leader (segment 'Space Traders') |
| Jedda Jones als Woman in Audience (segment 'Space Traders') |
 | Robert Covarrubias als Hispanic Leader (segment 'Space Traders') |
| Cynthia Madvig als Cigarette Girl (segment 'Space Traders') |
 | Jim Jansen als Liquor Company CEO (segment 'Space Traders') |
| Dennis Howard als Petroleum Co. CEO #1 (segment 'Space Traders') |
| Paul Kent als Petroleum Co. CEO #2 (segment 'Space Traders') |
 | Steve Stapenhorst als Home Products CEO (segment 'Space Traders') |
 | Ann Walker als Audience Member #1 (segment 'Space Traders') |
 | Myra J. als Audience Member #2 (segment 'Space Traders') |
 | J. Kenneth Campbell als Mr. Spivey (segment 'The First Commandment') |
 | Daryl Mitchell als Mover #1 (segment 'The First Commandment') |
| Eugene Allen als Mover #2 (segment 'The First Commandment') |
 | Noëlle Balfour als The Saint (segment 'The First Commandment') |
 | Robert Wisdom als Captain Jackson (segment 'The First Commandment') |
 | Marcus Salgado als Young Man in the Botanica (segment 'The First Commandment') |
| George Logan als Male Drug Dealer (segment 'The First Commandment') |
 | Kelly Jo Minter als Female Drug Dealer (segment 'The First Commandment') |
 | Ana Mercedes als Blessed Woman (segment 'The First Commandment') |
 | John Witherspoon als Homeless Man #1 (segment 'The First Commandment') |
| Chino 'Fats' Williams als Homeless Man #2 (segment 'The First Commandment') |
 | Bowlegged Lou als Homeless Man #3 (segment 'The First Commandment') |
 | Peter Vogt als T.V. Reporter (segment 'The First Commandment') |
| Roma Alvarez als Old Lady at Church (segment 'The First Commandment') |
 | Paul Anthony als Crack House Thug #1 (segment 'The First Commandment') |
 | B-Fine als Crack House Thug #2 (segment 'The First Commandment') |
| Tony Canty als Santeria Practitioner (segment 'The First Commandment') |
| Janus Brown als Santeria Practitioner (segment 'The First Commandment') |
| Bobby Mateos als Santeria Practitioner (segment 'The First Commandment') |
| Joey DeLeon als Santeria Practitioner (segment 'The First Commandment') |
| Robert Melendez als Santeria Practitioner (segment 'The First Commandment') |
| Margaux Dinerman als Santeria Practitioner (segment 'The First Commandment') |
| Noah Nichel als Santeria Practitioner (segment 'The First Commandment') |
| Felicidad Gongora als Santeria Practitioner (segment 'The First Commandment') |
| Henry Williams als Santeria Practitioner (segment 'The First Commandment') |
| Irma Williams als Oshun (segment 'The First Commandment') |
 | Reno Wilson als The Messenger (segment 'Tang') |
| Reginald Hudlin | Executive Producer |
| Warrington Hudlin | Executive Producer |
| Reginald Hudlin | Creator |
| Eileen Mack Knight | Casting |
| John Barnes | Original Music Composer |
| Bryan Jones | Production Design |
| Richard Candib | Editor |
| Peter Deming | Director of Photography |
| Ernest Johnson | Producer |
| Trey Ellis | Writer |
| Derrick Bell | Short Story |
| Reginald Hudlin | Director |
| Stephen Semel | Editor |
| Warrington Hudlin | Writer |
| Warrington Hudlin | Director |
| Victor Du Bois | Editor |
| Kyle Baker | Teleplay |
| Chester Himes | Short Story |
| Kevin Rodney Sullivan | Director |
| Ernest Johnson | Unit Production Manager |
| Richard Alexander Wells | First Assistant Director |
| Babu Subramaniam | Second Assistant Director |
| Simone Farber | Second Assistant Director |
| Joseph N. Linsalata | Second Second Assistant Director |
| Dawn Todd Curfman | Production Coordinator |
| Jayne-Ann Tenggren | Script Supervisor |
| Nili Sinai | Script Supervisor |
| Michael Jarvis | Location Manager |
| Violette Jones-Faison | Costume Designer |
| Don Davis | First Assistant Camera |
| Bill H. Roberts Jr. | Second Assistant Camera |
| Kurt Braun | Steadicam Operator |
| David Chornow | Production Sound Mixer |
| Lisa K. Ferguson | Camera Loader |
| Walter Anderson | Boom Operator |
| Steve Karman | Art Direction |
| Michael C. Claypool | Set Decoration |
| Chris Dileo | Leadman |
| J.P. Jones | Property Master |
| Sharlene Williams | Costumer |
| Jennifer Leigh-Scott | Set Costumer |
| Judy Murdock | Makeup Artist |
| LaLette Littlejohn | Assistant Makeup Artist |
| Michael Burnett | Special Effects Makeup Artist |
| Albeir Awad | Wig Designer |
| Linda Stevenson-Khan | Hairstylist |
| Fay Kelly | Assistant Hairstylist |
| Kevin Wadowski | Key Grip |
| Michael LaViolette | Gaffer |
| Jon Philion | Best Boy Electric |
| Michael Stocks | Best Boy Grip |
| Monica R. Cooper | Extras Casting |
| Jim Stephan | Stunts |
| Eugene Collier | Stunts |
| LaFaye Baker | Stunts |
| Bruce K. Long | Visual Effects Producer |
| Scott Enyart | Visual Effects Supervisor |
| Richard Hiltzik | Online Editor |
| Howard Scott Stein | Online Editor |
| J. Stanley Johnston | Supervising Sound Editor |
| Alan Porzio | Sound Effects Designer |
| Tom Kearney | Dialogue Editor |
| Gerry Lentz | Sound Mixer |
| J. Stanley Johnston | Sound Mixer |
| Barbara Harris | ADR Voice Casting |
| Michael Jay Hill | Producer |