 | Karthi als Varun |
 | Aditi Rao Hydari als Dr. Leela |
 | Balaji Patturaj als Dr. Illyaas Hussain |
 | Rukmini Vijayakumar als Dr. Nidhi |
 | KPAC Lalitha als Achamma |
 | Shraddha Srinath als Girija Kapoor |
 | Delhi Ganesh als Col. Mithran |
 | Sivakumar Ananth als Girish Reddy |
 | Vipin Sharma als Dr. Leela's Father |
 | Mir Sarwar als Muzaffar Khan |
 | Harish Raj als Madhusoodhanan Pillai |
| Dhyana Madan als Rohini |
| Supyarde Singh als VC's sister-in-Law |
| Bejoy Nambiar als Cameo as Bus Passenger |
 | Anand Krishnamoorthi als Cameo as Bus Passenger |
| A.R. Rahman | Original Music Composer |
| Mani Ratnam | Director |
| Ravi Varman | Director of Photography |
| Sreekar Prasad | Editor |
| Mani Ratnam | Producer |
| Mani Ratnam | Screenplay |
| Brinda | Choreographer |
| C H Balu | Still Photographer |
| Sharmishta Roy | Production Design |
| P. S. Keerthana | Assistant Director |
| Shalini Shankar | Line Producer |
| Anand Krishnamoorthi | Sound Designer |
| S. Sivakumar | Sound Mixer |
| Arun S Mani | Foley Editor |
| P. C. Vishnu | Foley Editor |
| Durga Chiranjeevi | Sound Editor |
| Serina Tixeira | Makeup Artist |
| Sandeep Mane | Visual Effects Producer |
| Bejoy Nambiar | Creative Producer |
| Mani Ratnam | Story |
| Mani Ratnam | Dialogue |
| Sham Kaushal | Stunt Coordinator |
| Jonita Gandhi | Playback Singer |
| Eka Lakhani | Costume Designer |
| A. Amaran | Art Direction |
| Richard Anthony | Assistant Director |
