 | Angela Bettis als May Dove Canady |
 | Jeremy Sisto als Adam Stubbs |
 | Anna Faris als Polly |
 | James Duval als Blank |
 | Nichole Hiltz als Ambrosia |
 | Kevin Gage als Papa Canady |
 | Merle Kennedy als Mama Canady |
 | Chandler Riley Hecht als Young May |
| Rachel David als Petey |
 | Nora Zehetner als Hoop |
 | Will Estes als Chris, Adam's Roommate |
 | Roxanne Day als Buckle |
| Samantha Adams als Lucille |
 | Brittney Lee Harvey als Diedre |
 | Ken Davitian als Foreign Doctor |
| Jude McVay als Zombie |
 | Lucky McKee als Guy Making Out in Elevator |
| Tricia Kelly als Amy |
| Traci Burr als Short Girl |
 | Jennifer Grant als Jill in 'Jack and Jill' |
| Meredith Hines als Woman at restaurant |
 | Jesse Hlubik als Jack in 'Jack and Jill' |
| Scott Sturgeon | Producer |
| Chris Sivertson | Editor |
| Lucky McKee | Director |
| Eric Koskin | Executive Producer |
| Debra Goldfield | Editor |
| Rian Johnson | Editor |
| Lucky McKee | Screenplay |
| John Veague | Executive Producer |
| Jaye Barnes Luckett | Original Music Composer |
| Marius Weisberg | Producer |
| Leslie Keel | Production Design |
| Charlie Gonzales | Art Direction |
| Lorri Jakubuv | Set Decoration |
| Marcelo Pequeño | Costume Design |
| Steve Yedlin | Director of Photography |
| Erick Jolley | Sound Designer |
| Sheryll Coulon | Still Photographer |
| Richard Middleton | Co-Producer |
| Shannon Makhanian | Casting |
| Randy Westgate | Special Effects Makeup Artist |
| Tanja Hrast | Assistant Makeup Artist |
| Eva Lohse | Key Makeup Artist |
| Eva Lohse | Special Effects Makeup Artist |
| Katalin Urszuly | Key Makeup Artist |
| Wendy Southard | Key Hair Stylist |
| Elizabeth Villamarin | Assistant Makeup Artist |
| Richard Middleton | Unit Production Manager |
| Susan Wichmann | Post Production Supervisor |
| Scott Nifong | Property Master |
| Jaron Presant | Gaffer |
| Jaron Presant | Second Unit Director of Photography |
| Lucky McKee | Music Supervisor |
| Brad Arnold | First Assistant Director |
| W. Alex Korp | Second Assistant Director |
| Kristen Rajterowski | Set Dresser |
| Scott Nifong | Special Effects |
| Ric San Nicholas | Special Effects |
| Virgil Sanchez | Special Effects |
| Jennifer Goldstein | Casting Associate |
| Paula Fabio | Costume Supervisor |
