 | Chevy Chase als Clark Griswold |
 | Beverly D'Angelo als Ellen Griswold |
 | Anthony Michael Hall als Rusty Griswold |
 | Imogene Coca als Aunt Edna |
 | Randy Quaid als Cousin Eddie |
 | Dana Barron als Audrey Griswold |
 | Eddie Bracken als Roy Walley |
 | Brian Doyle-Murray als Kamp Komfort Clerk |
 | Miriam Flynn als Cousin Catherine |
 | James Keach als Motorcycle Cop |
 | Eugene Levy als Car Salesman |
 | Frank McRae als Grover |
 | John Candy als Lasky, Guard at Walleyworld |
 | Christie Brinkley als Girl In The Red Ferrari |
 | Jane Krakowski als Cousin Vicki |
 | John P. Navin, Jr. als Cousin Dale |
 | Nathan Cook als Man Giving Directions |
 | Christopher Jackson als Pimp |
 | Mickey Jones als Mechanic |
 | John Diehl als Assistant Mechanic |
| Jeannie Dimter Barton als Dodge City Cashier |
 | Randy Lowell als Wyatt Earp |
| Virgil Wyaco II als Indian |
| Gerry Black als Davenport |
 | James Staley als Motel Desk Clerk |
| Adelaide Wilder als Car Hop |
 | Tessa Richarde als Motel Guest |
| Fritz Ford als Neighbor |
| Eric Stacey als Neighbor |
| Scott Perry als Swat Leader |
| Dennis Freeman als Policeman |
 | Michael Talbott als Cowboy |
| John Craigmile als Camel Rider |
 | Henry Gibson als Hotel clerk (uncredited) |
 | Harold Ramis als Car salesman (voice) (uncredited) |
| Sam Mercer | Location Manager |
| Phyllis Huffman | Casting |
| Bub Asman | Sound Editor |
| Harold Ramis | Director |
| Pembroke J. Herring | Editor |
| Jack T. Collis | Production Design |
| David R. Ellis | Stunts |
| Jophery C. Brown | Stunts |
| John Hughes | Screenplay |
| Susan Arnold | Casting |
| Victor J. Kemper | Director of Photography |
| Joe D. Mitchell | Set Decoration |
| Frank Griffin | Makeup Artist |
| Wayne Fitzgerald | Title Designer |
| Robert M. Stevens | Camera Operator |
| Glenn R. Wilder | Stunts |
| Matty Simmons | Producer |
| Ralph Burns | Original Music Composer |
| Martin Raymond Bolger | Sound Mixer |
| Lindsey Buckingham | Songs |
| Lindsey Buckingham | Vocals |
| Alan Greedy | Script Supervisor |
| Robert J. Visciglia Sr. | Property Master |
| Tony Epper | Stunts |
| Dick Ziker | Stunt Coordinator |
| Dick Ziker | Second Unit Director |
| John M. Woodward | Transportation Coordinator |
| Paul Vombrack | Second Unit Director of Photography |
| Tim Board | Assistant Editor |
| Adele Taylor | Hairstylist |
| Alan Robert Murray | Sound Editor |
| Earl Gilbert | Gaffer |
| Robert G. Henderson | Sound Editor |
| Elliott Marks | Still Photographer |
| Eugene Marks | Music Editor |
| Kevin Jewison | Second Assistant Camera |
| Hal Whitby | Boom Operator |
| Caryl Wickman | Dialogue Editor |
| Robert P. Cohen | First Assistant Director |
| Robert Grand | Unit Production Manager |
| Robert Grand | Associate Producer |
| Patrick Marshall | Rigging Gaffer |
| Earl Clark | Assistant Camera |
| Donah Bassett | Negative Cutter |
| Bernie Schwartz | Dolly Grip |
| Brooke Henderson Ward | Assistant Sound Editor |
| Richard J. Bayard | Construction Coordinator |
| Gaylin P. Schultz | Key Grip |
| Rhio Haessig | Best Boy Electric |
| Karen Holley | Leadman |
| Carl Barth | Second Unit Director |
| Ross Brown | Second Assistant Director |
| Sonny Van Hecke | Assistant Property Master |
