 | Cillian Murphy als J. Robert Oppenheimer |
 | Emily Blunt als Kitty Oppenheimer |
 | Matt Damon als Leslie Groves |
 | Robert Downey Jr. als Lewis Strauss |
 | Florence Pugh als Jean Tatlock |
 | Josh Hartnett als Ernest Lawrence |
 | Casey Affleck als Boris Pash |
 | Rami Malek als David Hill |
 | Kenneth Branagh als Niels Bohr |
 | Benny Safdie als Edward Teller |
 | Jason Clarke als Roger Robb |
 | Dylan Arnold als Frank Oppenheimer |
 | Tom Conti als Albert Einstein |
 | James D'Arcy als Patrick Blackett |
 | David Dastmalchian als William Borden |
 | Dane DeHaan als Kenneth Nichols |
 | Alden Ehrenreich als Senate Aide |
 | Tony Goldwyn als Gordon Gray |
 | Jefferson Hall als Haakon Chevalier |
 | David Krumholtz als Isidor Rabi |
 | Matthew Modine als Vannevar Bush |
 | Scott Grimes als Counsel |
 | Kurt Koehler als Thomas Morgan |
 | John Gowans als Ward Evans |
 | Macon Blair als Lloyd Garrison |
 | Harry Groener als Senator McGee |
 | Gregory Jbara als Chairman Magnuson |
 | Ted King als Senator Bartlett |
 | Tim DeKay als Senator Pastore |
 | Steven Houska als Senator Scott |
 | Petrie Willink als Dutch Student |
 | Matthias Schweighöfer als Werner Heisenberg |
 | Alex Wolff als Luis Alvarez |
 | Josh Zuckerman als Rossi Lomanitz |
 | Rory Keane als Hartland Snyder |
 | Michael Angarano als Robert Serber |
 | Emma Dumont als Jackie Oppenheimer |
 | Sadie Stratton als Mary Washburn |
 | Britt Kyle als Barbara Chevalier |
 | Guy Burnet als George Eltenton |
 | Tom Jenkins als Richard Tolman |
 | Louise Lombard als Ruth Tolman |
 | Michael Andrew Baker als Joe Volpe |
 | Jeff Hephner als Congressman |
 | Olli Haaskivi als Edward Condon |
 | David Rysdahl als Donald Hornig |
 | Josh Peck als Kenneth Bainbridge |
 | Jack Quaid als Richard Feynman |
 | Brett DelBuono als Concerned Scientist |
 | Gustaf Skarsgård als Hans Bethe |
 | James Urbaniak als Kurt Gödel |
 | Trond Fausa Aurvåg als George Kistiakowsky |
 | Devon Bostick als Seth Neddermeyer |
 | Danny Deferrari als Enrico Fermi |
 | Christopher Denham als Klaus Fuchs |
 | Jessica Erin Martin als Charlotte Serber |
 | Ronald Auguste als J. Ernest Wilkins |
 | Máté Haumann als Leo Szilard |
 | Olivia Thirlby als Lilli Hornig |
 | Jack Cutmore-Scott als Lyall Johnson |
 | Harrison Gilbertson als Philip Morrison |
 | James Remar als Henry Stimson |
 | Will Roberts als George C. Marshall |
 | Pat Skipper als James Byrnes |
 | Steve Coulter als James Conant |
 | Jeremy John Wells als AAF Officer |
 | Sean Avery als Weatherman |
 | Adam Kroeger als Army Captain |
 | Drew Kenney als Soldier |
 | Bryce Johnson als AAF Officer 2 |
 | Flora Nolan als Burn Victim |
 | Kerry Westcott als Laughing Woman |
 | Christina Hogue als Kissing Woman |
 | Clay Bunker als Kissing Man |
 | Tyler Beardsley als Weeping Man |
 | Maria Teresa Zuppetta als Consoling Woman |
 | Kate French als Presidential Aide |
 | Gary Oldman als Harry Truman |
 | Hap Lawrence als Lyndon Johnson |
 | Meg Schimelpfenig als Senator's Assistant (uncredited) |
 | Matt Snead als Reporter (uncredited) |
| Charles Roven | Producer |
| Christopher Nolan | Director |
| Christopher Nolan | Producer |
| Christopher Nolan | Writer |
| Emma Thomas | Producer |
| John Papsidera | Casting |
| Ellen Mirojnick | Costume Design |
| James Woods | Executive Producer |
| Steve DeCastro | Stunts |
| Danny Downey | Stunts |
| Hoyte van Hoytema | Director of Photography |
| Richard Molloy | Additional Second Assistant Director |
| Andy Thompson | Co-Producer |
| Ludwig Göransson | Original Music Composer |
| Adam Willis | Set Decoration |
| Terry Jackson | Stunts |
| Douglas Shamburger | Boom Operator |
| Jim Hewitt | Set Designer |
| Easton Michael Smith | Set Designer |
| Tom Foligno | First Assistant Editor |
| George Cottle | Stunt Coordinator |
| Jennifer Lame | Editor |
| Mike Chambers | Visual Effects Producer |
| Jo Kissack Folsom | Assistant Costume Designer |
| Mark Norby | Stunts |
| Ruth de Jong | Production Design |
| Mike Fay | Additional Editor |
| Andrew W. Bofinger | Set Decoration Buyer |
| Melinda Sue Gordon | Still Photographer |
| Lynda Foote | Costume Supervisor |
| Dan O'Connell | Foley Artist |
| Richard King | Sound Designer |
| Taylor Estevez | Propmaker |
| Nathan Kelly | Unit Production Manager |
| Tammy S. Lee | Set Designer |
| Scott R. Fisher | Special Effects Supervisor |
| Noelle King | Set Designer |
| Steve Gehrke | Script Supervisor |
| Kevin O’Connell | Sound Re-Recording Mixer |
| Jonas Kirk | Construction Coordinator |
| Patrick Baker | Driver |
| Hans Bjerno | Aerial Director of Photography |
| Alex Gibson | Sound Effects Editor |
| Hilton Clay Peres | Location Scout |
| Guillaume DeLouche | Property Master |
| Heather Elwell | Art Department Coordinator |
| Russell Farmarco | Dialogue Editor |
| Thomas Hayslip | Executive Producer |
| Thomas Hayslip | Unit Production Manager |
| Eric Luling | On Set Dresser |
| Ray Boniker | Assistant Editor |
| Andrew Blustain | Assistant Editor |
| Michael Thurman | Set Dresser |
| Justin O'Neal Miller | Set Designer |
| Andrew Bock | First Assistant Sound Editor |
| Sabrina Calley | Costumer |
| Dean Bailey | Stunt Driver |
| Eric Dvorsky | Aerial Camera Technician |
| Jason Gary | Best Boy Grip |
| Lauren Kelley | Art Department Assistant |
| Kelly A. Cook | Still Photographer |
| Giovanni Zelko | Lighting Technician |
| Jennifer Tremont | Hairstylist |
| Willie D. Burton | Sound Mixer |
| Christopher Flick | Foley Editor |
| Manning Tillman | First Assistant "B" Camera |
| Josh Lakatos | Stunt Driver |
| Nilo Otero | First Assistant Director |
| Katie L. Murphy | Key Costumer |
| Richard Lieberman | Props |
| Keith B. Davis | First Assistant "A" Camera |
| Simon Firsht | Additional Director of Photography |
| Francisco Sonic Kim | Rigging Grip |
| Michael T. Wilson | Assistant Editor |
| Gary Thomas Williams | Driver |
| Jaime Leigh McIntosh | Hair Department Head |
| Andrea Steele | Makeup Artist |
| Duffy Gaver | Stunts |
| Andrew Jackson | Visual Effects Supervisor |
| Kevin Caira | Transportation Coordinator |
| Ivelina Dobreva | Compositing Supervisor |
| Kyle Carden | Key Grip |
| Wynema Chavez | Ager/Dyer |
| Aaron Hurvitz | Location Scout |
| Martin J. Sherwin | Book |
| Patty Carey | Location Manager |
| Derek Lacasa | Stunt Double |
| Patrick D Baker | Driver |
| M. Shane Cates | Grip |
| Scott Wesley Ross | Assistant Editor |
| Ryan Monro | Dolly Grip |
| Susanne Mueller | Set Decoration Buyer |
| James A. Brewer | Assistant Editor |
| Joshua Sankar | Graphic Designer |
| Dennis Muscari | Location Manager |
| Mike Duffy | Visual Effects Producer |
| Aaron Schulte | Electrician |
| Greg Finnin | Assistant Property Master |
| Rachel Nowik | Assistant Property Master |
| Ahou Mofid | Key Hair Stylist |
| Michael Edward Smith | Location Manager |
| Leigh Mierke | Lighting Technician |
| Kerrin Jackson | Makeup Artist |
| Nick Ellsberg | First Assistant Editor |
| Adam Mohundro | Boom Operator |
| Giacomo Mineo | Visual Effects Supervisor |
| Joe Vitellaro | Rigging Grip |
| Josh Mar | Set Costumer |
| Jason McDonough | Leadman |
| Alice Pico | Costumer |
| Michael Timman | Set Dresser |
| Satoshi Yamazaki | Key Rigging Grip |
| Brian Udoff | Additional First Assistant Camera |
| Kaiser Clark | Driver |
| Steve Zvorsky | Electrician |
| Andrew Stahl | Second Assistant Director |
| Mary Bowman | Set Costumer |
| Danielle Vigil | Hairstylist |
| Rafael Lima | Unit Production Manager |
| Kai Bird | Book |
| Eric Maldonado | Assistant Location Manager |
| David Croley Broyles | Set Production Assistant |
| Christy Falco | Key Makeup Artist |
| Robert Aguirre | Assistant Art Director |
| Dixon McPhillips | Second Assistant Director |
| Nick LaRocca | Stunts |
| Jaron Whitfill | Camera Technician |
| Jay Trautman | Assistant Editor |
| Anthony Del Grosso | Location Assistant |
| Jesse Carmona | Second Second Assistant Director |
| Scott Riddle | Assistant Location Manager |
| Reese Price | Grip |
| Cheryl Cravedi | Set Costumer |
| Stephen Parsey | Visual Effects Production Manager |
| Brittnee Holmquist | Costumer |
| Meg Burke | Costumer |
| Lydia Fantini | Hairstylist |
| Sara Elia | Grip |
| Mallory Bradley | Costumer |
| Jake Cavallo | Assistant Art Director |
| Marta Trudnowska | Set Costumer |
| Carlo Corbin | Grip |
| Dianna Warren | Seamstress |
| William M. Lynch | Art Department Assistant |
| Michael D. Sullivan | Assistant Location Manager |
| Ashley Mohabir | Compositor |
| Jacob Bogatin | Lighting Technician |
| Geoff Dillow | Set Dresser |
| Maxwell Graves | Carpenter |
| Mark Gutierrez | Construction Foreman |
| Roxy Hua | Assistant Art Director |
| Bianca Medina-Montoya | Assistant Set Decoration |
| Bruno Panacciulli | Construction Coordinator |
| Frank Piercy | Painter |
| Liliia Radchenko | Props |
| Scott b Schmidt | Set Dresser |
| Susu Schwaber | Art Department Assistant |
| Amy Wallenberg | Set Decoration Buyer |
| Anthony Whitman | Set Decoration Buyer |
| Paul Crow Willis | Key Rigging Grip |
| Rebecca Leigh Adams | Set Costumer |
| Anya Zebroski | Costumer |
| Shannon Blaney | Assistant Location Manager |
| Rory Higgs | Location Scout |
| Douglass Jamison | Assistant Location Manager |
| Marissa Nodar | Assistant Location Manager |
| Jeremy Whalon | Driver |
| Laurie Pellard | Special Effects |
| J. David Wargo | Executive Producer |
| Ernest Nelms | Imaging Science |
