 | Kathryn Hahn als Rachel Biegler |
 | Paul Giamatti als Richard Grimes |
 | Kayli Carter als Sadie Barrett |
 | Molly Shannon als Cynthia Grimes |
 | John Carroll Lynch als Charlie Grimes |
 | Desmin Borges als Sam |
 | Denis O'Hare als Dr. Dordick |
 | Siobhan Fallon Hogan als Beth |
 | Emily Robinson als Charlotte Grimes |
 | Tracee Chimo als Caroline |
 | Amaya Press als Trick or Treat Girl |
 | Francesca Root-Dodson als Fiona |
 | Samantha Buck als Psychologist |
 | Kerry Flanagan als Receptionist |
 | Danny Deferrari als Jonathan |
 | Alyssa Cheatham als Caroline's Daughter |
 | Kelly Miller als Dr. Russell |
 | Fenton Lawless als Uncle Bob |
 | Gabrielle Reidy als Clinic Nurse #3 |
 | Caroline Martin als Clinic Nurse |
 | Hettienne Park als Female Doctor |
 | Maddie Corman als Liz |
 | Katrine Hoyt als Nurse with Devil Horns (uncredited) |
| Christos Voudouris | Director of Photography |
| Tamara Jenkins | Writer |
| Tamara Jenkins | Director |
| Brian A. Kates | Editor |
| Lauren Silver | Production Accountant |
| Susan Schectar | Key Hair Stylist |
| Noah Chamis | Electrician |
| Ford Wheeler | Production Design |
| Leah Katznelson | Costume Design |
| Karlee Fomalont | Casting Associate |
| Briana Kay Stodden | Post Production Assistant |
| Andy Eklund | Art Direction |
| Gerry Kim | Location Scout |
| JoJo Whilden | Still Photographer |
| Alyssa Boffoli | Second Assistant Director |
| Emilia Spirito | Art Department Coordinator |
| Joshua Bote | Loader |
| Nina Kuhn | Gaffer |
| Drew Verderame | Grip |
| Lauren Colbert | Costume Coordinator |
| Anthony Bregman | Producer |
| Jacqueline Jacobson Scarfo | Set Decoration |
| Tricia Holmes | Assistant Editor |
| Pablo Burn | Location Scout |
| Jack McKenna | Assistant Director |
| Seth Tallman | Boom Operator |
| Seacia Pavao | Still Photographer |
| Michael Lee Nirenberg | Camera Technician |
| Carmine Picarello | Boom Operator |
| Charles Johnston | Dolly Grip |
| Maxwell Velazquez | Set Production Assistant |
| Jared Burke | Stunt Coordinator |
| Stefanie Azpiazu | Producer |
| Caroline Aragon | First Assistant Director |
| Alejandro Ramia | Third Assistant Director |
| Royal Yates | Location Manager |
| Howard Paar | Music Supervisor |
| Ro Dempsey | Casting |
| Tony Osso | Script Supervisor |
| Natalie Hoffman | Art Department Assistant |
| Mathew Price | Production Sound Mixer |
| Rachel Jablin | Post Production Supervisor |
| Andrea Pappas | Production Supervisor |
| Brenna McGuire | Makeup Department Head |
| Loren Kane | Graphic Designer |
