 | Steve Carell als Gary/Commissioner (voice)/Live-Action Bighead |
 | Stephen Colbert als Ace/Dr. Brainio (voice)/Live-Action Dr. Brainio |
 | Bill Chott als Announcer (voice) |
 | Robert Smigel als Bighead/Lizardo/Half-Scary (voice) |
 | Jon Hamm als Live-Action Ace |
 | Jimmy Fallon als Live-Action Gary |
 | Ed Helms als Live-Action Half-Scary |
 | Fred Armisen als Live-Action Lizardo |
| David Wachtenheim | Director |
| Robert Smigel | Writer |
| Stephen Colbert | Writer |
| Akiva Schaffer | Writer |
| David Wachtenheim | Writer |
| Jason Woliner | Writer |
| Brian Reich | Writer |
| Dan Madia | Animation |
| Steve Jackett | Animation |
| Tom Wittee | Animation |
| Don McGrath | Animation |
| Dale Clowdis | Animation |
| David Wachtenheim | Animation |
| Mike Fisher | Audio Post Coordinator |
| Steven M. Gold | Original Music Composer |
| Jason Woliner | Director |
| Dina Moles | Producer |
| Neil Daly | Assistant Director |
| Aaron Phillips | Director of Photography |
| Justus McLarty | Production Manager |
| Graham Holly | CGI Director |
| Louie Zarkarian | Special Effects Makeup Artist |
| Brian Hemesath | Costume Design |
| Teri Bella | Set Decoration |
| Rhys Thomas | Post Production Producer |
| Adam Epstein | Editor |
| Brian Smyi | Stunt Coordinator |
| Alex Daniels | Stunt Coordinator |
| David Wachtenheim | Executive Producer |
| Robert Smigel | Producer |
| Robert Marianetti | Executive Producer |
| Robert Marianetti | Animation Manager |