 | David Spade als Kuzco (voice) |
 | John Goodman als Pacha (voice) |
 | Eartha Kitt als Yzma (voice) |
 | Patrick Warburton als Kronk (voice) |
 | Wendie Malick als Chicha (voice) |
 | Kellyann Kelso als Chaca (voice) |
 | Eli Russell Linnetz als Tipo (voice) |
 | Stephen J. Anderson als Additional Voices (voice) |
 | Bob Bergen als Bucky / Fly Stuck in Web (voice) |
 | Rodger Bumpass als Townspeople (voice) |
 | Robert Clotworthy als Guards (voice) |
 | Jennifer Darling als (voice) |
 | Patti Deutsch als Waitress (voice) |
 | John Fiedler als Old Man (voice) |
 | Miriam Flynn als The Piñata Lady (voice) |
 | Geri Lee Gorowski als (voice) |
 | Sherry Lynn als Woman #2 (voice) |
 | Danny Mann als Additional Voices (voice) |
 | Mickie McGowan als Woman #1 (voice) |
| D.F. Reynolds als (voice) |
 | Andre Stojka als Topo (voice) |
| Steve Susskind als (voice) |
 | Joe Whyte als Official (voice) |
 | Jack Angel als Villagers (voice) (uncredited) |
 | Mark Dindal als Kitty Yzma (voice) (uncredited) |
 | Bill Farmer als Villagers (voice) (uncredited) |
| Carole Jeghers als Jaguars (voice) (uncredited) |
 | Tom Jones als Theme Song Guy (voice) (uncredited) |
 | Patrick Pinney als Villagers (voice) (uncredited) |
 | Jess Harnell als Additional Voices (voice) |
 | Phil Proctor als Villagers (voice) (uncredited) |
 | Steven Weber als Narrator (voice) |
| Don Hahn | Executive Producer |
| Randy Fullmer | Producer |
| Tom Finan | Editor |
| David Reynolds | Screenplay |
| Mark Dindal | Director |
| Dean A. Zupancic | Sound Re-Recording Mixer |
| Chris Williams | Story |
| Mark Dindal | Story |
| Tim Allen | Animation |
| Paul Brizzi | Visual Development |
| James Baker | Animation |
| Paul Carrera | First Assistant Editor |
| Mary Hidalgo | Casting |
| Matthew Jon Beck | Casting |
| Tim Chau | Sound Designer |
| Paul A. Felix | Production Design |
| Ruth Lambert | Casting |
| Paul Silver | Music Editor |
| Terry Porter | Sound Re-Recording Mixer |
| John Debney | Original Music Composer |
| Colin Stimpson | Art Direction |
| Charles Paley | Music Editor |
| Pam Ziegenhagen | Editor |
| Thomas Baker | Director of Photography |
| Thomas Cardone | Co-Art Director |
| Mel Metcalfe | Sound Re-Recording Mixer |
| Roger Allers | Original Story |
| Jin Kim | Animation |
| David Biello | Assistant Production Manager |
| Monica Lago-Kaytis | Assistant Production Manager |
| Julie Vieillemaringe | Assistant Production Manager |
| Diana Blazer | Assistant Production Manager |
| Tod C. Marsden | Production Manager |
| Sue Bea Montgomery | Post-Production Manager |
| Frederika Pepping | Assistant Production Manager |
| Suzanne Henderson Holmes | Assistant Production Manager |
| Patricia Hicks | Associate Producer |
| Coralie Cudot-Lissillour | Production Manager |
| Patricia Feldstein-Reed | Assistant Production Manager |
| Mark Walton | Story |
| Jenni Magee-Cook | Assistant Production Manager |
| Tracey Miller-Zarneke | Assistant Production Manager |
| Michael De La Cruz | Assistant Production Manager |
| Doeri Welch Greiner | Assistant Production Manager |
| Berenice Le Maitre | Post Production Supervisor |
| Cathy McGowan Leahy | Assistant Production Manager |
| Ron Betta | Assistant Production Manager |
| Etienne Longa | Assistant Production Manager |
| Prudence Fenton | Development Producer |
| Elzbieta Araszkiewicz | Production Assistant |
| Dorothy McKim | Director of Operations |
| Joe Ranft | Thanks |
| Matthew Jacobs | Original Story |
| Chris Montan | Executive Music Producer |
| Don Hall | Story Artist |
| Doug Frankel | Story Artist |
| John Norton | Story Artist |
| Mark Kennedy | Story Artist |
| Mark Walton | Story Artist |
| Stephen J. Anderson | Story Artist |
| Sting | Songs |
| Sting | Lyricist |
| Dave Hartley | Lyricist |
| Nik Ranieri | Supervising Animator |
| Bruce W. Smith | Supervising Animator |
| Dale Baer | Supervising Animator |
| Tony Bancroft | Supervising Animator |
| Doug Frankel | Lead Animator |
| James Lopez | Lead Animator |
