 | Louis Calhern als Oliver Wendell Holmes |
 | Ann Harding als Fanny Bowditch Holmes |
 | Eduard Franz als Louis Brandeis |
 | Philip Ober als Owen Wister / Narrator (voice) |
 | Ian Wolfe als Adams |
 | Edith Evanson als Annie Gough |
 | Herbert Anderson als Baxter |
 | Richard Anderson als Reynolds |
 | Jimmy Lydon als Clinton |
 | David Alpert als Secretary (uncredited) |
 | Arthur Anderson als Court Clerk (uncredited) |
| Robert Board als Secretary (uncredited) |
| Marshall Bradford als Headwaiter (uncredited) |
| Morgan Brown als Justice (uncredited) |
 | Wheaton Chambers als Senator (uncredited) |
| Lyle Clark als Secretary (uncredited) |
 | Dick Cogan als Reporter (uncredited) |
| John Sturges | Director |
| Emmet Lavery | Screenplay |
| Armand Deutsch | Producer |
| David Raksin | Original Music Composer |
| Joseph Ruttenberg | Director of Photography |
| Ferris Webster | Editor |
| Cedric Gibbons | Art Direction |
| Arthur Lonergan | Art Direction |
| Edwin B. Willis | Set Decoration |
| Walter Plunkett | Costume Design |
| Francis Biddle | Book |
| Emmet Lavery | Theatre Play |
| Sydney Guilaroff | Hairstylist |
| John Truwe | Makeup Artist |
| William Tuttle | Makeup Artist |
| Joel Freeman | Assistant Director |
| Addison Schaumer Jr. | Assistant Director |
| Jack D. Moore | Art Direction |
| Douglas Shearer | Recording Supervision |
| A. Arnold Gillespie | Special Effects |
| Leo Arnaud | Orchestrator |
| Robert Franklyn | Orchestrator |
| Paul Marquardt | Orchestrator |
| David Raksin | Orchestrator |
| David Raksin | Conductor |
| Walter Coughlin | Stand In |
| Jack Jackson | Stand In |
| Myra Jones | Stand In |
