 | Idris Elba als Dr. Ben Bass |
 | Kate Winslet als Alex Martin |
 | Dermot Mulroney als Mark Robertson |
 | Beau Bridges als Walter |
 | Linda Sorensen als Pamela |
 | Mercy Myrdal als Sarah Bass |
 | Dania Nassar als Mrs. Qabbani |
 | Vincent Gale als Airline Customer Service |
 | Marci T. House als Airline Representative |
 | Lee Majdoub als Translator |
 | Andres Joseph als Dinner Guest |
 | Nancy Sivak als Nurse |
 | Bethany Brown als New York Waiter |
| Orval Roberts als Logging Truck Driver |
 | Lucia Walters als London Doctor (uncredited) |
 | Natasha Burnett als London Nurse (uncredited) |
 | Nadeen Lightbody als Partygoer (uncredited) |
 | Adam Lolacher als Joel (uncredited) |
| Hany Abu-Assad | Director |
| Chris Weitz | Screenplay |
| Charles Martin | Novel |
| Susan Hegarty | Dialect Coach |
| Tom Blacklock | Special Effects |
| Nicholas Dent | Dolly Grip |
| Renee Ehrlich Kalfus | Costume Design |
| Jon Lavender | Boom Operator |
| Alex Hanneman | Digital Compositors |
| Amanda Petura | Third Assistant Director |
| Jeff Mohs | Location Scout |
| Jenno Topping | Producer |
| Mandy Walker | Director of Photography |
| Sandra-Ken Freeman | Casting |
| Fred Berger | Executive Producer |
| Dylan Clark | Producer |
| Tim Macarthur | Assistant Director |
| J. Mills Goodloe | Writer |
| Peter Chernin | Producer |
| Cheryl Marion | Art Direction |
| Philip Needs | Second Assistant Director |
| Tony Beck | Leadman |
| Megan Tanner | Makeup Artist |
| David Ready | Producer |
| Paul Barry | First Assistant Director |
| Jeremiah Slovarp | Recording Supervision |
| Becki Cross Trujillo | Unit Production Manager |
| Christian Madera | Visual Effects Editor |
| Shannon Gottlieb | Set Decoration |
| Braden Haggerty | Camera Operator |
| Mark G. Alexander | Lighting Technician |
| Hans Bjerno | Aerial Director of Photography |
| Kimberly French | Still Photographer |
| Lana S. Krause | Assistant Costume Designer |
| James Steuart | Supervising Art Director |
| Cara E. Anderson | Special Effects |
| Sian Grigg | Makeup Artist |
| Thierry Tanguy | Unit Production Manager |
| Paul Benjamin | Special Effects Supervisor |
| Curtis Corona | Post Production Assistant |
| Carole Griffin | Costume Supervisor |
| Amira Diab | Associate Producer |
| Lee Percy | Editor |
| Angela O'Sullivan | Assistant Art Director |
| Korey J. Cauchon | Visual Effects Producer |
| Becki Cross Trujillo | Executive Producer |
| Candice Todesco | Assistant Sound Editor |
| Steve Jacks | Assistant Editor |
| Jeff Mohs | Location Manager |
| Robert Edwards | ADR Mixer |
| Johnny Gidcomb | ADR Voice Casting |
| Niki Charalambopoulos | Paint Coordinator |
| Vaughan V. Baker | Paint Coordinator |
| Patrice Vermette | Production Design |
| Janene Carleton | Stunt Double |
| Ramin Djawadi | Original Music Composer |
