 | Penelope Ann Miller als Dr. Margo Green |
 | Tom Sizemore als Lt. Vincent D'Agosta |
 | Linda Hunt als Dr. Ann Cuthbert |
 | James Whitmore als Dr. Albert Frock |
 | Clayton Rohner als Det. Hollingsworth |
 | Chi Muoi Lo als Dr. Greg Lee |
 | Thomas Ryan als Tom Parkinson |
 | Robert Lesser als Mayor Robert Owen |
 | Diane Robin als The Mayor's Wife |
 | Lewis van Bergen als John Whitney |
 | Constance Towers als Mrs. Harriet Blaisedale |
 | Francis X. McCarthy als Mr. George Blaisedale |
 | Audra Lindley als Dr. Matilda Zwiezic |
 | John Kapelos als McNally |
 | Tico Wells als Bailey |
 | Mike Bacarella als Bradley |
 | Gene Davis als Martini |
 | John DiSanti als Guard Wootton |
 | David Proval als Guard Johnson |
 | Jophery C. Brown als Guard Frederick Ford |
 | Don Harvey als Spota |
| Ronald Joshua Scott als Josh |
| Dave Graubart als Eugene |
| Santos Morales als Capt. Borne |
 | Ralph Seymour als Sergeant |
| Mandy Ingber als Donna |
 | Lyn Alicia Henderson als Perri Masai |
 | Brian Steele als Kothoga |
| Peter Hyams | Director |
| Douglas Preston | Novel |
| Lincoln Child | Novel |
| Amy Holden Jones | Screenplay |
| John Raffo | Screenplay |
| Rick Jaffa | Screenplay |
| Amanda Silver | Screenplay |
| Gale Anne Hurd | Producer |
| Sam Mercer | Producer |
| John Debney | Original Music Composer |
| Peter Hyams | Director of Photography |
| Steven Kemper | Editor |
| Richard Foreman Jr. | Still Photographer |
| Elinor Bardach | Costume Supervisor |
| Susan Schuler-Page | Hairstylist |
| Judith A. Cory | Key Hair Stylist |
| Joyce Kogut | Set Costumer |
| Mark Boucher | Set Dressing Artist |
| Stephen Abrums | Key Makeup Artist |
| Bruce Richter | Carpenter |
| John Alexander | Choreographer |
| Ronald E. Hairston | Craft Service |
| John 'D.J.' Des Jardin | Digital Effects Supervisor |
| Sean T. Stratton | Post Production Supervisor |
| Stephen S. Campanelli | Steadicam Operator |
| Penny Perry | Casting |
| Daniel J. Lester | Costume Design |
| Mark Gordon | Executive Producer |
| Gary Levinsohn | Executive Producer |
| Keith Dillin | Transportation Captain |
| Philip Harrison | Production Design |
| Donna Cline | Production Illustrator |
| James J. Murakami | Art Direction |
| John H. Anderson | Set Decoration |
| Gary Baugh | Assistant Art Director |
| Terry Scott | Construction Coordinator |
| Ciro Vuoso | Construction Foreman |
| Jeffrey Thomas | Greensman |
| Nigel A. Boucher | Leadman |
| Lee J. Jashinsky | Painter |
| Christoph Rittershausen | Sculptor |
| Linda A. King | Set Designer |
| George Kohut | Camera Operator |
| David Norris | Camera Technician |
| Jeff Hand | First Assistant Camera |
| David French | Grip |
| Rick Shuster | Aerial Coordinator |
| David J. Chamerski | Property Master |
| Michael Denering | Scenic Artist |
| Alison Sanford | Sound Recordist |
| Jeff Bruno | Stand In |
| Brian Smrz | Stunt Coordinator |
| May Boss | Stunts |
| Josh Kirschenbaum | Technical Supervisor |
| Robert Neilson | Transportation Coordinator |
| Mitchell Dean | Utility Stunts |
| Cara Latzel | Video Assist Operator |
| Clark Campbell | Visual Effects Editor |
| Jack Frost Sanders | First Assistant Director |
| Barbara Thaxton | Script Supervisor |
| Phil Hetos | Color Timer |
| Neal J. Anderson | Dialogue Editor |
| Ronald J. Pure Jr. | Electrician |
| Norman Ash | Lighting Technician |
| Paul Pav | Location Manager |
| Stiles White | Production Coordinator |
| Amanda Brand | Publicist |
| Raul A. Bruce | Boom Operator |
| Robert Batha | First Assistant Sound Editor |
| Bob Beher | Foley Editor |
| Thomas A. Carlson | Music Editor |
| Frank Bennett | Orchestrator |
| Tony Lamberti | Sound Designer |
| Peter J. Lehman | Sound Effects Editor |
| Gene S. Cantamessa | Sound Mixer |
| Glenn T. Morgan | Supervising Sound Editor |
| Mike Amron | 3D Animator |
| Gregory Elwood | Digital Compositors |
| Garry Elmendorf | Special Effects Supervisor |
| Rhonda C. Gunner | Visual Effects |
| Paul Taglianetti | Visual Effects Coordinator |
| Jennifer Bergman | Visual Effects Producer |
| Gregory L. McMurry | Visual Effects Supervisor |
| Jeff Gullo | Additional Editing |
| James Bancroft | Modeling |
| John S. Robertson | Dolly Grip |
| Eric W. Orbom | Art Direction |
| Nancy Takehara | Costumer |
| David Michael Katz | Second Assistant Director |
| Scott H.C. Delsner | Second Second Assistant Director |
| Frank L. Brown | Assistant Property Master |
| Tom Jung | Storyboard Artist |
| Christopher Assells | ADR Editor |
| Bob Baron | ADR Mixer |
| Ken Dufva | Foley Artist |
| Nerses Gezalyan | Foley Mixer |
| Matt Colleran | Foley Recordist |
| John J. Downey | Special Effects Technician |
| Cheryl Budgett | 2D Supervisor |
| Carl Paoli | Stunt Driver |
| Jeffrey P. Ackil | Assistant Camera |
| Morgan Michael Lewis | First Company Grip |
| Jennifer Bell | Second Assistant Camera |
| Ido Gondelman | CG Animator |
| Mark 'Crash' McCreery | Character Designer |
| Barbara Harris | ADR Voice Casting |
| Shaunda G. Jones | Casting Assistant |
| Chris Jackson | Assistant Editor |
| Theresa Repola Mohammed | Negative Cutter |
| Bonnie Bott | Assistant Location Manager |
| Kristin Dehnert | Location Assistant |
| John Debney | Conductor |
| Jim Brockett | Animal Coordinator |
| Michael Bilog | Assistant Accountant |
| John 'Fest' Sandau | Assistant Chief Lighting Technician |
| Mark R. Lindberg | Chief Lighting Technician |
| Johnny White | Extras Casting Assistant |
| Regina Prokop | Extras Casting Coordinator |
| Michael Roccuzzo | Payroll Accountant |
| Debbie Silverman | Production Assistant |
| Jason S. Gondek | Second Assistant Accountant |
| Stan Winston | Creature Effects Technical Director |
| Adam Shankman | Choreographer |
| Jophery C. Brown | Stunts |
| Walter Scott | Stunts |
| Linda Perlin | Stunts |
| Paul E. Short | Stunts |
| Dick Warlock | Stunts |
| John Branagan | Stunts |
| Richard E. Butler | Stunts |
| Michael Cassidy | Stunts |
| Dana Freitag | Stunt Double |
| Dean Raphael Ferrandini | Stunts |
| Tim Gallin | Stunts |
| Linda Fetters Howard | Stunts |
| Mark Harper | Stunts |
| Rick LeFevour | Stunts |
| Carol Neilson | Stunts |
| Sunnie Merrill | Stunts |
| Chere Rae | Stunts |
| David Walling | Stunts |
| P.K. West | Stunts |
| Kay Whipple | Stunts |
| Keith Woulard | Stunts |
| Will Leong | Stunt Double |
| Danny Lima | Stunts |
