 | James McAvoy als Victor Frankenstein |
 | Daniel Radcliffe als Igor |
 | Jessica Brown Findlay als Lorelei |
 | Andrew Scott als Inspector Turpin |
 | Freddie Fox als Finnegan |
 | Charles Dance als Frankenstein |
 | Daniel Mays als Barnaby |
 | Callum Turner als Alistair |
 | Bronson Webb als Rafferty |
 | Spencer Wilding als Nathaniel / Prometheus 2 |
 | Robin Pearce als Baron Bomine |
 | Di Botcher als Older Nun |
 | Eve Ponsonby als Orderly |
 | Will Keen als Surgeon |
 | Louise Brealey als Sexy Society Girl |
 | Nicola Sloane als Housekeeper |
 | Alistair Petrie als Chief Inspector |
 | Neil Bell als Huntsman |
 | Mark Gatiss als Dettweiler |
 | Guillaume Delaunay als Prometheus 1 |
 | Robert J. Fraser als Livery Man (uncredited) |
 | Valene Kane als Mrs. Winthrop (uncredited) |
 | Adrian Schiller als Dr. Clive (uncredited) |
| Paul McGuigan | Director |
| Max Landis | Screenplay |
| Mary Shelley | Novel |
| Mairi Bett | Co-Producer |
| Derek Dauchy | Executive Producer |
| Brittany Morrissey | Executive Producer |
| Fabian Wagner | Director of Photography |
| John Davis | Producer |
| Jina Jay | Casting |
| Andrew Hulme | Editor |
| Charlie Phillips | Editor |
| Eve Stewart | Production Design |
| Grant Armstrong | Supervising Art Director |
| Ravi Bansal | Art Direction |
| Oliver Carroll | Art Direction |
| Tom Weaving | Art Direction |
| Michael Standish | Set Decoration |
| Jany Temime | Costume Design |
| Jessie Frost | Casting Associate |
| Kevin Pratten | Costume Supervisor |
| Andrew Glen | Music Editor |
| Joss Skottowe | Armorer |
| Dave Evans | Armorer |
| Mark Clayton | Gaffer |
| James Summers | Rigging Gaffer |
| Alex Bailey | Still Photographer |
| Mike Valentine | Underwater Camera |
| Sebastian Barraclough | First Assistant Camera |
| Jason T. Clark | Researcher |
| Loulia Sheppard | Hairstylist |
| Nicola Mount | Hairstylist |
| Malwina Suwinska | Hairstylist |
| Frances Hannon | Hair Designer |
| Belinda Parish | Key Hair Stylist |
| Nicky Knowles | Makeup Artist |
| Belinda Parish | Makeup Artist |
| Frances Hannon | Makeup Designer |
| Ray Marston | Wigmaker |
| Susannah Brough | Art Department Assistant |
| Patrick Harris | Assistant Art Director |
| Marilyn Marcotte | Animation |
| Marco Foglia | Animation Supervisor |
| Julien Bolbach | CG Supervisor |
| Martin Waters | CG Supervisor |
| Louis Paré | CG Supervisor |
| Brooke Dibble | Conceptual Design |
| Paul Dimmer | Special Effects Supervisor |
| Christopher Goodman | Conceptual Design |
| Jess Lewington | Special Effects Coordinator |
| Rob Zeigler | VFX Editor |
| Garrett Wilson | VFX Editor |
| Marie Castrie | Visual Effects Coordinator |
| Valeria di Gabriele | Visual Effects Coordinator |
| Alberto Herrera | Visual Effects Coordinator |
| Erika Khanna | Visual Effects Coordinator |
| Adam Lawrence | Visual Effects Coordinator |
| Karen Payne | Visual Effects Coordinator |
| Teréz Koncz | Visual Effects Coordinator |
| Chris Wilson | Visual Effects Coordinator |
| Tom Balogh | Visual Effects Editor |
| Mark Carr | Visual Effects Editor |
| Anik Seguin | Visual Effects Editor |
| Christopher Raiche | Visual Effects Editor |
| Sona Pak | Visual Effects Producer |
| Andrea D'Amico | Visual Effects Producer |
| Katrin Arndt | Visual Effects Producer |
| Angus Bickerton | Visual Effects Supervisor |
| Hugh Macdonald | Visual Effects Supervisor |
| Michael Maroussas | Dialogue Editor |
| Jack Stew | Foley |
| Samir Foco | Sound Effects Editor |
| Alistair Hawkins | Sound Effects Editor |
| Jed Loughran | Sound Effects Editor |
| Brendan Nicholson | Sound Re-Recording Mixer |
| Richard Pryke | Sound Re-Recording Mixer |
| James Mather | Supervising Sound Editor |
| Michelle Cort | Digital Intermediate |
| Laura Daniel | Digital Intermediate |
| Tim Drewett | Digital Intermediate |
| Beren Sowter-Croll | Digital Intermediate |
| Alex Fenn | First Assistant Editor |
| Malcolm Roberts | Construction Coordinator |
| Toby Ford | First Assistant Director |
| James O'Donnell | Stunt Coordinator |
| Rob Mayor | Prosthetic Designer |
| Neill Gorton | Prosthetic Designer |
| Josh Hayes | Storyboard Artist |
| Craig Armstrong | Original Music Composer |
| Max Landis | Story |
| Ira Shuman | Executive Producer |
| Sasha Harris | Production Manager |
| Ira Shuman | Unit Production Manager |
| Davide Losi | Sculptor |
| Marc Mailley | Stunts |
| Colin Nicolson | Production Sound Mixer |
