 | Benicio del Toro als Lawrence Talbot |
 | Anthony Hopkins als Sir John Talbot |
 | Emily Blunt als Gwen Conliffe |
 | Hugo Weaving als Inspector Francis Abberline |
 | Geraldine Chaplin als Maleva |
 | Art Malik als Singh |
 | Antony Sher als Dr. Hoenneger |
 | David Schofield als Constable Nye |
 | Cristina Contes als Solana Talbot |
 | David Sterne als Kirk |
 | Elizabeth Croft als Ophelia |
 | Simon Merrells als Ben Talbot |
 | Asa Butterfield als Young Ben |
 | Olga Fedori als Young Gypsy Woman |
 | Lorraine Hilton als Mrs. Kirk |
 | John Owens als Asylum Doctor #1 |
 | Gemma Whelan als Gwen's Maid |
 | Nicholas Day als Colonel Montford |
 | Clive Russell als MacQueen |
 | Emily Cohen als Little Gypsy Girl |
 | Michael Cronin als Dr. Lloyd |
 | Max von Sydow als Passenger on Train (Director's Cut) (uncredited) |
| Mario Marin-Borquez als Young Lawrence |
| David Self | Screenplay |
| Shelly Johnson | Director of Photography |
| Andrew Kevin Walker | Screenplay |
| Joe Johnston | Director |
| Frank Connor | Still Photographer |
| Stratton Leopold | Co-Producer |
| Milena Canonero | Costume Design |
| Walter Murch | Editor |
| Rick Yorn | Producer |
| Scott Stuber | Producer |
| Dennis Virkler | Editor |
| Sean Daniel | Producer |
| John Dexter | Art Direction |
| Benicio del Toro | Producer |
| Phil Harvey | Art Direction |
| Rick Heinrichs | Production Design |
| Priscilla John | Casting |
| Andy Nicholson | Supervising Art Director |
| John Bush | Set Decoration |
| Sachin Bangera | Visual Effects |
| Ryan Kavanaugh | Executive Producer |
| Bill Abbott | Music Editor |
| Chris Newlin | Music Editor |
| Derek Somaru | Music Editor |
| Katie Harlow | Script Supervisor |
| Jon Title | Sound Effects Editor |
| Barbara McDermott | Music Editor |
| Jay Duerr | Music Editor |
| Lori Berlanga | Production Supervisor |
| Christopher Assells | Sound Effects Editor |
| Alex Gibson | Music Editor |
| Chris Jenkins | Sound Re-Recording Mixer |
| Allison Wyldeck | Costume Supervisor |
| Per Hallberg | Supervising Sound Editor |
| Karen Baker Landers | Supervising Sound Editor |
| Peter Staubli | Sound Effects Editor |
| Bill Carraro | Executive Producer |
| Kathy Nelson | Music Supervisor |
| Danny Elfman | Original Music Composer |
| Scott Stambler | Music Editor |
| Lisa Vick | Script Supervisor |
| Frank A. Montaño | Sound Re-Recording Mixer |
| Peter Staubli | Sound Designer |
| Jon Mone | Executive Producer |
| Shie Rozow | Music Editor |
| Helen Xenopoulos | Assistant Art Director |
| Roderick Barron | Camera Operator |
| Jonathan Earp | Camera Operator |
| Ross Johnson | Visual Effects Coordinator |
| Huseyin Caner | Visual Effects Supervisor |
| Bob Peishel | Digital Intermediate |
| Alyson Dee Moore | Foley |
| Suzie F. Wiesmann | Production Manager |
| Julia Newell | Construction Coordinator |
| Jeetendra G. Bhagtani | Lead Animator |
| Anders Langlands | CG Supervisor |
| Pascal Loef | Visual Effects Technical Director |
| Maralyn Sherman | Hairstylist |
| Gail Rowell-Ryan | Hairstylist |
| Lesley Hamon | Makeup Artist |
| Emma Hutton | Costume Coordinator |
| John Higgins | Gaffer |
| Wayne Leach | Rigging Gaffer |
| Andrew Whitehurst | CG Supervisor |
| Gill Raddings | Animal Coordinator |
| Lisa Westcott | Hair Designer |
| Robert Worley | Assistant Costume Designer |
| Emma Brown | Seamstress |
| Robert Binnall | Camera Operator |
| Alf Tramontin | Steadicam Operator |
| Paul Worley | Dolly Grip |
| Simon Pynn | Matchmove Supervisor |
| Adam Valdez | Visual Effects Supervisor |
| Chris Jargo | ADR Editor |
| Robert Karn | Makeup Artist |
| Tracy Low | Construction Coordinator |
| Thomas R. Cahill | Property Master |
| Pete Cavaciuti | Steadicam Operator |
| Nikos Kalimerakis | Gaffer |
| Jigesh Gajjar | Matchmove Supervisor |
| Darryl Paterson | Property Master |
| Des Whelan | Camera Operator |
| Fraser Taggart | Second Unit Director of Photography |
| John Roesch | Foley |
| Kati Hood | Wigmaker |
| Gabi Brown | Art Department Coordinator |
| Abigail Barbier | ADR Voice Casting |
| Ian Townsend | Techno Crane Operator |
| Matt Logue | Animation Supervisor |
| Tim Miller | Sequence Supervisor |
| Karen M. Murphy | Visual Effects Producer |
| Martin Hobbs | Visual Effects Producer |
| Peter Dorme | Assistant Art Director |
| Natasha Bailey | Seamstress |
| Harvey Harrison | Second Unit Director of Photography |
| Bronwyn Edwards | 2D Supervisor |
| Jennifer Avery | Visual Effects Coordinator |
| Samantha Townend | Visual Effects Coordinator |
| Chris Coupland | Visual Effects Editor |
| Nana Fischer | Hairstylist |
| Paul Gooch | Hairstylist |
| Bojana Nikitović | Assistant Costume Designer |
| Jamie Harcourt | Camera Operator |
| Darren Quinn | Key Grip |
| Gracie Edscer | Visual Effects Coordinator |
| Crystal Hadcroft | Visual Effects Editor |
| Steve Foster | Gaffer |
| John Flemming | Key Grip |
| Pauline Duvall | Sequence Supervisor |
| Péter Závorszky | Visual Effects Producer |
| Fay McConkey | Visual Effects Producer |
| Stuart McCutcheon | Boom Operator |
| Uxue Laguardia | Makeup Artist |
| Arturo Balseiro | Prosthetic Makeup Artist |
| Tim Browning | Assistant Art Director |
| John Bohan | Construction Coordinator |
| Ty Teiger | Property Master |
| David Worley | Camera Operator |
| Patric Roos | CG Supervisor |
| Toby Langley | Visual Effects Coordinator |
| Simon Allmark | Visual Effects Editor |
| Gary Brozenich | Visual Effects Supervisor |
| Paul Corbould | Special Effects Supervisor |
| Dan Osborne | Armorer |
| James Weston | Armorer |
| Everette Webber | Digital Intermediate |
| Josh Weston | Prosthetic Makeup Artist |
| Stephanie Hovette | Wigmaker |
| Louis Elman | ADR Voice Casting |
| Pascal Chappuis | Sequence Supervisor |
| Zeke Morales | Visual Effects Editor |
| Pamela Goldammer | Prosthetic Makeup Artist |
| Barrie Gower | Prosthetic Makeup Artist |
| Göran Lundström | Prosthetic Makeup Artist |
| Shari Ratliff | Art Department Coordinator |
| Brian R. Wells | Animation Supervisor |
| Joe Carhart | Visual Effects Coordinator |
| Steven Begg | Visual Effects Supervisor |
| Matthew Denton | Animatronics Designer |
| Denise Yarde | Boom Operator |
| Gary Hymns | Key Grip |
| John Paul Docherty | Digital Effects Supervisor |
| Andrea Pirisi | Visual Effects Editor |
| Charlotte Keating | Script Coordinator |
| Greg Thompson | First Assistant Editor |
| Joe Dorn | ADR Supervisor |
| Helen Barrett | Makeup Artist |
| Sarah Grispo | Makeup Artist |
| Colleen Kelsall | Assistant Costume Designer |
| Greg Fisher | Animation Supervisor |
| Martin Lake | Visual Effects Editor |
| Mark Michaels | Visual Effects Supervisor |
| Scott M. Davids | Visual Effects Supervisor |
| Damian Mitchell | Armorer |
| Gary Dodkin | Boom Operator |
| Frederick H. Stahly | Dialogue Editor |
| Siobhan Lyons | Production Manager |
| Richard Selway | Assistant Art Director |
| Caroline Fallon | Costume Coordinator |
| Marc Woodcock | Lighting Technician |
| Callum Andrew | Techno Crane Operator |
| Jason Bayever | Digital Effects Supervisor |
| Matthew Schmidt | Visual Effects Editor |
| Bill Tlusty | Visual Effects Producer |
| Asregadoo Arundi | Visual Effects Supervisor |
| Dave Elsey | Creature Effects Technical Director |
| Rick Baker | Makeup Effects Designer |
| John Simpson | Greensman |
| Mark Goldblatt | Editor |
| Rick Baker | Special Effects Makeup Artist |
| Curt Siodmak | Original Film Writer |
| Nadia Stacey | Other |
| Nellie Burroughes | Stunts |
| Jo McLaren | Stunts |
| Sian Milne | Stunts |
| Marc Mailley | Stunts |
| Ken Petrie | Special Effects |
