 | Nicolas Cage als Sailor Ripley |
 | Laura Dern als Lula Fortune |
 | Willem Dafoe als Bobby Peru |
 | J.E. Freeman als Marcelles Santos |
 | Crispin Glover als Dell |
 | Diane Ladd als Marietta Fortune |
 | Calvin Lockhart als Reggie |
 | Isabella Rossellini als Perdita Durango |
 | Harry Dean Stanton als Johnnie Farragut |
 | Grace Zabriskie als Juana Durango |
 | Sherilyn Fenn als Girl in Accident |
 | Glenn Walker Harris Jr. als Pace Fortune |
 | Marvin Kaplan als Uncle Pooch |
 | William Morgan Sheppard als Mr. Reindeer |
 | David Patrick Kelly als Dropshadow |
 | Freddie Jones als George Kovich |
 | John Lurie als Sparky |
 | Jack Nance als 00 Spool |
 | Pruitt Taylor Vince als Buddy |
 | Gregg Dandridge als Bob Ray Lemon |
 | Frances Bay als Madam |
 | Sheryl Lee als The Good Witch |
 | Charlie Spradling als Irma |
| Blair Bruce Bever als Hotel Custodian |
| Sally Boyle als Aunt Rootie |
 | Peter Bromilow als Hotel Manager |
| Lisa Ann Cabasa als Reindeer Dancer |
 | Frank A. Caruso als Old Bum |
 | Frank Collison als Timmy Thompson |
| Eddy Dixon als Rex |
 | Brent David Fraser als Idiot Punk |
| Cage S. Johnson als Man at Shell Station |
| Valli Leigh als Mr. Reindeer's Resident Valet #2 |
 | Nicholas Love als Man in Wheelchair |
 | Daniel Quinn als Young Cowboy |
| Mia M. Ruiz als Mr. Reindeer's Resident Valet #1 |
 | Billy Swan als Billy Swan |
 | Koko Taylor als Singer at Zanzibar |
 | Ed Wright als Desk Clerk |
 | Darrell Zwerling als Singer's Manager |
 | Debra Lamb als Fire Eater at Party (uncredited) |
| Sigurjón Sighvatsson | Producer |
| Steve Golin | Producer |
| Monty Montgomery | Producer |
| David Lynch | Screenplay |
| Frederick Elmes | Director of Photography |
| David Lynch | Director |
| Johanna Ray | Casting |
| Duwayne Dunham | Editor |
| Mira Tweti | Unit Publicist |
| Richard Hymns | Supervising Sound Editor |
| Randy Thom | Sound Designer |
| Michael Kuhn | Executive Producer |
| Amy Stofsky | Costume Design |
| Patricia Norris | Production Design |
| Jeff Smolek | Stunt Coordinator |
| Mary Sweeney | Script Supervisor |
| Kool Marder | Production Manager |
| Dan Brizendine | Transportation Captain |
| John Yarbrough | Transportation Coordinator |
| Neil Summers | Stunts |
| Orwin C. Harvey | Stunts |
| Steve Kelso | Stunts |
| Ousaun Elam | Stunts |
| Margaux Mackay | First Assistant Director |
| Charles Myers | First Assistant Director |
| Bob Terhune | Stunts |
| Ralph Garrett | Stunts |
| Eddie Wong | Stunts |
| Michael Adams | Stunts |
| Gregg Dandridge | Stunts |
| Steven Hirsch | Second Assistant Director |
| Wally Rose | Stunts |
| Joseph Michael Roth | Stunts |
| Loren Janes | Stunts |
| Bernie Pock | Stunts |
| Mike Ceballos | Stunts |
| Roydon Clark | Stunts |
| Hannah Kozak | Stunts |
| Donna Evans | Stunts |
| W. Thomas Snyder | Second Assistant Director |
| Cheryl Kurk | Assistant Production Coordinator |
| Deepak Nayar | Second Assistant Director |
| John Carney | Best Boy Electric |
| Jules Labarthe | Electrician |
| Kim Kono | Electrician |
| Don Power | Special Effects |
| Fríða Aradóttir | Hairstylist |
| Irv Katz | Best Boy Grip |
| Marion C. Weimer-Mirley | Scenic Artist |
| Frank Silva | Property Master |
| David Dubois | Rigging Gaffer |
| Malcolm Doran II | Grip |
| Kenneth Berg | Construction Foreman |
| J.K. Nageldinger | Carpenter |
| Deborah Winship | Assistant Set Decoration |
| Michelle Bühler | Makeup Artist |
| Katherine M. Butler | Second Assistant Camera |
| John Wentworth | Sound Effects Designer |
| George A. Hock | Grip |
| Cobie Fair | Grip |
| David A. Carpender | Assistant Property Master |
| Paul Hauser | Electrician |
| Louis Lazzara | Special Effects Makeup Artist |
| Randy Ratliff | Grip |
| Nancy Martinelli | Art Department Coordinator |
| Charles Armstrong | Construction Coordinator |
| Renton-Paul Medcalf | Grip |
| Corwin A. Bibb | Grip |
| James Intveld | Vocal Coach |
| Rob Scott | Boom Operator |
| Patrick Reddish | Gaffer |
| Rob Sweeney | First Assistant Camera |
| Stuart Abramson | Dolly Grip |
| Curtis Bradford | Grip |
| Ken Wheeland | Grip |
| Gretchen Armstrong | Scenic Artist |
| Denise Dellavalle | Makeup & Hair Assistant |
| Marjorie Webster | Production Coordinator |
| Kurek Ashley | Grip |
| Leslie Weimer | Scenic Artist |
| Cheri Reed | Set Costumer |
| Daniel Kuttner | On Set Dresser |
| Dan Kneece | Steadicam Operator |
| Michael Shore | Key Grip |
| Paul Burge | Carpenter |
| Jon Huck | Sound Mixer |
| John Vecchio | Electrician |
| Bruce McCleery | Rigging Gaffer |
| Steve Alessi | Grip |
| Kimberly Wright | Still Photographer |
| David B. Miller | Special Effects Makeup Artist |
| Chris Kiperman | Grip |
| Kimberley Vashiell | Choreographer |
| Eric DaRe | Casting Assistant |
| Mary Sweeney | First Assistant Editor |
| Mike Clark | Driver |
| Jenny Hicks | Assistant Editor |
| Dean Anthony | Extras Casting |
| Carol Autenrieth | Driver |
| Russ Tolliver | Driver |
| Deborah Gavlak | Assistant Editor |
| Steve Mann | Driver |
| Thomas P. Donovan | Driver |
| Brian Berdan | First Assistant Editor |
| Allan Tietjen | Driver |
| Darwin Joston | Driver |
| Kimberly Edwards | Production Accountant |
| Bob Shapiro | Assistant Accountant |
| Allan W. Herendeen | Driver |
| Shawn Solomon | Driver |
| John Verbeck | Dialogue Editor |
| John Nutt | Dialogue Editor |
| Sara Bolder | Dialogue Editor |
| Jenny Oznowicz | Assistant Sound Editor |
| Frank E. Eulner | Assistant Sound Editor |
| Rob Fruchtman | Dialogue Editor |
| Michael Silvers | Dialogue Editor |
| Ken Fischer | Sound Effects Editor |
| Kristen Gerstner | Assistant Sound Editor |
| Luis Colina | Sound Effects Editor |
| Scott Guitteau | Assistant Sound Editor |
| Gwendolyn Yates Whittle | Assistant Sound Editor |
| Donna Jaffe | Assistant Sound Editor |
| J.R. Grubbs | Assistant Sound Editor |
| David Slusser | Music Editor |
| Kim Cascone | Assistant Sound Editor |
| Susan Sanford | Assistant Sound Editor |
| David Parker | Sound Re-Recording Mixer |
| Luis Lara | Catering |
| Vivian Hengsteler | Negative Cutter |
| Adam Morris | Art Department Assistant |
| Richard Murken | Key Production Assistant |
| G. Marq Roswell | Music Supervisor |
| Scott Chandler | Foley Recordist |
| Tom Myers | Sound Recordist |
| Robin Ginsberg | Post Production Accountant |
| Christy Fiero | Production Assistant |
| Randy Thom | Sound Re-Recording Mixer |
| Bruce Loeb | Security |
| Leonardo | Art Department Assistant |
| Maurice Lospinoso | Production Office Assistant |
| Ute Leonhardt | Post Production Coordinator |
| Susan Carney | Producer's Assistant |
| Brian Steward | Production Assistant |
| Roger L.C. Williams | Art Department Assistant |
| Christopher Stone | Art Department Assistant |
| Mara J. Lee | Set Production Assistant |
| Peter Afterman | Music Consultant |
| Danielle Liekefet | Post Production Coordinator |
| Heidrun Reshöft | Producer's Assistant |
| Eric L. Roberts | Craft Service |
| Robert A. Neft | Production Assistant |
| Catherine Rowe | Foley Artist |
| Jon Huck | Music Consultant |
| Jon Juhlin | Production Office Assistant |
| Gary A. Hecker | Foley Artist |
| Alessandro Rossellini | Set Production Assistant |
| Angelo Badalamenti | Original Music Composer |
| Barry Gifford | Novel |
