 | Eminem als Jimmy B. "Rabbit" Smith |
 | Kim Basinger als Stephanie Smith |
 | Mekhi Phifer als David "Future" Porter |
 | Brittany Murphy als Alex |
 | Evan Jones als Cheddar Bob |
 | Omar Benson Miller als Sol George |
 | De'Angelo Wilson als DJ IZ |
 | Eugene Byrd als Wink |
 | Taryn Manning als Janeane |
 | Larry Hudson als Bouncer |
 | Proof als Lil'Tic |
| Mike Bell als Shorty Mike |
| DJ Head als Battle DJ |
 | Michael Shannon als Greg Buehl |
 | Chloe Greenfield als Lily |
| Mary Hannigan als Mrs. Helgeland |
 | Anthony Mackie als Papa Doc |
| Strike als Lyckety-Splyt |
 | Nashawn 'Ox' Breedlove als Lotto |
| Na'Keya Snoddy als Papa Doc's Girl |
 | Malik Barnhardt als Moochie |
| Day Golfin als Day |
| Allen Adams als Omar |
| Hom als First Parking Lot Rapper |
 | Obie Trice als Second Parking Lot Rapper |
| Njeri Earth als Third Parking Lot Rapper |
| Jennifer Kitchen als Willing Girl |
| Kyla Womack als Alex's Friend |
| Melissa Zaglanikzny als Christine |
| Rockey Black als Rocky |
| Craig Chandler als Paul |
 | Paul Bates als Manny |
| Miz-Korona als Female Lunch Truck Rapper |
 | Xzibit als Male Lunch Truck Rapper |
 | Abdul Salaam El Razzac als Joe Lee Patton |
| Steven Monroe als Plant Worker |
| John Smith Jr. als Lobby Security Guard |
| Venicia Foreman als WJLB Receptionist |
| Waverly W. Alford II als Big O |
| Bushman als WJLB Disc Jockey |
| Adam Brook als Roy Darucher |
 | Brandon T. Jackson als Chin Tiki Club Goer (uncredited) |
| Rodrigo Prieto | Director of Photography |
| Curtis Hanson | Director |
| Curtis Hanson | Producer |
| Scott Silver | Writer |
| Eminem | Songs |
| Jay Rabinowitz | Editor |
| Craig Kitson | Editor |
| Brian Grazer | Producer |
| Jimmy Iovine | Producer |
| Mali Finn | Casting |
| Philip Messina | Production Design |
| Patrick Dougherty | Transportation Captain |
| Dane A. Davis | Supervising Sound Editor |
| Steve Bowen | Digital Color Timer |
| Ben Estrada | Digital Colorist |
| Matiki Anoff | Key Makeup Artist |
| Kevin Kavanaugh | Art Direction |
| Kristen Toscano Messina | Set Decoration |
| Jim Whitaker | Executive Producer |
| Mark Bridges | Costume Design |
| Zane Weiner | Unit Production Manager |
| Stuart Parr | Co-Producer |
| Paul Rosenberg | Executive Producer |
| Richard Boris | Head Greensman |
| Joe Milner | Sound Effects Editor |
| Danny Michael | Production Sound Mixer |
| Andrew Schmetterling | Boom Operator |
| Rick Canelli | ADR Recordist |
| Richard Conkling | First Assistant Editor |
| Nancy Haecker | Assistant Location Manager |
| Gregory Goodman | Executive Producer |
| Paul Richards | Leadman |
| Eric Heffron | First Assistant Director |
| Jeff Imada | Stunt Coordinator |
| Ronnie Specter | Makeup Artist |
| Nickolas Gilbert | Set Dresser |
| Eli Reed | Still Photographer |
| Christopher Eakins | Sound Effects |
| Christian Zimmermann | Standby Painter |
| Bill Summers | Grip |
| Harry E. Otto | Set Designer |
| Jay Levy | First Assistant Camera |
| Donald Mowat | Makeup Supervisor |
| John Casey | Costume Supervisor |
| Chris Snyder | Construction Coordinator |
| Mark Robert Taylor | Art Department Assistant |
| Steven Melton | Property Master |
| Clayton J. Barber | Stunt Double |
| Eva Z. Cabrera | Script Supervisor |
| Stanton Barrett | Stunts |
| Robby Baumgartner | Chief Lighting Technician |
| Alyson Dee Moore | Foley Artist |
| Carlton Kaller | Music Editor |
| Mark Larry | Sound Effects Editor |
| Karen Golden | Additional Script Supervisor |
| David Rumble | Location Assistant |
| Stephanie Flack | Supervising Dialogue Editor |
| Amy Tompkins | Digital Intermediate Editor |
| Gary Jay | Camera Operator |
| Marc Scott | Transportation Coordinator |
| Carolyn Tapp | Foley Recordist |
| Camille Friend | Key Hair Stylist |
| William Eichler | Additional Second Assistant Camera |
| Mark Karavite | Steadicam Operator |
| Stephanie Brown | Assistant Sound Editor |
| Kokayi Ampah | Location Manager |
| Carol McConnaughey | Unit Publicist |
| Kenny Becker | Color Timer |
| Cynthia Blaise | Dialect Coach |
| Chris Crowell | Digital Compositor |
| Mary Jo Lang | Foley Mixer |
| Thom Brennan | Foley Editor |
| Carole Cowley | Digital Intermediate Producer |
| Mark Smith | Sound Re-Recording Mixer |
| Nancy Barker | First Assistant Sound Editor |
| Nicole Sylvester | Art Department Coordinator |
| Gerard Forrest | Construction Foreman |
| Mike Bomar | Set Painter |
| Kathleen Callahan | Craft Service |
| Linda Barnes | Driver |
| John Bullard | Propmaker |
| Darien N. D'Alfonso | Scenic Artist |
| Hilton Napoleon | Security |
| Eric Bretter | Sound Recordist |
| John D. Milinac | Special Effects Coordinator |
| Mary Courtney | Unit Production Manager |
| Tom Rondot | Electrician |
| Michael W. Anderson | Lighting Technician |
| Anthony 'Spike' Simms | Rigging Gaffer |
| Mindy Bazar | Casting Associate |
| Tali Lipa | Production Accountant |
| Marc Gabbana | Storyboard Artist |
| Marvin Williams | Key Set Production Assistant |
| George A. Parker | Technical Supervisor |
| Ralph Bertelle | Production Office Coordinator |
| Deedra Ricketts | Extras Casting |
| John Moore | Construction Buyer |
| Aaron C. Holden Jr. | Assistant Property Master |
| Brad Fanfalone | Camera Loader |
| Donald Glenn | Dolly Grip |
| Christine Orth | Key Costumer |
| Gary Burritt | Negative Cutter |
| Pamela Hilse | Assistant Production Coordinator |
| Stacy Opalewski | Casting Assistant |
| Victoria Rose | Dialogue Editor |
| Gail Carroll-Coe | Utility Sound |
| Michael J. Moore | Second Assistant Director |
| Lizzie Cook | Costumer |
| J.P. "Brendan" Bernardo | Assistant Editor |
| Peter Walts | Assistant Chief Lighting Technician |
| Robert C. Bonnell | Production Assistant |
| Michael Kay | Special Effects Technician |
| Winnye Knight | Assistant Makeup Artist |
| David K. Riebel | Second Second Assistant Director |
| Kevin Dalton | Concept Artist |
| Jim Baker | Special Effects Assistant |
| Dean M. King | First Company Grip |
| Dave De Brincat | Second Assistant Camera |
| Ron Glenn | Second Company Grip |
| Marianna Harrison | Wardrobe Assistant |
| Steven King | Music Arranger |
| Nancy Tarr-Wager | Music Coordinator |
| Taryn Shick | Extras Casting Assistant |
| Jody Beaudin | First Assistant Accountant |
| Marc Labelle | Logistics Coordinator |
| Liz Probst | Payroll Accountant |
| Jamie Biehl | Production Secretary |
| Jeff Bass | Music |
| Luis Resto | Music |
