 | Michael J. Fox als Milo James Thatch (voice) |
 | Cree Summer als Princess 'Kida' Kidagakash (voice) |
 | James Garner als Commander Lyle Tiberius Rourke (voice) |
 | Claudia Christian als Helga Katrina Sinclair (voice) |
 | Phil Morris als Dr. Joshua Strongbear Sweet (voice) |
 | Leonard Nimoy als King Kashekim Nedakh (voice) |
 | John Mahoney als Preston B. Whitmore (voice) |
 | Corey Burton als Gaetan 'The Mole' Moliere (voice) |
 | Don Novello als Vincenzo 'Vinny' Santorini (voice) |
 | Jacqueline Obradors als Audrey Rocio Ramirez (voice) |
 | Florence Stanley als Wilhelmina Bertha Packard (voice) |
 | David Ogden Stiers als Fenton Q. Harcourt (voice) |
 | Natalie Strom als Young Kida (voice) |
 | Jim Varney als Jebidiah Allardyce 'Cookie' Farnsworth (voice) |
 | Jim Cummings als Additional Voices (voice) |
 | Patrick Pinney als Additional Voices (voice) |
| David Reynolds | Other |
| James Newton Howard | Original Music Composer |
| Gary Rydstrom | Sound Designer |
| Gary Rydstrom | Sound Re-Recording Mixer |
| Tom Johnson | Sound Re-Recording Mixer |
| Ruth Lambert | Casting |
| Mary Hidalgo | Casting |
| Michael Silvers | ADR Editor |
| Shannon Mills | Sound Designer |
| Dennie Thorpe | Foley Artist |
| Tony Eckert | Foley Mixer |
| Juan Peralta | Sound Mix Technician |
| Don Hahn | Producer |
| Joss Whedon | Story |
| Jim Varney | In Memory Of |
| Jim Weidman | Supervising Music Editor |
| Mike Mignola | Production Design |
| Rob Nokes | Sound Effects Designer |
| Matthew Jon Beck | Casting Associate |
| Tab Murphy | Screenplay |
| Tab Murphy | Story |
| Gary Trousdale | Director |
| Gary Trousdale | Story |
| Kirk Wise | Director |
| Kirk Wise | Story |
| Ellen Keneshea | Editor |
| Sue Bea Montgomery | Post-Production Manager |
| John K. Carr | Supervising Sound Editor |
| John K. Carr | Associate Editor |
| Dean DeBlois | Story Artist |
| Susan Hegarty | Dialect Coach |
| Matt Codd | Production Design |
| Bryce Zabel | Story |
| Jackie Zabel | Story |
| John Brian King | Title Designer |
| Jeff Atmajian | Orchestrator |
| Lori Korngiebel | Post Production Supervisor |
| Ricardo F. Delgado | Production Design |
| David Olson | Music Editor |
| Kiran Bhakta Joshi | CGI Supervisor |
| Marlon West | Visual Effects Supervisor |
| Kendra Haaland | Associate Producer |
| Cos Aelenei | Still Photographer |
| Ken Fischer | Sound Effects Editor |
| Rick Maki | Visual Development |
| Anthony DeRosa | Supervising Animator |
| Matsune Suzuki | Visual Effects |
| Maria Gonzalez | Color Designer |
| David 'Joey' Mildenberger | Visual Effects |
| Dan Lund | Visual Effects |
| Thomas Baker | Visual Effects |
| Lam Hoang | Layout |
| Jim Martin | Production Design |
| Katie Hooten | Post Production Coordinator |
| Pete Anthony | Conductor |
| David Goetz | Art Direction |
| Joyce Alexander | Painter |
| Kent Melton | Sculptor |
| Al Vasquez | Camera Operator |
| Jonathan Allen | Additional Music |
| Earl Coffman | Compositors |
| Terry Claborn | Color Timer |
| Carol Folgate | First Assistant Editor |
| Andrea McCarthy Paul | Production Accountant |
| Kirsten Bulmer | Production Coordinator |
| Marcie Romano | Assistant Sound Editor |
| Mary Helen Leasman | Foley Editor |
| Boyd Lacosse | Special Effects Supervisor |
| Don Henry | Projection |
| Pei Dieleman | Lighting Artist |
| Plato | Book |
| Frank 'Pepe' Merel | Foley Recordist |
| Rich Mackay | Negative Cutter |
| Lesley Addario Bentivegna | Assistant Production Manager |
| Tom Boyd | Musician |
| Anne Marie Bardwell | Character Designer |
| Virgilio John Aquino | Additional Visual Effects |
| Mary Blee | Assistant Editor |
| Ed Ghertner | Layout Supervisor |
| Vince Caro | Additional Dialogue |
| Kathleen Violet Grey | Administrative Assistant |
| Froydis Boe | Production Assistant |
| Charles 'Chip' Church | Production Secretary |
