 | Dwayne Johnson als Sarge |
 | Karl Urban als John "Reaper" Grimm |
 | Rosamund Pike als Samantha Grimm |
 | Deobia Oparei als Destroyer |
 | Razaaq Adoti als Duke |
 | Al Weaver als The Kid |
 | Ben Daniels als Goat |
 | Richard Brake als Portman |
 | Dexter Fletcher als Pinky |
 | Doug Jones als Dr. Carmack Imp / Sewer Imp |
 | Brian Steele als Hell Knight |
 | Yao Chin als Mac |
 | Robert Russell als Dr. Carmack |
 | Daniel York als Lt. Huengs |
 | Ian Hughes als Sanford Crosby |
 | Sara Houghton als Dr. Jenna Willits |
 | Blanka Jarosova als Dr. Hillary Tallman / Imp |
| Vladislav Dyntera als Dr. Steve Willits |
| Jaroslav Pšenička als Dr. Thurman |
| Marek Motlíček als Dr. Clay |
| Petr Hnětkovský als Dr. Olsen |
| Robert Nelson als Security Guard (uncredited) |
 | Barbara Nedeljakova als Girl at Bar (uncredited) |
 | Tanoai Reed als Dead Scientist Shot (uncredited) |
| Andrzej Bartkowiak | Director |
| Dave Callaham | Screenplay |
| Wesley Strick | Screenplay |
| Lorenzo di Bonaventura | Producer |
| John Wells | Producer |
| John D. Schofield | Executive Producer |
| Clint Mansell | Original Music Composer |
| Tony Pierce-Roberts | Director of Photography |
| Derek Brechin | Editor |
| Stephen Scott | Production Design |
| Dominic Masters | Art Direction |
| Richard Roberts | Set Decoration |
| Carlo Poggioli | Costume Design |
| Rachel Solow | Hairstylist |
| Katka Vávrová | Hairstylist |
| Nuria Mbomio | Hairstylist |
| Pau Loewe | Makeup Artist |
| Jeff Dawn | Makeup Artist |
| Gabriela Dolenská | Art Department Coordinator |
| Charles Leatherland | Assistant Art Director |
| Raymond Perry | Property Master |
| Martina Ter-Akopowá | Construction Coordinator |
| Nick Watson | Dolby Consultant |
| Ian Waggott | Foley |
| Sue Lenny | Dialogue Editor |
| John Leveque | Supervising Sound Editor |
| Michael Fentum | Supervising Sound Editor |
| Simon Chase | Sound Effects Editor |
| Oliver Tarney | Sound Effects Editor |
| Jack Whittaker | Sound Effects Editor |
| Mike Dowson | Sound Re-Recording Mixer |
| Frank A. Montaño | Sound Re-Recording Mixer |
| Kevin Spruce | Animation Supervisor |
| Fredrik Sundqvist | CG Supervisor |
| Jesper Kjölsrud | CG Supervisor |
| Laurent Hugueniot | CG Supervisor |
| Enrique Bilsland | Creature Design |
| Fiona Chilton | Visual Effects Producer |
| Richard Diver | Visual Effects Editor |
| Steve Garrad | Visual Effects Producer |
| Tim Keene | Visual Effects Producer |
| Ray Lau | Visual Effects Editor |
| Gaël Seydoux | Sequence Supervisor |
| Mark Nelmes | Visual Effects Supervisor |
| Jon Farhat | Visual Effects Supervisor |
| Frazer Churchill | Visual Effects Supervisor |
| Pavel Cajzl | Stunt Coordinator |
| Joe Dunne | Stunt Coordinator |
| John Bailie | Camera Operator |
| Jakub Dvorský | Camera Operator |
| Stuart Howell | Camera Operator |
| Jiří Málek | Camera Operator |
| Jaromír Šedina | Steadicam Operator |
| Keith Hamshere | Still Photographer |
| Petr Konrád | Gaffer |
| Václav Čermák | Gaffer |
| Tommy Finch | Gaffer |
| Vladimir Holzknecht | Rigging Gaffer |
| George White | Rigging Gaffer |
| Jo Korer | Costume Supervisor |
| Sarka Zvolenska | Costume Supervisor |
| Viera Zvonarova | Set Costumer |
| Jay Warren | Digital Intermediate |
| Dina Eaton | Music Editor |
| Silvie Janculová | Transportation Coordinator |
| Jiri Kotlas | Transportation Coordinator |
| Sue Field | Script Supervisor |
| Sharon Mansfield | Script Supervisor |
| Pavel Mrkous | Location Manager |
| Geoff Freeman | Unit Publicist |
| Peter Francis | Supervising Art Director |
| Henning Molfenter | Associate Producer |
| Thierry Potok | Associate Producer |
| Laura Holstein | Co-Executive Producer |
| Jeremy Steckler | Co-Executive Producer |
| David Minkowski | Co-Producer |
| Matthew Stillman | Co-Producer |
| Jina Jay | Casting |
| Frantisek Copf | Art Department Assistant |
| Emma Vane | Set Designer |
| František Novák | First Assistant Camera |
| Darren Quinn | Key Grip |
| Roman Kuchar | Grip |
| Giovanni Casalnuovo | Assistant Costume Designer |
| Christine Blundell | Hair Designer |
| Richard Alonzo | Prosthetic Makeup Artist |
| Larisa Šrámková | Seamstress |
| Martin Kotek | Set Dressing Artist |
| Enrique Bilsland | Animatronics Designer |
| Greg Corke | Armorer |
| Pavel Lipert | Carpenter |
| Dion Lam Dik-On | Fight Choreographer |
| Nicola Scott | Dialect Coach |
| Václav Kocman | Driver |
| Andreas Pense | Legal Services |
| Tony Buffa | Makeup Effects |
| Tania Blunden | Post Production Supervisor |
| Jan Meade | Projection |
| Eva Dvorakova | Set Medic |
| Miroslav Mika | Set Production Assistant |
| Ondrej Bylok | Stand In |
| Phil Adams | Stunts |
| Richard Sharkey | Unit Production Manager |
| Viktor Lonek | Video Assist Operator |
| Patrick Clayton | First Assistant Director |
| Petr Sulc | Best Boy Electric |
| Petr Svoboda | Electrician |
| Ben White | Lighting Supervisor |
| Dixie Chassay | Casting Associate |
| Peter Oillataguerre | Executive In Charge Of Production |
| Jim Hajicosta | Production Accountant |
| Sam Holt | Production Coordinator |
| Terry Bamber | Production Manager |
| Tomáš Červenka | Boom Operator |
| Richard Fordham | First Assistant Sound Editor |
| Bruce Fowler | Orchestrator |
| Harry Barnes | Sound Editor |
| Ed Colyer | Sound Mixer |
| John Evans | Special Effects Supervisor |
| Simon Wilkinson | Visual Effects |
| Claudia Dehmel | Visual Effects Coordinator |
| Xavier Roig | Sequence Leads |
| Glen Gathard | Sound |
| Richard J. Landon | Mechanical Designer |
| Shaun O'Dell | Second Unit Director |
| Elliot Scott | Art Department Trainee |
| Jemma Scott-Knox-Gore | Contact Lens Technician |
| Rebecca Higginson | Key Set Costumer |
| Michael Stevenson | Second Assistant Director |
| Aron Clayton | Third Assistant Director |
| Andrew Booth | Creative Director |
| Peter Dorme | Draughtsman |
| Toby Glover | Graphic Designer |
| Karl Derrick | Special Props |
| Martin Asbury | Storyboard Artist |
| Neil Pinkawa | Title Designer |
| Nick Foley | ADR Mixer |
| Johnathan Rush | ADR Recordist |
| Paul Govey | Additional Sound Re-Recording Mixer |
| Paul Hanks | Foley Artist |
| David Mackie | Second Assistant Sound |
| Nigel Bennett | Sound Mix Technician |
| Howard Halsall | Supervising Dialogue Editor |
| Raquel Guirro | Special Effects Assistant |
| Damian Fisher | Special Effects Technician |
| Peter Bebb | VFX Artist |
| Mark Anthony Newman | Stunt Double |
| Marek Havel | Assistant Camera |
| Pavel Proisl | Best Boy Grip |
| Václav Kareš | Camera Loader |
| Jan Carda | Focus Puller |
| Joe Buxton | Libra Head Technician |
| Dan Balzer | Second Assistant Camera |
| Stephen Enticott | Senior Animator |
| Abigail Barbier | ADR Voice Casting |
| Robin Hudson | Casting Assistant |
| Toby Lloyd | Assistant Editor |
| Brano Danis | Colorist |
| Paul Ensby | Digital Colorist |
| Jason Wheeler | Negative Cutter |
| Aisha Bicknell | Post Production Coordinator |
| Markéta Maková | Assistant Location Manager |
| Karolina Cerna | Assistant Accountant |
| Gabriela Rezacova | Catering |
| Helena Masand | CG Artist |
| Debra Coleman | Digital Compositor |
| Jirí Hrstka | Extras Casting |
| Lori Scowley | First Assistant Accountant |
| Mike Eames | Head of Animation |
| Emily Mann | Intern |
| Neil Miller | Matte Painter |
| Alexander Gurlich | Production Assistant |
| Veronika Lencová | Production Secretary |
| Michael Mulholland | Rigging Supervisor |
| Richard Raimbault | Senior Modeller |
| Hana Chýlová | Makeup Artist |
| Tanoai Reed | Stunts |
| Craig Lyn | Technical Supervisor |
