 | Jake Gyllenhaal als Adam Bell / Anthony Claire |
 | Sarah Gadon als Helen Claire |
 | Mélanie Laurent als Mary |
 | Isabella Rossellini als Adam's Mother |
 | Joshua Peace als Carl |
 | Tim Post als Anthony |
 | Kedar Brown als Security Guard |
 | Darryl Dinn als Video Store Clerk |
 | Megan Mane als Lady in the Dark Room |
 | Misha Highstead als Lady in the Dark Room |
 | Alexis Uiga als Lady in the Dark Room |
 | Kiran Friesen als Sad, Broken Woman (uncredited) |
 | Loretta Yu als Receptionist (uncredited) |
 | Stephen R. Hart als Bouncer (uncredited) |
| Paul Stephen als Dark Room Patron (uncredited) |
| Renée April | Costume Design |
| Sean Breaugh | Art Direction |
| Jim Lambie | Set Decoration |
| Denis Villeneuve | Director |
| José Saramago | Novel |
| Matthew Hannam | Editor |
| Javier Gullón | Writer |
| Saunder Jurriaans | Original Music Composer |
| Nicolas Bolduc | Director of Photography |
| Niv Fichman | Producer |
| Danny Bensi | Original Music Composer |
| Miguel A. Faura | Producer |
| Albert Ribas | Sound Editor |
| Marc Bech | Sound Re-Recording Mixer |
| Marc Orts | Sound Re-Recording Mixer |
| Herwig Gayer | Production Sound Mixer |
| Marc Bech | Sound Editor |
| Oriol Tarragó | Sound Designer |
| Oriol Tarragó | Supervising Sound Editor |
| Sam Hudecki | Storyboard Artist |
| Patrice Vermette | Production Design |
| François Ivernel | Executive Producer |
| Victor Loewy | Executive Producer |
| Cameron McCracken | Executive Producer |
| Mark Slone | Executive Producer |
| Jordan Kerner | Set Dresser |
| Martha Sparrow | Set Designer |
| Alison Reid | Stunt Coordinator |
| Jennifer Vey | Stunt Double |
| John MacLean | Key Grip |
| Deirdre Bowen | Casting |
| Caroline Aquin | Prosthetic Makeup Artist |
| Debra Johnson | Key Hair Stylist |
| Adrien Morot | Prosthetic Designer |
| Morag Ross | Makeup Designer |
| Mark Unterberger | Prosthetic Makeup Artist |
| Reid A. Dunlop | First Assistant Director |
| Patrick Arias | Second Assistant Director |
| Manuel Carrión | Foley Artist |
| Christopher Richards | Casting Associate |
| Terry Banting | Gaffer |
| Chris Paré | Digital Imaging Technician |
| Sean Sealey | Steadicam Operator |
| Daryl Patchett | Stunt Double |
| Daryl Patchett | Stunts |
| Branko Racki | Stunts |
| Mark Ahee | Special Effects Coordinator |
| Frédéric Gagnon | Special Effects Technician |
| Dylan Hankinson | Special Effects Technician |
| Kirk Middleton | Special Effects Technician |
| Marie-Cecile Dahan | Visual Effects Producer |
| Guillaume Champagne | CG Artist |
| Mikaël Damant-Sirois | CG Artist |
| Alan Fregtman | CG Artist |
| Samuel Jacques | CG Artist |
| Raphael Letertre | CG Artist |
| Eric Senecal | CG Artist |
| Irene Smirnova | CG Artist |
