 | William H. Macy als Lefty Maginnis (voice) |
 | Rob Reiner als Screwie (voice) |
 | Brian Dennehy als Babe Ruth (voice) |
 | Ritchie Allen als Officer Bryant (voice) |
 | Jake T. Austin als Yankee Irving (voice) |
 | Cherise Boothe als Rosetta Brewster (voice) |
| Jesse Bronstein als Sandlot Kid #1 (voice) |
| Ralph Coppola als Sandlot Kid #2 (voice) |
 | Whoopi Goldberg als Darlin' (voice) |
| Jason Harris als Announcer (voice) |
 | Ed Helms als Hobo Louie (voice) |
 | Ray Iannicelli als Conductors / Umpire (voice) |
 | Gideon Jacobs als Bully Kid Tubby (voice) |
 | Richard Kind als Hobo Andy / Maitre D' (voice) |
| Marcus Maurice als Willie (voice) |
| Amanda Parsons als Emily Irving (voice) |
 | Mandy Patinkin als Stanley Irving (voice) |
| Will Reeve als Big Kid (voice) |
 | Raven-Symoné als Marti Brewster (voice) |
| Ron Tippe als Hobo Jack (voice) |
 | Joe Torre als Yankees' Manager (voice) |
 | Robert Wagner als Mr. Robinson (voice) |
 | Forest Whitaker als Lonnie Brewster (voice) |
| Conor J. White als Bully Kid Arnold (voice) |
| Rochelle Hogue als Additional Voices (voice) |
 | Sondra James als Additional Voices (voice) |
| Greta Martin als Additional Voices (voice) |
| Christie Moreau als Additional Voices (voice) |
| Sean Oliver als Additional Voices (voice) |
 | Charles Parnell als Additional Voices (voice) |
 | Dennis T. Carnegie als Additional Voices (voice) |
 | Jim Titus als Additional Voices (voice) |
 | Cornell Womack als Additional Voices (voice) |
| Dana Reeve als Emily Irving (voice) |
| Christopher Reeve | Director |
| Colin Brady | Director |
| Dan St. Pierre | Director |
| Howard Jonas | Original Story |
| Robert Kurtz | Screenplay |
| Mike Dharney | Animation |
| Kyran Kelly | Art Department Manager |
| Peter Lee | Art Department Manager |
| Kristen Lester | Art Department Manager |
| Jesse Lickman | Art Department Manager |
| Sam Michlap | Visual Development |
| Tigh Walker | Art Department Manager |
| John Williamson | Animation |
| Rob Bekuhrs | Animation |
| Mary Hidalgo | Casting |
| Ron Tippe | Producer |
| Igor Khait | Producer |
| John Debney | Original Music Composer |
| John Bryant | Editor |
| Richard Chen | Production Design |
| Dan St. Pierre | Production Design |
| Jan Carlee | Director of Photography |
| Andy Wang | Director of Photography |
| John W. Hyde | Executive Producer |
| Morris Berger | Executive Producer |
| Stephen R. Brown | Executive Producer |
| Christopher Reeve | Executive Producer |
| Dana Reeve | Executive Producer |
| Cooper Cowgill | ADR & Dubbing |
| David Scott Smith | Storyboard Artist |
| John Flagg | Storyboard Artist |
| Angelo Libutti | Character Designer |
| Angelo Libutti | Storyboard Artist |
| Brian Mitchell | Storyboard Artist |
| Christian Lignan | Storyboard Artist |
| David Stephan | Storyboard Artist |
| Elizabeth Ito | Storyboard Artist |
| Hank Tucker | Storyboard Artist |
| James Fujii | Storyboard Artist |
| Naeim Khavari | Storyboard Artist |
| Phil Allora | Story Artist |
| Ray daSilva | Storyboard Artist |
| Richard Codor | Storyboard Artist |
| Rui Albene | Storyboard Designer |
| Spyros Tsiounis | Storyboard Artist |
| Willy Hartland | Storyboard Artist |
| Jeff Hand | Screenplay |
