 | Matthew McConaughey als Det. Joe 'Killer Joe' Cooper |
 | Emile Hirsch als Chris Smith |
 | Thomas Haden Church als Ansel Smith |
 | Gina Gershon als Sharla Smith |
 | Juno Temple als Dottie Smith |
 | Marc Macaulay als 'Digger' Soames |
 | Gralen Bryant Banks als Pizza Patron |
 | Carol Sutton als Saleslady |
 | Danny Epper als G-Man |
 | Jeff Galpin als Biker Thug |
 | Scott A. Martin als Pizza Manager |
| Gregory C. Bachaud als Filpatrick |
| Charley Vance als Preacher |
| Julia Adams als Adele (uncredited) |
| Lynette Zumo als Waitress (uncredited) |
| Tracy Letts | Screenplay |
| William Friedkin | Director |
| Denise Chamian | Casting |
| Scott Einbinder | Producer |
| Nicolas Chartier | Producer |
| Peggy A. Schnitzer | Costume Design |
| Tyler Bates | Music |
| Caleb Deschanel | Director of Photography |
| Christopher Woodrow | Executive Producer |
| Ryan Westheimer | Line Producer |
| Laurence Freed | Co-Executive Producer |
| Franco-Giacomo Carbone | Production Design |
| Darrin Navarro | Editor |
| Zev Foreman | Executive Producer |
| Patrick Newall | Unit Production Manager |
| Molly Conners | Executive Producer |
| Alice Baker | Set Decoration |
| Jenn Lee | Production Supervisor |
| Jamin O'Brien | Co-Executive Producer |
| Eli Selden | Associate Producer |
| Patrick Newall | Co-Producer |
| Steve Boeddeker | Sound Designer |
| Giancarlo J. Sini | Production Manager |
| Chuck Picerni Jr. | Stunt Coordinator |
| George Bott | Second Assistant Director |
| Marcos Gonzales | Key Hair Stylist |
| Allison Bauserman | Set Costumer |
| Michael Salven | First Assistant Director |
| Krystal Kershaw | Makeup Department Head |
| Chuck Picerni Jr. | Second Unit Director |
| Kent Richard | Assistant Hairstylist |
| Donna Spahn | Assistant Hairstylist |
| Adrienne Lynn | Assistant Makeup Artist |
| Vicki Cherkas | Executive Producer |
| O.J. Knighten | Animal Wrangler |
| Danny Epper | Stunts |
