 | Tom Hanks als Sam Baldwin |
 | Meg Ryan als Annie Reed |
 | Bill Pullman als Walter |
 | Ross Malinger als Jonah Baldwin |
 | Rosie O'Donnell als Becky |
 | Gaby Hoffmann als Jessica |
 | Rita Wilson als Suzy |
 | Victor Garber als Greg |
 | Rob Reiner als Jay |
 | Tom Riis Farrell als Rob |
 | Carey Lowell als Maggie Baldwin |
 | Barbara Garrick als Victoria |
 | Le Clanché du Rand als Barbara Reed |
 | Kevin O'Morrison als Cliff Reed |
 | David Hyde Pierce als Dennis Reed |
 | Valerie Wright als Betsy Reed |
 | Frances Conroy als Irene Reed |
 | Tom Tammi als Harold Reed |
 | Calvin Trillin als Uncle Milton |
 | Caroline Aaron als Dr. Marcia Fieldstone |
 | Linda Wallem als Loretta |
 | LaTanya Richardson Jackson als Harriet |
 | Tom McGowan als Keith |
 | Steve Mellor als Wyatt |
| Marguerite Schertle als Baltimore Waitress |
 | Dana Ivey als Claire |
 | Brian McConnachie als Bob |
 | Matt Smith als Mailman |
| Amanda Maher als Clarise |
 | Victor Morris als Seattle Maitre D' |
| Philip Mihalski als Seattle Waiter |
 | Donald J. Lee Jr. als Seattle Detective |
| Mary A. Kelly als Nervous Woman on Airplane |
| Diane Sokolow als Tiffany Saleswoman |
 | Hannah Cox als Jessica's Mother |
| Rich Hawkins als Jessica's Father |
| Tamara Plank als Stewardess |
 | Michael Badalucco als New York Taxi Dispatcher |
 | Jeff Mazzola als New York Taxi Dispatcher |
| Philip Levy als Taxi Driver |
 | Julie Janney als Cynthia |
| Tony Zazula als Maitre D' |
| John Boylan als Elevator Man |
| Robert Livingston als Elevator Man |
| Butch Stevenson als Valet |
| Sidney Armus als Information Booth Man |
| Philip Anagnos als Car Driver (uncredited) |
| Jason Bortz als Baltimore Mail Clerk (uncredited) |
| Scott Duthie als Tourist (uncredited) |
| William Rossman als Driver (uncredited) |
 | Nick Taylor als Bartender (uncredited) |
| Clay A. Griffith | Set Decoration |
| Juliet Taylor | Casting |
| Lynda Obst | Executive Producer |
| James W. Skotchdopole | Associate Producer |
| James W. Skotchdopole | First Assistant Director |
| Dan Korintus | Sound Editor |
| Eve Battaglia | Casting Assistant |
| Judy L. Ruskin | Costume Design |
| Jeff Cronenweth | First Assistant Camera |
| Leonard Engelman | Makeup Artist |
| Nora Ephron | Screenplay |
| Nora Ephron | Director |
| Marc Shaiman | Original Music Composer |
| Sven Nykvist | Director of Photography |
| Conrad E. Palmisano | Stunt Coordinator |
| Charlie Daboub | Set Designer |
| David S. Ward | Screenplay |
| Jeff Arch | Screenplay |
| Jeff Arch | Story |
| Gary Foster | Producer |
| Jane Bartelme | Associate Producer |
| Robert M. Reitano | Editor |
| Jeffrey Townsend | Production Design |
| Laura Rosenthal | Casting Associate |
| Patrick Crowley | Executive Producer |
| Patrick Crowley | Unit Production Manager |
| Delia Ephron | Associate Producer |
| Gershon Ginsburg | Art Direction |
| Charley Beal | Art Direction |
| Aleen Keshishian | Casting Assistant |
| Paul A. Levin | Post Production Supervisor |
| Lee Dichter | Sound Re-Recording Mixer |
| Al Cerullo | Pilot |
| Colleen Callaghan | Key Hair Stylist |
| Sharon Ilson | Key Makeup Artist |
| Brick Mason | Storyboard Artist |
| Donald J. Lee Jr. | Second Assistant Director |
| Jeff Mazzola | Property Master |
| Bruce McBroom | Still Photographer |
| Kimberly Adams | Assistant Costume Designer |
| Suzan Wexler | Assistant Art Director |
| Daren Dochterman | Production Illustrator |
| Mitchell E. Dauterive | Production Coordinator |
| James Mazzola | Property Master |
| Richmond L. Aguilar | Chief Lighting Technician |
| Judith M. Brown | Studio Teacher |
| Randy Nolen | Steadicam Operator |
| Heidi Shulman | Key Costumer |
| Richard Friedlander | First Assistant Editor |
| Ira Spiegel | Sound Editor |
| Louis Bertini | Sound Editor |
| Bitty O'Sullivan-Smith | Sound Editor |
| Wendy Skerritt | Art Department Coordinator |
| Michael McCombe | Greensman |
| Sally Roberts | Costumer |
| Dan Edelstein | Assistant Sound Editor |
| Stan Bochner | Sound Editor |
| Eytan Mirsky | Assistant Sound Editor |
| Dow Griffith | Location Manager |
| David Wahnon | Assistant Sound Editor |
| Kevin Jewison | Camera Operator |
| Kirk Francis | Production Sound Mixer |
| Mary A. Kelly | Script Supervisor |
| Michael Kirchberger | Supervising Sound Editor |
| Warren Shaw | Apprentice Sound Editor |
| Robert T. Chestnut | Transportation Captain |
| Nicholas Meyers | Music Editor |
| Bob Kaiser | Color Timer |
| Paul P. Soucek | Assistant Sound Editor |
| Paul Caven | Assistant Chief Lighting Technician |
| Harold Collins | Construction Coordinator |
| Jennifer Campbell | Assistant Production Coordinator |
| Mychal D. Smith | Boom Operator |
| Gene Kearney | Key Grip |
| Tamara Bally | Production Accountant |
| Kay Colvin | Cableman |
| Betsy Sokolow-Sherman | Unit Publicist |
| Donah Bassett | Negative Cutter |
| Bob Riggs | Special Effects Coordinator |
| Harriet Fidlow | ADR Editor |
| Dennis W. Milliken | Transportation Coordinator |
| Barbara Anne Klein | Stunts |
| Judy Pursley | Assistant Accountant |
| Maggie Murphy | Second Second Assistant Director |
| Jeffrey Pollack | Music Consultant |
| Amy Caton-Ford | Extras Casting |
| Joe Hicks | Dolly Grip |
| Jack Bauer | Best Boy Grip |
| Diane L. Langone | Post Production Accountant |
| Marty Oppenheimer | Second Unit Director of Photography |
| Richard Q. King | Assistant Sound Editor |
