 | Jeff Goldblum als Seth Brundle |
 | Geena Davis als Veronica Quaife |
 | John Getz als Stathis Borans |
 | Joy Boushel als Tawny |
 | Leslie Carlson als Dr. Brent Cheevers |
 | George Chuvalo als Marky |
 | Michael Copeman als 2nd Man in Bar |
 | David Cronenberg als Gynecologist |
 | Carol Lazare als Nurse |
| Shawn Hewitt als Clerk |
 | Typhoon als Baboon (uncredited) |
| David Cronenberg | Screenplay |
| David Cronenberg | Director |
| Ronald Sanders | Editor |
| Howard Shore | Original Music Composer |
| James McAteer | Set Designer |
| Mark Irwin | Director of Photography |
| Deirdre Bowen | Casting |
| Carol Spier | Production Design |
| David Evans | Supervising Sound Editor |
| David Coatsworth | Unit Production Manager |
| Denise Cronenberg | Costume Design |
| Jim Weidman | Music Editor |
| Elinor Rose Galbraith | Set Decoration |
| Stuart Cornfeld | Producer |
| Gerry Humphreys | Sound Re-Recording Mixer |
| Kim H. Winther | Second Assistant Director |
| Charles Edward Pogue | Screenplay |
| Chris Walas | Creature Design |
| Lee Wilson | Visual Effects Supervisor |
| Hoyt Yeatman | Visual Effects Supervisor |
| Terry Burke | Foley |
| Richard Cadger | Dialogue Editor |
| Wayne Griffin | Supervising Sound Editor |
| Dwayne McLean | Stunt Coordinator |
| Shonagh Jabour | Makeup Artist |
| Marc Boyman | Co-Producer |
| Jane Tattersall | Sound Effects Editor |
| John Board | First Assistant Director |
| Rolf Harvey | Art Direction |
| Robin O'Donoghue | Sound Re-Recording Mixer |
| Prudence Emery | Unit Publicist |
| Kip Ohman | Co-Producer |
| Ivan Lynch | Hairstylist |
| Nancey Pankiw | Assistant Art Director |
| Marc Corriveau | Property Master |
| Nick Kosonic | Scenic Artist |
| Robin Leigh | ADR & Dubbing |
| Katherine Kean | Animation |
| Mitchell Rothzeid | Animation |
| Scotty Allan | Gaffer |
| Robin Miller | Additional Photography |
| Kenneth Post | Additional Photography |
| Attila Dory | Still Photographer |
| Michael Rea | First Assistant Editor |
| Matthew Wolchock | Transportation Coordinator |
| Gillian Richardson | Script Supervisor |
| Howard Rothschild | Location Manager |
| George Langelaan | Short Story |
| Debbie Cooke | Production Coordinator |
| Homer Denison | Orchestrator |
| Jack Hooper | Negative Cutter |
