 | C. Thomas Howell als Chief Grasso |
 | Judd Nelson als Agent Wilson |
 | Jason London als Cale |
 | Serah D'Laine als Carol Milner |
 | Robert Carradine als Dr. Wexler |
 | Alexander Mendeluk als Ryan |
 | Andrew Amani als Infected Worker #1 |
| Brett Beoubay als Elevator Passenger |
| Darren Arnaud als SWAT Guy |
| Henry Boger als Police Heli Pilot |
| Paul Boger als Infected Worker #2 |
| Robert Bjorklund als Lobby Security Guard |
 | Chuck Bush als Det. Leache |
| Courtney Brin als Susan Verris |
 | Edrick Browne als Tony |
| John Chambers als Williams |
| Serah D'Laine als Carol |
| Seth Duhy als SWAT Guy |
| Ted Ferguson als Old Accountant |
 | Brandon Duracher als Agent Riley |
| Nikki Hester-Jose als Woman on Stairs |
| Raymond Hebert als Business Man |
| Chris Fontana als Infected Worker #3 |
 | Jeff Jonas als Officer Burns |
| Zachariah Jay als Doctor |
| Ira Kortum als Homeless Drunk / Extra |
 | Dominick LaBanca als Security Guard |
| Jerry Leggio als Dr. Andzari |
| Dave Major als SWAT Sniper |
 | Mike Mayhall als Officer Daves |
| Dunbar Merrill als Eric |
| R.D. Miller Jr. als News Anchor |
| Anri Mims als Sheb |
 | Lochlyn Munro als Lohan |
| Johnny Rock als George |
| Lauren Norfleet als Clarissa |
| Lauren Roehm als Day Care Worker |
 | Stan Spry als SWAT Leader |
| Chad Stensgaard als Cop |
| Aaron Phillip Stark als Dispatcher |
 | Darcel White Moreno als Ann |
 | Alicia Leigh Willis als Mandy |
| Arielle Stephens als Allie |
| Patty Yu als June |
 | Teri Wyble als Nurse |
| Ismail Abdur-Rahman als Extra |
| Chandler Adams als Extra |
| Mia Allen als Extra |
| Kale Arndt als Extra |
| Cosette Brown als Extra |
| Ryan Burris als Extra |
| Sam Dietz als Extra |
| Alacias Enger als Extra |
| Naylene Frunk als Extra |
| Christopher J. Greene als Extra |
| Ginger Henington als Extra |
 | Elena Kampouris als Extra |
| Ivy Kampouris als Extra |
| Estin Kigeiz als Extra |
| Josh Kiser als Extra |
| Kyle Lang als Extra |
| Jamie Mallory als Extra |
| Kim Mann als Extra |
| Lee Potter als Extra |
| C. Erica Potter als Extra |
| Cathin Yang als Extra |
| George Mendeluk | Director |
| D. Todd Deeken | Writer |
| Rhett Giles | Co-Producer |
| Henry Boger | Producer |
| George Mendeluk | Executive Producer |
| Stan Spry | Producer |
| Justin Jones | Producer |
| Courtney Brin | Associate Producer |
| D. Todd Deeken | Co-Producer |
| Deven MacNair | Stunts |
| George Killian | Executive Producer |
| Mert Meeker | Executive Producer |
| Courtney Brin | Casting Director |
| Rhett Giles | Casting Director |
| David Major | Stunt Coordinator |
| Nikki Hester-Jose | Stunt Double |
| Jay Torrez | Stunt Double |
| Steve Romminie | Stunt Double |
| Justin Jones | Unit Production Manager |
| Douglas Dean III | First Assistant Director |
| Noreen Perez | Second Assistant Director |
| Brad Reeb | Director of Photography |
| Brad Reeb | Camera Operator |
| Patrick LaValley | First Assistant Camera |
| Peggy Knoebel | Second Assistant Camera |
| Ryan Kunkleman | "B" Camera Operator |
| Jerry Turner | First Assistant "B" Camera |
| Peggy Knoebel | Second Assistant "B" Camera |
| Andrew T. Olsen | Still Photographer |
| Jesse Michael Owen | Steadicam Operator |
| Ryan Kunkleman | Second Unit Director of Photography |
| Rozalyn DeCompte | Art Direction |
| Collin Galyean | Production Designer |
| John Nelson | Second Unit |
| Shawn Nelson | Second Unit |
| John Finley | Set Dresser |
| Eric Breaux | Art Department Assistant |
| Gergory Pickard | Gaffer |
| John Pycha | Key Grip |
| Matt Hoefler | Dolly Grip |
| Darren Arnaud | Grip |
| Michael Dugas | Grip |
| Robby Williams | Best Boy Electric |
| Stanley Wong | Electrician |
| Michael Gilbert | Sound Mixer |
| Ron King | Sound Mixer |
| Lorne Boni | Boom Operator |
| Serah D'Laine | Costume Designer |
| Lauren Norfleet | Assistant Makeup Artist |
| Ira Kortum | Extras Casting |
| Christina Kortum | Key Makeup Artist |
| Jennifer Lemons | Costumer |
| Courtney Brin | Production Coordinator |
| Courtney Brin | Script Supervisor |
| Stuart Sauvarin | Assistant Production Coordinator |
| Zak Klutts | Key Set Production Assistant |
| Veronica Miller | Location Production Assistant |
| Nicolas Mezzanatto | Location Production Assistant |
| Aaron Phillip Stark | Location Production Assistant |
| Michelle Sands | Location Production Assistant |
| Alex Miller | Location Production Assistant |
| Kathleen Turnage | Location Production Assistant |
| Seth Duhy | Location Production Assistant |
| Anthony Fankhauser | Line Producer |
| Todd Giroux | Post Production Supervisor |
| Tara Krick | Post Production Coordinator |
| Andrew Poe | Assistant Editor |
| Tiny Juggernaut | Visual Effects |
| Davey Jones | Visual Effects Producer |
| Tony Kent | Editor |
| Sean Albertson | Editor |
| Kurt Nishimura | First Assistant Editor |
| Noe Chavez | First Assistant Editor |
| Jason Shulman | Visual Effects |
| Ray McFarland | Visual Effects |
| Kurt Nishimura | Visual Effects Editor |
| Kurt Nishimura | Colorist |
| Darren Griffiths | Colorist |
| Ray McFarland | Opening Title Sequence |
| Nathan Matsuda | Additional Visual Effects |
| Kurt Nishimura | Additional Visual Effects |
| Jason Shulman | Additional Visual Effects |
| Duane Stinnett | Additional Visual Effects |
| Zack Howard | Scoring Mixer |
| Russ Gorsline | Dialogue Editor |
| Russ Gorsline | ADR Supervisor |
| Zack Howard | Music Editor |
| Anthony Gainer | Sound Designer |
| Tim Leitch | Sound Effects Editor |
| Noah Davis | Assistant Sound Editor |
| Ryan Collins | Sound Editor |
| Andrew Garrett Lange | ADR Mixer |
| Anthony Gainer | Foley Artist |
| Tim Leitch | Foley Artist |
| Leslie Shatz | Sound Re-Recording Mixer |
| Gabriel Heredia | Sound Re-Recording Mixer |
| Russ Gorsline | Sound Re-Recording Mixer |
